Anthony K.C. Chan
McMaster University
Internal medicineSurgeryIntensive care medicineChemistryPediatricsProspective cohort studyImmunologyLow molecular weight heparinThrombinHeparinAnticoagulantAntithrombinVenous thrombosisThrombosisPopulationIncidence (epidemiology)Clinical trialBiochemistryMedicinePharmacology
427Publications
72H-index
13.1kCitations
Publications 426
Newest
Background: Cerebral Sinus Venous Thrombosis (CSVT) is one of many side effects encountered during acute lymphoblastic leukemia (ALL) therapy. Due to the rarity of cases, lack of data, consensus management, no recommendations exist to target the population at risk. Methods: This is a retrospective chart review of 229 consecutive patients diagnosed with ALL and aged 1–21 years, treated at the Children’s Cancer Institute (CCI) between October 2007 and February 2017. Results: The incidence of CSVT ...
Source
#1Jason Chung (McMaster University)
#2Ivan Stevic (UWO: University of Western Ontario)
Last. Howard H.W. Chan (McMaster University)H-Index: 10
view all 6 authors...
Treatment of venous thromboembolism with concomitant thrombocytopenia is challenging. The platelet threshold for safe administration of anticoagulants is under debate, with minimum platelet count of 50 × 109/l being recommended as the safe cutoff. However, some evidence suggests administration of anticoagulants may still be safe at platelet levels of 30 × 109/l. Therefore, we developed an in-vitro thromboelastography (TEG) study to examine the effect of therapeutic or prophylactic levels of unfr...
Source
#1James Ting (National University of Ireland, Galway)
Last. Mihir D. BhattH-Index: 4
view all 7 authors...
Among children, neonates have the highest incidence of thrombosis due to risk factors such as catheter instrumentation, an evolving coagulation system and congenital heart disease. Low-molecular-weight heparins (LMWHs) are the most commonly used anticoagulants in neonates. Published guidelines delineate dosing and monitoring protocols for LMWH therapy in newborns. However, challenging clinical situations frequently present that warrant healthcare providers to think critically beyond the range of...
Source
#1Rachel Goren (U of T: University of Toronto)
Last. Brian M. Feldman (U of T: University of Toronto)H-Index: 80
view all 17 authors...
OBJECTIVE The primary objective of this study was to assess whether there are different patterns (classes) of joint health in young boys with severe haemophilia A (SHA) prescribed primary tailored prophylaxis. We also assessed whether age at first index joint bleed, blood group, FVIII gene abnormality variant, factor VIII trough level, first-year bleeding rate and adherence to the prescribed prophylaxis regimen significantly predicted joint damage trajectory, and thus class membership. METHODS U...
Source
#1Saunya DoverH-Index: 5
#2Nancy L. Young (Laurentian University)H-Index: 57
Last. Victoria E Price (Dal: Dalhousie University)H-Index: 14
view all 11 authors...
Introduction This study aimed to assess the impact of hemophilia on families, in the context of current and emerging hemostatic therapies, and explore the need for a hemophilia-specific tool targeted at parents of boys aged <4 years. A secondary aim was to develop and validate the new tool. Methods Focus groups were conducted with parents of boys with hemophilia and hemophilia health care providers at Canadian hemophilia treatment centers (HTCs) to review the relevance of the Pediatric Quality o...
Source
#1C. Heleen van Ommen (Boston Children's Hospital)H-Index: 17
#2Manuela Albisetti (Boston Children's Hospital)H-Index: 20
Last. Christoph Male (Medical University of Vienna)H-Index: 32
view all 15 authors...
Pediatric thromboembolism is a rare and heterogenous disease. As a result, there is a paucity of knowledge with regard to natural history, management, and outcomes of most types of pediatric venous and arterial thromboembolism. International research collaboration is needed to fill these knowledge gaps. Not only randomized controlled trials, but also representative observational studies are required to answer all research questions. Therefore, the ISTH SSC Subcommittee on Pediatric and Neonatal ...
1 CitationsSource
#1Theresa N H LeungH-Index: 2
Last. Anthony K.C. Chan (McMaster University)H-Index: 72
view all 3 authors...
Obstructive sleep apnoea syndrome (OSAS) is defined as the intermittent reduction or cessation of airflow due to partial or complete obstruction of the upper airway during sleep. Paediatric OSAS has specific contributing factors, presenting symptoms and management strategies in various age groups. Untreated OSAS can lead to detrimental effects on neurocognitive development and cardiovascular and metabolic functions of a growing child. In the past decade, practice guidelines have been developed t...
1 CitationsSource
#1Victoria E Price (Dal: Dalhousie University)H-Index: 14
#2Saunya DoverH-Index: 5
Last. Nancy L. Young (Laurentian University)H-Index: 57
view all 11 authors...
Introduction The purpose of this study was to review and update the content of the Canadian Hemophilia Outcomes-Kids' Life Assessment Tool version 2.0 (CHO-KLAT), in the context of extended half-life (EHL) factor concentrates (FCs) and to establish the validity and reliability of the updated CHO-KLAT. Methods Focus groups were conducted with boys with hemophilia, their parents, and health care providers across Canada to review the CHO-KLAT v2.0 and determine if any modifications were required. T...
1 CitationsSource
#1Mouri Biswas (McMaster Children's Hospital)
#2Paul M. Ryan (UCC: University College Cork)H-Index: 12
Last. Tapas Mondal (McMaster Children's Hospital)H-Index: 16
view all 6 authors...
AIM To establish the incidence and characteristics of paediatric thrombosis (PT) in a Canadian tertiary care centre during the era of low molecular weight heparin (LMWH). METHODS A retrospective observational case study of all patients <18 years of age evaluated for arterial and venous thrombosis from May 2008 to July 2018 at McMaster Children's Hospital was conducted through the electronic medical record. RESULTS The incidence of PT was 52.2 per 10 000 hospital admissions (n = 477/91 462). Prov...
1 CitationsSource
#1Chantel Cacciotti (McMaster Children's Hospital)H-Index: 3
#2Anthony K.C. ChanH-Index: 72
Last. Mihir D. BhattH-Index: 4
view all 3 authors...
: Treatment options exist for patients with severe hemophilia and high titer factor VIII inhibitors but is often inadequate. Few studies have been conducted to evaluate the utility of short-term corticosteroid therapy for improvement in bleeding complications and temporary or sustained resolution of inhibitors in these patients. We describe 2 patients with acute muscular hematomas successfully treated with 4 to 5 days of oral adjuvant corticosteroid therapy resulting in improvement in their acut...
Source