Ray Naden
McMaster University
PathophysiologyEpidemiologyMultiple-criteria decision analysisInternal medicineEthnic groupEtiologySurgeryPathologyOncologyAnti-nuclear antibodyAutoantibodyDecision analysisPediatricsRadiological weaponMedical physicsRheumatologyCohort studyPathologicalLupus erythematosusRetroperitoneal fibrosisDegos diseaseAntiphospholipid syndromeSystemic lupus erythematosusExacerbationRheumatismRheumatoid arthritisPresentation (obstetrics)AortitisTest (assessment)DiseasePregnancyMEDLINEDelphiDeliriumLupus nephritisIgG4-related diseaseOutcomes researchPopulationPulmonary medicineToxicityInterdisciplinary communicationHigh risk pregnancySignificant differenceTest performancePotential candidateEarly diseaseClinical judgementMulticriteria decisionAcr criteriaHigh likelihoodOutcome measuresReport generationPhase i iiObserver variationChi-square testConfidence intervalClinical trialDelphi methodGenetic predispositionLatent class modelNominal group techniqueMedicineCohortRace (biology)Reduction (complexity)Analysis of variance
12Publications
7H-index
719Citations
Publications 11
Newest
#1Martin Aringer (TUD: Dresden University of Technology)H-Index: 67
#2Ralph Brinks (HHU: University of Düsseldorf)H-Index: 19
Last. Sindhu R. JohnsonH-Index: 33
view all 64 authors...
Background/objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 classification criteria for systemic lupus erythematosus system showed high specificity, while attaining also high sensitivity. We hereby analysed the performance of the individual criteria items and their contribution to the overall performance of the criteria. Methods We combined the EULAR/ACR derivation and validation cohorts for a total of 1197 systemic lupus erythematosus (SLE) a...
1 CitationsSource
#1Medha Barbhaiya (HSS: Hospital for Special Surgery)H-Index: 19
#2Stéphane Zuily (University of Lorraine)H-Index: 19
Last. Doruk Erkan (HSS: Hospital for Special Surgery)H-Index: 54
view all 23 authors...
Objectives An international multi-disciplinary initiative, jointly supported by American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR), is underway to develop new rigorous classification criteria to identify patients with high likelihood of Antiphospholipid Syndrome (APS) for research purposes. We applied an evidence- and consensus- based approach to identify candidate criteria and develop a hierarchical organization of criteria within domains. Methods During Phase...
4 CitationsSource
#1Sindhu R. Johnson (Toronto Western Hospital)H-Index: 33
#2Ralph Brinks (HHU: University of Düsseldorf)H-Index: 19
Last. Martin AringerH-Index: 67
view all 64 authors...
Objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria. Methods Twenty-one SLE centres from 1...
6 CitationsSource
#1Zachary S. Wallace (Harvard University)H-Index: 27
#2Ray NadenH-Index: 7
Last. John H. Stone (Harvard University)H-Index: 94
view all 24 authors...
OBJECTIVE: IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. METHODS: An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators use...
54 CitationsSource
#1Zachary S. Wallace (Harvard University)H-Index: 27
#2Ray Naden (McMaster University)H-Index: 7
Last. John H. Stone (Harvard University)H-Index: 94
view all 20 authors...
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exe...
109 CitationsSource
#1Martin Aringer (TUD: Dresden University of Technology)H-Index: 67
#2Karen H. Costenbader (Brigham and Women's Hospital)H-Index: 70
Last. Sindhu R Johnson (UHN: University Health Network)H-Index: 12
view all 64 authors...
OBJECTIVE: To develop new classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). METHODS: This international initiative had four phases. 1) Evaluation of antinuclear antibody (ANA) as an entry criterion through systematic review and meta-regression of the literature and criteria generation through an international Delphi exercise, an early patient cohort, and a patient surv...
193 CitationsSource
#1Zachary S. WallaceH-Index: 27
#2Yuqing ZhangH-Index: 111
Last. John H. Stone (Harvard University)H-Index: 94
view all 6 authors...
Objective IgG4-related disease (IgG4-RD) is a heterogeneous, multiorgan condition of unclear aetiology that can cause organ failure. Difficulty recognising IgG4-RD contributes to diagnostic delays. We sought to identify key IgG4-RD phenotypes. Methods We used two cross-sectional studies assembled by an international, multispecialty network of IgG4-RD specialists who submitted 765 cases to derive and replicate phenotypic groups. Phenotype groups of disease manifestations and key covariate distrib...
84 CitationsSource
#1Zachary S. Wallace (Harvard University)H-Index: 27
#2Kazuichi Okazaki (Kansai Medical University)H-Index: 83
Last. John H. Stone (Harvard University)H-Index: 94
view all 9 authors...
Background Background: IgG4-related disease (IgG4-RD) is a multi-system immune-mediated condition that can affect nearly any organ. No study has evaluated differences in disease manifestations according to race. We evaluated this in a large cohort of IgG4-RD subjects submitted by an international group of investigators. Objectives Objectives: To evaluate racial differences in manifestations of IgG4-RD. Methods Methods: To validate the ACR/EULAR IgG4-RD Classification Criteria, 76 investigators f...
Source
#1Zachary S. Wallace (Harvard University)H-Index: 27
#2Yuqing Zhang (Harvard University)H-Index: 111
Last. John H. Stone (Harvard University)H-Index: 94
view all 6 authors...
Background IgG4-related disease (IgG4-RD) is a multi-organ immune-mediated condition of uncertain etiology characterised by substantial organ-specific morbidity if not diagnosed and treated promptly. Identifying IgG4-RD subgroups based on the distribution of organ involvement may influence the understanding of pathogenesis and guide clinical management. Objectives To identify phenotypic clusters of IgG4-RD that may differentiate clinically meaningful subgroups using an unbiased method. Methods T...
Source
#1Eli M. Miloslavsky (Harvard University)H-Index: 15
#2Ray Naden (McMaster University)H-Index: 7
Last. John H. Stone (Harvard University)H-Index: 94
view all 20 authors...
Objectives To develop a Glucocorticoid Toxicity Index (GTI) to assess glucocorticoid (GC)-related morbidity and GC-sparing ability of other therapies. Methods Nineteen experts on GC use and outcome measures from 11 subspecialties participated. Ten experts were from the USA; nine from Canada, Europe or Australia. Group consensus methods and multicriteria decision analysis (MCDA) were used. A Composite GTI and Specific List comprise the overall GTI. The Composite GTI reflects toxicity likely to ch...
56 CitationsSource