Christina Chui-Wa Poon
Hong Kong Polytechnic University
Akt/PKB signaling pathwayWnt signaling pathwayBone remodelingLRP5ChemistryPHTPPLY294002EstrogenDKK1PhytoestrogensGenisteinIcariinTransfectionMAPK/ERK pathwaySignal transductionProtein kinase BEstrogen receptorPI3K/AKT/mTOR pathwayBiologyCell biology
7Publications
1H-index
11Citations
Publications 6
Newest
#1Nan-Nan Sha (SHU: Shanghai University)H-Index: 4
#2Jia-Li Zhang (SHU: Shanghai University)H-Index: 1
Last. Yan Zhang (SHU: Shanghai University)H-Index: 26
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Osteoporosis, diabetes and hypertension are common concurrent chronic disorders. This study aimed to explore the respective effect of angiotensin II (Ang II) and angiotensin(1-7) [Ang(1-7)], active peptides in the renin-angiotensin system, on osteoblasts and osteoclasts under high glucose, as well as to investigate the osteo-preservative effects of Ang II type 1 receptor (AT1R) blocker and Ang(1-7) in diabetic spontaneously hypertensive rats (SHR). Ang II and Ang(1-7) respectively decreased and ...
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#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Ka-Ying Wong (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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#1Zuo-cheng Qiu (JNU: Jinan University)H-Index: 1
#2Yan Zhang (SHU: Shanghai University)H-Index: 26
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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Abstract 8-prenylgenistein (8PG) was previously reported to exert stronger osteogenic activity than genistein, a well-known soy phytoestrogen. However, the molecular mechanism underlying the actions of 8PG on osteoblasts was far from clear. In the present study, the osteogenic effects and mechanisms of 8PG and genistein were studied using human BMSC and murine pre-osteoblast MC3T3-E1 cells. Our results indicated that the stimulatory effects of 8PG and genistein on osteoblast differentiation were...
2 CitationsSource
#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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Icariin, a flavonoid phytoestrogen derived from Herba epimedii, has been reported to exert estrogenic effects in bone and activate phosphorylation of estrogen receptor (ER) alpha in osteoblastic cells. However, it is unclear whether icariin selectively exerts estrogenic activities in bone without inducing undesirable effects in other estrogen-sensitive tissues. The present study aimed to investigate the tissue-selective estrogenic activities of icariin in estrogen-sensitive tissues in vivo and i...
2 CitationsSource
#1Ming-Xian Ho (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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Genistein and icariin are flavonoid compounds that exhibit estrogen-like properties in inducing bone formation and reducing bone loss associated with estrogen deficiency in both preclinical and clinical studies. However, the mechanisms that are involved in mediating their estrogenic actions in bone cells are far from clear. The present study aimed to study the signaling pathways that mediate the estrogenic actions of genistein and icariin in osteoblastic cells. The effects of genistein and icari...
11 CitationsSource
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