Yi Cai
Shenyang Pharmaceutical University
PharmacokineticsBlood lipidsMass spectrometryFourier transform ion cyclotron resonanceBioavailabilityChemistryDecoctionMetabolic pathwayRadixIn vivoMetabolomicsItraconazoleFormic acidTriazoleCholesterolPosaconazoleHyperlipidemiaGinsengContext (language use)NiacinTriterpeneBeta-CyclodextrinsChromatographyLipid metabolismAmino acidProtein precipitationPharmacology
Publications 3
#1Yi CaiH-Index: 2
#2Min ZhaoH-Index: 8
Last. Chunjie ZhaoH-Index: 6
view all 6 authors...
: Semen descurainiae oil (SDO) is an important traditional Chinese medicine that was recently discovered to have the function of reducing blood lipids. Metabolomics analyses of plasma, liver and kidney in rats were performed using 1 H-NMR and LC-MS to illuminate the lower blood lipid concentration effect of SDO, and niacin was considered as the active control. The measure of total cholesterol (TC) and low-density-lipoprotein cholesterol (LDL-C) in plasma showed that SDO treatment decreased signi...
1 CitationsSource
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Juan Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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: Posaconazole (PCZ) is a triazole antifungal agent with an extended spectrum of antifungal activity. It is approved for the prophylaxis of invasive fungal infections in patients with neutropenia or in hematopoietic stem cell transplant recipients undergoing high-dose immunosuppressive therapy for graft-vs-host disease, and for the treatment of fungal infections. However, its pharmacological effects are severely limited owing to its poor solubility and low bioavailability. In order to solve thes...
2 CitationsSource
#1Zhibo Guan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Abstract Sijunzi decoction, a renowned Chinese prescription has long been utilized to treat gastrointestinal problems. In the context of this research work, the use of Ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry was made to separate and characterize the components of Sijunzi decoction. The performance of Liquid chromatography was carried out on a C8 column (150 mm × 2.1 mm, 1.8 μm); moreover, the mobile phase were consist...
10 CitationsSource