Aseel Alsouqi
Vanderbilt University Medical Center
Aerobic exerciseActive contour modelAlgorithmFibroblast growth factor 23PrehypertensionInterquartile rangePercentileInternal medicineUrologyInterleukin 21ChemokineEndocrinologyMagnetic resonance imagingOncologyMolecular biologyRenal functionChemistryThresholdingAcquired immune systemAdipokineIn vitroIn vivoEx vivoGeneralized estimating equationNatriuretic peptideT cellSystemic inflammationMultiple myelomaVasopressinSalt (chemistry)AdiponectinInflammationInsulin resistanceBortezomibHemodialysisEtoposideDendritic cellProteasome inhibitorB cellKidney diseaseCalorie restrictionGlucose clamp techniquePeritoneal dialysisInsulinCopeptinThalidomideDialysisCarfilzomibPlasma cell leukemiaOverweightLeptinSalvage therapyEndothelial dysfunctionMonocyteRegimenCD16Interferon-gamma productionAfrican americanSalt contentInsulin sensitivitySalt sensitivityAutomated segmentationModerate to severeSupervised exerciseEffect modificationGold standard (test)Computer sciencePhysiologyIncidence (epidemiology)Confidence intervalPeripheralInterleukin 17Counts per minuteObesitySodiumDiabetes mellitusHormoneMedicineCohortInterleukinBlood pressureImmune systemSegmentationGastroenterologyCell biologyGerminal centerEndurance training
Publications 13
#1Melis Sahinoz (VA: United States Department of Veterans Affairs)H-Index: 1
#1Melis Sahinoz (VUMC: Vanderbilt University Medical Center)
Last. T. Alp Ikizler (Vandy: Vanderbilt University)H-Index: 90
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BACKGROUND Tissue sodium content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) were previously explored using 23Sodium magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of sodium stores in patients on dialysis as well as the factors influencing this sodium accumulation. METHODS In this cross-sectional study, we quantified the calf muscle and skin sodium content in 162 subjects (10 PD, 33 MHD patients, and 119 controls) using 23...
2 CitationsSource
#1Aseel Alsouqi (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Muhammad Ali Khan (MCW: Medical College of Wisconsin)H-Index: 2
Last. Robert F. Cornell (VUMC: Vanderbilt University Medical Center)H-Index: 18
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Abstract Micro-Abstract : This is a retrospective analysis studying KD-PACE as bridging therapy to either transplantation or clinical trial enrollment for patients with relapsed or refractory multiple myeloma. Fifty-two patients received KD-PACE and 31 (60%) were bridged to transplantation or clinical trial. Background : Patients with advanced or aggressive multiple myeloma have limited treatment options to achieve rapid disease control. In eligible patients, VDT-PACE (bortezomib, dexamethasone,...
#1Juan Pablo Arroyo (VUMC: Vanderbilt University Medical Center)H-Index: 16
#2Elvis A. Akwo (VUMC: Vanderbilt University Medical Center)H-Index: 8
Last. T. Alp Ikizler (VUMC: Vanderbilt University Medical Center)H-Index: 90
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Background - Insulin resistance is associated to cardiovascular disease risk and worsened kidney function. Patients with CKD have higher levels of insulin resistance. Elevated levels of copeptin (a surrogate for vasopressin levels), has been associated to increased incidence and progression of CKD as well as incident diabetes mellitus. The purpose of our study was to study the relationship between insulin resistance, copeptin, and CKD. Methods - We performed a cross-sectional study to investigat...
#1Nihal Aydemir (Hittite University)H-Index: 1
Last. Cassianne Robinson-Cohen (VUMC: Vanderbilt University Medical Center)H-Index: 2
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Abstract Background and aims Obesity is a pro-inflammatory risk factor for progression of CKD and cardiovascular disease. We hypothesized that implementation of caloric restriction and endurance exercise would improve adipocytokine profiles in patients with moderate to severe CKD. Methods and Results We enrolled patients with moderate to severe CKD through a multi-center pilot randomized trial of diet and exercise in a 4-arm design (dietary restriction of 10%-15% reduction in caloric intake, exe...
2 CitationsSource
#1Natalia R. Barbaro (VUMC: Vanderbilt University Medical Center)H-Index: 13
#2Justin P Van Beusecum (VUMC: Vanderbilt University Medical Center)H-Index: 7
Last. Annet Kirabo (Vandy: Vanderbilt University)H-Index: 18
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Aims Prior studies have focused on the role of the kidney and vasculature in salt-induced modulation of blood pressure; however, recent data indicate that sodium accumulates in tissues and can activate immune cells. We sought to examine mechanisms by which salt causes activation of human monocytes both in vivo and in vitro. Methods and results To study the effect of salt in human monocytes, monocytes were isolated from volunteers to perform several in vitro experiments. Exposure of human monocyt...
6 CitationsSource
#1Mindy Pike (VUMC: Vanderbilt University Medical Center)H-Index: 4
#2Aseel Alsouqi (VUMC: Vanderbilt University Medical Center)H-Index: 3
Last. Cassianne Robinson-Cohen (VUMC: Vanderbilt University Medical Center)H-Index: 34
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Abstract Introduction Patients are often instructed to engage in multiple weekly sessions of exercise to increase physical activity. We aimed to determine whether assignment to a supervised exercise regimen increases overall weekly activity in individuals with chronic kidney disease (CKD). Methods We performed a secondary analysis of a pilot randomized 2x2 factorial design trial examining the effects of diet and exercise (10-15% reduction in caloric intake, three supervised exercise sessions/wee...
2 CitationsSource
#1Bethany L. Dale (Vandy: Vanderbilt University)H-Index: 7
#2Arvind K. PandeyH-Index: 7
Last. Meena S. MadhurH-Index: 22
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: T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce interleukin 21 (IL21) promote germinal center (GC) B cell responses leading to immunoglobulin (Ig) production. Here we investigate the role of IL21 and Tfh cells in hypertension. In response to angiotensin (Ang) II-induced hypertension, T cell IL21 production is increased, and Il21-/- mice develop blunted hypertension, atte...
8 CitationsSource
#1Elvis A. AkwoH-Index: 8
Last. Adriana M. HungH-Index: 29
view all 6 authors...
#1Elvis A. AkwoH-Index: 8
#2Aseel AlsouqiH-Index: 3
Last. Adriana M. HungH-Index: 29
view all 5 authors...
#1Jasmine M. Greer (Vandy: Vanderbilt University)H-Index: 2
#2Ping Wang (Vandy: Vanderbilt University)H-Index: 10
Last. Baxter P. Rogers (Vandy: Vanderbilt University)H-Index: 31
view all 7 authors...
Objective: To develop and validate an automated segmentation algorithm for the lower leg using a multi-parametric magnetic resonance imaging protocol. Methods: An automated algorithm combining active contour and intensity-based thresholding methods was developed to identify skin and muscle regions from proton Dixon MR images of the lower leg. Tissue sodium concentration was then computed using contemporaneously acquired sodium images with calibrated phantoms in the field of view. Resulting sodiu...