Rajaa Aouache
French Institute of Health and Medical Research
TransgeneLeukemia inhibitory factor receptorBlood proteinsFetusEmbryoLeukemia inhibitory factorOxidative stressPlacentaPreeclampsiaCytokineDiseasePregnancySyncytiotrophoblastProteinuriaFibrosisPlacenta DiseasesPlacentationGestationMedicineBlood pressure
Publications 3
#1Louise BiquardH-Index: 2
#2Aurélien DucatH-Index: 5
Last. Daniel VaimanH-Index: 45
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Introduction Preeclampsia is a major disease of pregnancy, affecting 2–8% of pregnant women. It is characterized by arterial hypertension and proteinuria occurring from the 20th week of amenorrhea. The STOX1 overexpressing mice develop a preeclamptic syndrome. This model is very relevant to identify potential new actors in preeclampsia because the phenotype is both precocious and severe. Objectives Using this mouse model of severe PE, we aim to identify plasma proteins quantitatively modified du...
#1Daniel Vaiman (French Institute of Health and Medical Research)H-Index: 45
#2Rajaa Aouache (French Institute of Health and Medical Research)H-Index: 1
Last. Francisco Miralles (French Institute of Health and Medical Research)H-Index: 16
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Preeclampsia (PE) is a characterized by de novo hypertension and proteinuria. Women affected with PE have an increased risk of chronic hypertension and premature cardiovascular disease years later. Mice bearing transgenic fetuses overexpressing the human transcription factor STOX1 (storkhead box1) develop a severe preeclamptic phenotype. The molecular analysis of long term cardiovascular risks induced by preeclampsia will be studied using our mouse model. We started with 10 eight to ten-months-o...
#1Rajaa Aouache (French Institute of Health and Medical Research)H-Index: 1
#2Louise BiquardH-Index: 2
Last. Francisco MirallesH-Index: 16
view all 4 authors...
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical ...
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