Louise Biquard
Paris Descartes University
PromoterTransgeneGeneLeukemia inhibitory factor receptorDownregulation and upregulationBlood proteinsGene expressionEmbryoLeukemia inhibitory factorOxidative stressPlacentaPreeclampsiaTrophoblastPregnancySyncytiotrophoblastPlacenta DiseasesPlacentationGene isoformAnnexin A1Transcription factor
Publications 3
#1Aurélien Ducat (Paris V: Paris Descartes University)H-Index: 5
#2Betty Couderc (Paris V: Paris Descartes University)H-Index: 2
Last. Daniel Vaiman (Paris V: Paris Descartes University)H-Index: 45
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Summary STOX1 is a transcription factor involved in preeclampsia and Alzheimer disease. We show that the knock-down of the gene induces rather mild effect on gene expression in trophoblast cell lines (BeWo). We identified binding sites of STOX1 shared by the two major isoforms, STOX1A and STOX1B. Profiling gene expression of cells overexpressing either STOX1A or STOX1B, we identified genes downregulated by both isoforms, with a STOX1 binding site in their promoters. Among those, STOX1-induced An...
3 CitationsSource
#1Louise BiquardH-Index: 2
#2Aurélien DucatH-Index: 5
Last. Daniel VaimanH-Index: 45
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Introduction Preeclampsia is a major disease of pregnancy, affecting 2–8% of pregnant women. It is characterized by arterial hypertension and proteinuria occurring from the 20th week of amenorrhea. The STOX1 overexpressing mice develop a preeclamptic syndrome. This model is very relevant to identify potential new actors in preeclampsia because the phenotype is both precocious and severe. Objectives Using this mouse model of severe PE, we aim to identify plasma proteins quantitatively modified du...
#1Rajaa Aouache (French Institute of Health and Medical Research)H-Index: 1
#2Louise BiquardH-Index: 2
Last. Francisco MirallesH-Index: 16
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Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical ...
119 CitationsSource