Y-S Lee
Chungbuk National University
GeneCyclinGuanine nucleotide exchange factorCellRestriction pointMolecular biologyCell fate determinationHippo signaling pathwayHEK 293 cellsSignal transducing adaptor proteinDNA methylationCyclin D1ImmunologyTranscriptional regulationRetinoblastoma proteinOncogeneAdenocarcinomaCell cycleTranscription (biology)EpigeneticsMutationCancer researchEffectorCarcinogenesisCell growthSignal transductionRNARNA polymerase IIIChromatinTranscription factorBiologyCell biologyCancer cellEctopic expression
Publications 4
#1Xin-Zi Chi (CBNU: Chungbuk National University)H-Index: 12
#2J Lee (CBNU: Chungbuk National University)H-Index: 2
Last. Suk-Chul Bae (CBNU: Chungbuk National University)H-Index: 36
view all 6 authors...
Runx3 plays a critical role in restriction-point and defense against cellular transformation
RNA polymerase III (Pol III) transcribes medium-sized non-coding RNAs (collectively termed Pol III genes). Emerging diverse roles of Pol III genes suggest that individual Pol III genes are exquisitely regulated by transcription and epigenetic factors. Here we report global Pol III expression/methylation profiles and molecular mechanisms of Pol III regulation that have not been as extensively studied, using nc886 as a representative Pol III gene. In a human mammary epithelial cell system that rec...
#1J-W Jang (CBNU: Chungbuk National University)H-Index: 1
#2M-K KimH-Index: 3
Last. S-C BaeH-Index: 1
view all 11 authors...
The tumor-suppressor RUNX3 has a critical role in a lineage determination, cell cycle arrest and apoptosis. Lozenge (Lz), a Drosophila homolog of mammalian RUNX family members, has integral roles in these processes and specifically in eye cell fate determination. To elucidate the genetic modifiers of Lz/RUNX3, we performed a large-scale functional screen in a fly mutant library. The screen revealed genetic interactions between the Lz, Rac and Hippo pathways. Analysis of interactions among these ...
#1Y-S Lee (CBNU: Chungbuk National University)H-Index: 4
#2Sang Cheol Bae (CBNU: Chungbuk National University)H-Index: 91
Lung adenocarcinomas, like other cancers, develop through the accumulation of epigenetic and genetic alterations. Numerous studies have shown that K-RAS mutation is among the most important early events in carcinogenesis of the lung. However, it is also well established that growth-stimulating signals feed back into growth-suppressing pathways, and any imbalance in these signaling networks will cause the cell to exit the cell cycle, thereby preventing uncontrolled cell growth. How, then, do K-RA...
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