Yazhou Wang
Jilin University
Internal medicineDownregulation and upregulationEndocrinologyProinflammatory cytokineTumor necrosis factor alphaChemistryIn vitroTLR4Western blotDairy cattleButyrateNF-?BAcidosisLipopolysaccharideI?BaPropionateGastrointestinal tractIntestinal epitheliumMonocarboxylate transporterBlood serump38 mitogen-activated protein kinasesEpitheliumMAPK/ERK pathwayAcute-phase proteinRumenInterleukinProtein kinase APharmacology
4Publications
3H-index
42Citations
Publications 4
Newest
#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Gerd Bobe (Linus Pauling Institute)H-Index: 27
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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Rumen fluid of cows with subacute ruminal acidosis (SARA) has high concentrations of short chain fatty acids (SCFA). However, the mechanism of SCFA accumulation is unknown. The solute-linked carrier 5a8 (SLC5A8) plays a key role in the transportation and absorption of SCFA in the intestinal epithelium. The objective of the current study was to investigate (1) SLC5A8 gene and protein expression in various parts of the bovine gastrointestinal tract, (2) the effect of SCFA on SLC5A8 expression in r...
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#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Yazhou Wang (JLU: Jilin University)H-Index: 3
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 8 authors...
: Subacute ruminal acidosis (SARA) is characterized by the depression of ruminal pH and an increase in the concentrations of short-chain fatty acids (SCFAs) and lipopolysaccharide (LPS) in the rumen of cows. The onset of SARA was linked to the accumulation of SCFAs. However, the mechanism of SCFAs transport is unknown. The proton-linked monocarboxylate transporter (MCT1) plays a vital role in the transportation of SCFAs. The goal of this study was to elucidate the distribution of MCT1 along the ...
6 CitationsSource
#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Yazhou Wang (JLU: Jilin University)H-Index: 3
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 10 authors...
: Subacute ruminal acidosis (SARA) can increase the level of inflammation and induce rumenitis in dairy cows. Berberine (BBR) is the major active component of Rhizoma Coptidis, which is a type of Chinese anti-inflammatory drug for gastrointestinal diseases. The purpose of this study was to investigate the anti-inflammatory effects of BBR on lipopolysaccharide (LPS)-stimulated rumen epithelial cells (REC) and the underlying molecular mechanisms. REC were cultured and stimulated with LPS in the pr...
13 CitationsSource
#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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Background Subacute ruminal acidosis (SARA) is a metabolic disease in high-producing dairy cattle, and is accompanied by rumenitis. However, the mechanism of rumenitis remains unclear. Therefore, the aim of this study was to investigate the molecular mechanism of rumenitis in dairy cows with SARA.
29 CitationsSource