Jing Li
Capital Medical University
GeneInternal medicineSurgeryMetagenomicsOdds ratioCardiologyImmunologyHazard ratioMetabolomicsEssential hypertensionDysbiosisPathogenesisConfidence intervalMyocardial infarctionCancer researchProportional hazards modelGut floraFecesMedicineBiology
49Publications
12H-index
434Citations
Publications 39
Newest
#1Yongsen Ruan (SYSU: Sun Yat-sen University)H-Index: 3
#2Hou M (SYSU: Sun Yat-sen University)
Last. Chen Chen (Capital Medical University)H-Index: 25
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The standard practice of presenting one viral sequence for each infected individual implicitly assumes low within-host genetic diversity. It places the emphasis on the viral evolution between, rather than within, hosts. To determine this diversity, we collect SARS-CoV-2 samples from the same patient multiple times. Our own data in conjunction with previous reports show that two viral samples collected from the same individual are often very different due to the substantial within-host diversity....
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#1Pan Wang (Capital Medical University)H-Index: 5
#2Ying Dong (Capital Medical University)H-Index: 2
Last. Jing Li (Capital Medical University)H-Index: 12
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Smoking not only is one of the most important risk factors of hypertension (HTN), but also alters the composition of gut microbiota (GM) in previous studies. Although dysbiosis of GM has been implicated in HTN, how GM alters in patients with HTN under smoking status is still not clear. This study aimed to explore the difference in intestinal microflora among smokers with HTN (S-HTN), nonsmokers with HTN (NS-HTN), and smokers without HTN (S-CTR) and identify whether cigarette smoking led to disor...
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#1Pan Wang (Capital Medical University)H-Index: 5
#2Ying Dong (Capital Medical University)
Last. Jing Li (Capital Medical University)H-Index: 12
view all 7 authors...
BACKGROUND Hypertension (HTN) is one of the major cardiovascular risk factors, which contributes to increasing target organ damages and cardiovascular morbidity and mortality worldwide. Isolated systolic HTN (ISH) and isolated diastolic HTN (IDH) are two important subtypes of HTN. Previous researches have demonstrated the alteration of fecal bacteria in HTN, but not down to these two sub-types. In order to identify whether the composition of bacterial taxa and functional modules shift in ISH and...
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#1Jing Li (Capital Medical University)H-Index: 12
#2Xinchun Yang (Capital Medical University)H-Index: 18
Last. Jun Cai (Peking Union Medical College)H-Index: 13
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SIGNIFICANCE: Hypertension (HTN) has a complex etiology characterized by genetic and environmental factors. It has become a global health burden leading to cardiovascular diseases and kidney diseases, ultimately progressing to premature death. Accumulating evidence indicated that gut microbiome was associated with metabolic disorders and inflammation, which were closely linked to HTN. Recent Advances: Recent studies using bacterial genomic analysis and fecal microbiota transplantation as well as...
4 CitationsSource
#1Chaowei Hu (Capital Medical University)H-Index: 2
#2Jing Li (Capital Medical University)H-Index: 12
Last. Yongxiang Wei (Capital Medical University)H-Index: 18
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Chronic intermittent hypoxia (CIH) is the primary feature of obstructive sleep apnoea (OSA), a crucial risk factor for cardiovascular diseases. Long non-coding RNAs (lncRNAs) in myocardial infarction (MI) pathogenesis have drawn considerable attention. However, whether CIH participates in the modulation of lncRNA profiles during MI is yet unclear. To investigate the influence of CIH on MI, cardiac damage was assessed by histology and echocardiography, and lncRNA and mRNA integrated microarrays w...
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#1Chaowei Hu (Capital Medical University)H-Index: 2
#2Kun Zuo (Capital Medical University)H-Index: 5
Last. Jing Li (Capital Medical University)H-Index: 12
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Aim Hypertension is a complicated disorder with multifactorial etiology and high heritability. Our previous work has identified L3MBTL4 as a novel susceptibility gene for the development of essential hypertension, accompanied with activation of p38/JNK. Yet, little evidence has been reported whether p38/JNK contributed directly to L3MBTL4-induced vascular remodeling and exploring the potential mechanism of L3MBTL4 in vascular smooth muscle cells (VSMCs). Methods We evaluated the contribution of ...
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#1Jing Li (Capital Medical University)H-Index: 12
#2Kun Zuo (Capital Medical University)H-Index: 5
Last. Xinchun Yang (Capital Medical University)H-Index: 18
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Alternations of gut microbiota (GM) in atrial fibrillation (AF) with elevated diversity, perturbed composition and function have been described previously. The current work aimed to assess the association of GM composition with AF recurrence (RAF) after ablation based on metagenomic sequencing and metabolomic analyses and to construct a GM-based predictive model for RAF. Compared with non-AF controls (50 individuals), GM composition and metabolomic profile were significantly altered between pati...
1 CitationsSource
#1Kun Zuo (Capital Medical University)H-Index: 5
#2Xiaoqing Liu (Capital Medical University)H-Index: 4
Last. Xinchun Yang (Capital Medical University)H-Index: 18
view all 9 authors...
The gut bacteria-derived metabolite trimethylamine-N-oxide (TMAO) has been discussed in various cardiometabolic diseases. However, evidence characterizing the microbial population responsible for TMAO accumulation in patients with atrial fibrillation (AF), an increasingly prevalent arrhythmia, is yet lacking. In order to understand the key gut microorganisms that produce TMAO in AF, trimethylamine (TMA)-synthesis enzymes and metabolic pathways, as well as the potential TMA-producers in gut micro...
1 CitationsSource
#1Xiaoli LiH-Index: 1
#2Jiuchang Zhong (Capital Medical University)H-Index: 4
Last. Xinchun YangH-Index: 18
view all 7 authors...
Background Cardiomyocyte apoptosis plays an important role in the development of heart failure, which leads to high mortality in patients with cardiovascular diseases. In this study, we are focused to identify the role of miRNA-181c in the regulating of myocardial tissue apoptosis in the doxorubicin (DOX) or hypoxia/reoxygenation (H/R) induced H9C2 cardiomyocyte injury. Methods DOX-induced heart failure animal model was established using mice. Total RNA was extracted from tissue and cell using T...
1 CitationsSource
#1Shichao Li (Capital Medical University)H-Index: 3
#2Yuanfeng Gao (Capital Medical University)H-Index: 2
Last. Xinchun Yang (Capital Medical University)H-Index: 18
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OBJECTIVE: Atrial fibrosis plays a critical role in atrial fibrillation (AF). A key event in the pathogenesis of fibrosis is the activation of fibroblasts (FBs) into myofibroblasts (MFBs). Paracrine factors released from MFBs lead to ion channel expression changes in cardiomyocytes (CMs). Downregulation of L-type calcium channel Cav1.2 expression is a hallmark of AF-associated ionic remodeling. However, whether exosome (Exo)-mediated crosstalk between MFBs and CMs regulates Cav1.2 expression rem...
2 CitationsSource