Qingfeng Ruan
Guangzhou University of Chinese Medicine
TriterpenoidPharmacokineticsCircular dichroismHigh-performance liquid chromatographyChemistrySesquiterpeneAspergillus terreusOral administrationIC50FungusAnti-inflammatoryIlex rotundaRAW 264.7 CellsQuantum chemicalPositive controlChromatographyNitric oxideMetabolismStereochemistryPharmacology
14Publications
6H-index
79Citations
Publications 14
Newest
Abstract null null Two undescribed shikimic acid derivatives named shikimerans B and C (1 and 2), one new natural compound shikimeran D (3), as well as five known compounds 4−8 were obtained from the EtOAc extract of the endophytic fungus Chaetomium sp. FZ-4. Their structures were determined by the NMR spectroscopy and HRESIMS examination, while the absolute configurations of compounds 1−3 were clarified based on the electronic circular dichroism (ECD) experiment. These new compounds enriched th...
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#1Shiqin Jiang (Guangzhou University of Chinese Medicine)
#2Xiuting Shen (Guangzhou University of Chinese Medicine)
Last. Jing Jin (SYSU: Sun Yat-sen University)H-Index: 13
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Abstract Background : Croton crassifolius Geisel (CCG, also known as Ji-Gu-Xiang in Traditional Chinese Medicine), is traditionally prescribed for the therapy of rheumatic arthritis and gastrointestinal ulcer. However, the effect of CCG on ulcerative colitis (UC) has not been investigated. Purpose : To explore the therapeutic potential and underlying mechanism of CCG extract against UC by colonic and serum metabolomics. Methods : In order to standardize the CCG extract, UPLC-QTOF-MS was used for...
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#1Qingfeng RuanH-Index: 6
#2Wencong PanH-Index: 1
Last. Zhongxiang ZhaoH-Index: 13
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Abstract Nine previously undescribed butyrolactone and sesquiterpene derivatives, named cyclopentanone A (1), subamolides F and G (2 and 3), secosubamolide F (4), rupestonic acids J − L (5–7), linderaguaianols A and B (8 and 9), together with six known ones 10–15 were isolated from the roots of Lindera glauca. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and Mo2(AcO)4-induced circular dichroism. Comp...
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#1Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yanwen Li (SYSU: Sun Yat-sen University)H-Index: 1
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Abstract Furanasperterpenes A (1) and B (2) with a novel 6/6/6/6/5 pentacyclic skeleton and a new 11-acetoxy-terretonin E (3), were isolated from the marine-derived Aspergillus terreus GZU-31-1. Their structures were elucidated based on spectroscopic methods, and the absolute configurations were determined by X-ray diffraction and electronic circular dichroism (ECD) calculations. A possible biogenetic pathway was proposed. These compounds were evaluated for their lipid-lowering effects in 3T3-L1...
4 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Shenxin Xuan (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
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ETHNOPHARMACOLOGICAL RELEVANCE: Ilicis Rotundae Cortex (IRC), a Chinese crude drug, has been widely utilized in Guangdong and Guangxi provinces of China to treat or prevent cardiovascular diseases. AIM OF STUDY: This investigation aims to study the lipid-lowering effect of IRC, as well as the regulating effect on the endogenous metabolites in hyperlipidemia rats. MATERIALS AND METHODS: High-fat diet induced hyperlipidemia rats were administrated with different doses of IRC extract (0.5, 1.0 and ...
4 CitationsSource
#1Min Zhao (Guangzhou University of Chinese Medicine)H-Index: 4
#2Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Abstract Two new compounds, named penisclerotiorin A (1) and diaporthein C (8), and a new natural product, penidepsidone A (4), together with five known compounds (2, 3, 5–7) were isolated from the fungus Penicillium sclerotiorum GZU-XW03–2. Their structures were assigned using spectroscopic methods, quantum chemical calculations, and single-crystal X-ray diffraction analysis. Penisclerotiorin A (1) that belongs to the highly oxidized diphenyl ether is rare found in natural sources, and it was t...
3 CitationsSource
#1Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yena Liu (SYSU: Sun Yat-sen University)H-Index: 8
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Aspermeroterpene A (1) with an unprecedented and highly congested 5/3/6/6/6/5 hexacyclic skeleton, together with two precursors aspermeroterpenes B (2) and C (3), were isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Their structures were elucidated by quantum chemical calculations, X-ray diffraction, and spectroscopic methods. The biogenetic pathway for 1–3 is proposed. Aspermeroterpenes A–C (1–3) showed significant inhibitory activities against lipopolysaccharide (LPS)-ind...
10 CitationsSource
#1Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
#2Shiqin Jiang (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 9 authors...
Pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5, 7, 7] ring system featuring a α-methylene-γ-lactone moiety, together with new pseudoguaianelactone C (3), were isolated from the roots of Lindera glauca. Pseudoguaianelactones A–C (1–3) inhibited NO production with IC50 values ranging from 1.38 to 4.00 μM. Moreover, all compounds suppressed significantly the production of proinflammatory mediator (TNF-α, IL-6, IL-1β and PGE2) and the enzyme expressi...
2 CitationsSource
#1Yena Liu (SYSU: Sun Yat-sen University)H-Index: 8
#2Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Abstract Four new compounds: diaporthichalasins A-C (1–3) and biatriosporin N (7), along with six known compounds (4–6 and 8–10) were separated from the culture of the fungus Diaporthe sp. GZU-1021. The absolute configurations of 1–3 were determined by quantum chemical calculations, X-ray diffraction, and spectroscopic analysis. The structure of 4 was analyzed by X-ray crystallography analysis for the first time. All of the isolates were evaluated on the production of nitric oxide in lipopolysac...
11 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Hui Li (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 9 authors...
Rotundic acid and pedunculoside are the most abundant constituents in Ilicis Rotundae Cortex, and possess lipid-lowering activity. In this study, we evaluated the pharmacokinetic interactions of rotundic acid with pedunculoside and other ingredients from Ilicis Rotundae Cortex with rotundic acid and pedunculoside, and preliminarily investigated the effects of gut microbiota on their pharmacokinetics using a pseudo-germ-free rat model. After a single oral administration of each monomer, a monomer...
3 CitationsSource