Faidon-Marios Laskaratos
Royal Free Hospital
Survival analysisCancerInternal medicineRadiologySurgeryOncologyMidgutRetrospective cohort studyIntensive care medicineChemistryProspective cohort studyMultidisciplinary approachDouble-balloon enteroscopyLung cancerSomatostatinValue (ethics)GastrostomyCapsule endoscopyAsymptomaticColonoscopyEndoscopyProgressive diseaseNeuroendocrine tumorsDiseaseMalignancyPercutaneous endoscopic gastrostomyTask (project management)FibrosisPercutaneousDesmoplasiaOctreotideRectumStable DiseaseMesenteric fibrosisLanreotide AutogelCarcinoid Heart DiseaseTeaching RoundsAntiproliferative effectIn patientWard roundMultidisciplinary teamCancer researchMedical educationStrokeColorectal cancerDiabetes mellitusGeneral surgeryMedicineCohortBiomarker (medicine)Enterochromaffin cellGastroenterology
36Publications
7H-index
189Citations
Publications 36
Newest
#1Man Liu (SYSU: Sun Yat-sen University)H-Index: 3
#2Faidon-Marios Laskaratos (Royal Free London NHS Foundation Trust)H-Index: 7
Last. Martyn Caplin (Royal Free London NHS Foundation Trust)H-Index: 16
view all 7 authors...
The role of total parenteral nutrition (TPN) in cancer patients is controversial, but it may be a treatment option for some patients with indolent but advanced small intestinal neuroendocrine neopl...
2 CitationsSource
#1Irvin M. Modlin (Yale University)H-Index: 81
#2Mark KiddH-Index: 66
Last. Alexandra KitzH-Index: 2
view all 17 authors...
Introduction Surgery is the only cure for neuroendocrine tumors (NETs), with R0 resection being critical for successful tumor removal. Early detection of residual disease is key for optimal management, but both imaging and current biomarkers are ineffective post-surgery. NETest, a multigene blood biomarker, identifies NETs with >90% accuracy. We hypothesized that surgery would decrease NETest levels and that elevated scores post-surgery would predict recurrence. Methods This was a multicenter ev...
3 CitationsSource
#1Faidon-Marios Laskaratos (Royal Free Hospital)H-Index: 7
#2Joseph Davar (Royal Free Hospital)H-Index: 17
Last. Christos Toumpanakis (Royal Free Hospital)H-Index: 27
view all 3 authors...
PURPOSE OF REVIEW The development of carcinoid heart disease (CHD) is a fibrotic complication of neuroendocrine neoplasms (NEN) which is associated with a poor prognosis. This review aims to summarise the clinical features, investigations and management of this condition. RECENT FINDINGS CHD can affect up to 50% of NET patients with carcinoid syndrome. However, it is often not screened for appropriately and recognised late when patients become symptomatic. A screening strategy with biomarkers an...
Source
INTRODUCTION Above-label doses of somatostatin analogs (SSAs) are increasingly utilized in the management of inoperable/metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs), progressing on standard 4-weekly regimens. OBJECTIVE To evaluate the antiproliferative effect of 3-weekly SSA administration in a retrospective GEP-NETs cohort. METHODS Patients with advanced GEP-NETs, treated with long acting release (LAR) octreotide 30mg or lanreotide Autogel 120mg at a 3-weekly interval, aft...
2 CitationsSource
#1Irvin M. ModlinH-Index: 11
#2Mark KiddH-Index: 4
Last. Faidon-Marios LaskaratosH-Index: 7
view all 17 authors...
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#1Faidon-Marios Laskaratos (Royal Free Hospital)H-Index: 7
#2Man Liu (SYSU: Sun Yat-sen University)H-Index: 3
Last. Christos Toumpanakis (Royal Free Hospital)H-Index: 27
view all 9 authors...
PURPOSE: Surgical resection is the only effective curative strategy for small intestinal neuroendocrine neoplasms (SINENs). Nevertheless, the evaluation of residual disease and prediction of disease recurrence/progression remains a problematic issue. METHODS: We evaluated 13 SINENs that underwent surgical resection of the primary tumour and/or mesenteric mass. Patients were divided in three groups: (a) Group 1: SINENs that underwent resection with curative intent, (b) Group 2: SINENs treated wit...
3 CitationsSource
#1Faidon-Marios Laskaratos (Royal Free London NHS Foundation Trust)H-Index: 7
#2Dalvinder Mandair (Royal Free London NHS Foundation Trust)H-Index: 12
Last. Christos Toumpanakis (Royal Free London NHS Foundation Trust)H-Index: 27
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Purpose Mesenteric fibrosis (MF) in small intestinal neuroendocrine neoplasms (SINENs) is often associated with significant morbidity and mortality. The detection of MF is usually based on radiological criteria, but no previous studies have attempted a prospective, multidimensional assessment of mesenteric desmoplasia to determine the accuracy of radiological measurements. There is also a lack of non-invasive biomarkers for the detection of image-negative MF.
4 CitationsSource
#1Faidon-Marios Laskaratos (Royal Free London NHS Foundation Trust)H-Index: 7
#2Eleni Armeni (Royal Free London NHS Foundation Trust)H-Index: 16
Last. Christos Toumpanakis (Royal Free London NHS Foundation Trust)H-Index: 27
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Purpose The antiproliferative properties of lanreotide autogel (LAN) in gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) were demonstrated in the CLARINET study. However, there is limited literature regarding factors that affect progression-free survival (PFS) in patients with GEP NENs treated with LAN.
2 CitationsSource
#1Apostolos KoffasH-Index: 4
#2Faidon-Marios Laskaratos (Royal Free Hospital)H-Index: 7
Last. Owen EpsteinH-Index: 23
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: Since its introduction to clinical practice nearly 20 years ago, wireless capsule endoscopy has revolutionized the landscape in the diagnosis and management of small bowel diseases. Over the past 10 years, capsule endoscopy has evolved beyond the small intestine and a range of capsules are now available to examine the esophagus, stomach and colon. Because of its ease of use, tolerability, paucity of complications and ability to visualize the entire gastrointestinal tract, capsule endoscopy has...
5 CitationsSource