Young Yun Jung
Kyung Hee University
PhosphorylationCancerChemokineSTAT proteinElectrophoretic mobility shift assayKinaseChemistryApoptosisIn vitroIn vivoSurvivinBortezomibSTAT3Stat3 Signaling PathwayProgrammed cell deathCancer researchViability assayCarcinogenesisCell growthSignal transduction
13Publications
6H-index
138Citations
Publications 14
Newest
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Jeong-Hyeon Ko (Kyung Hee University)H-Index: 13
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 7 authors...
Hypercholesterolemia has been found to be closely linked with a significant increase in both cancer incidence and mortality. However, the exact correlation between serum cholesterol levels and cancer has not been completely deciphered. Here we analyzed the effect of low-density lipoprotein (LDL) cholesterol on prostate and pancreatic cancer cells. We noted that LDL induced a substantial STAT3 activation and JAK1, JAK2, Src activation in diverse prostate and pancreatic tumor cells. Moreover, LDL ...
1 CitationsSource
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Jae-Young Um (Kyung Hee University)H-Index: 30
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 6 authors...
Abstract Background: Leelamine (LEE) is a lipophilic diterpene amine phytochemical, which can be naturally extracted from pine's bark trees. It has been extensively studied recently for its promising chemopreventive and anti-cancer effects against various cancers such as that of prostate and breast. Hypothesis: We examined the potential impact of LEE in affecting the activation of signal transducer and activator of transcription 3 (STAT3) and promoting apoptosis in human multiple myeloma (MM) ce...
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#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2In Jin Ha (Kyung Hee University)H-Index: 1
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 5 authors...
Abstract Introduction The development of cancer generally occurs as a result of various deregulated molecular mechanisms affecting the genes that can control normal cellular growth. Signal transducer and activator of transcription 3 (STAT3) pathway, once aberrantly activated can promote carcinogenesis by regulating the transcription of a number of oncogenic genes. Objectives Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogeni...
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#1Young Yun JungH-Index: 6
#2Jeong-Hyeon KoH-Index: 13
Last. Kwang Seok AhnH-Index: 56
view all 5 authors...
Purpose: The potential effects of bergamotiin (BGM) on the suppression of cancer cachexia was evaluated under in vitro and in vivo conditions to investigate its possible inhibitory effects on the muscle and fat loss. Method: The differentiated C2C12 and 3T3L1 cells were treated with BGM after the induction of cancer-cachexia with pancreatic cancer conditioned media (CM). The expression levels of the various molecules involved in the differentiation and loss of muscle and fat (MuRF-1, Atrogin-1, ...
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#1Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 21
#2Yin Yin Liew (NUS: National University of Singapore)
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 11 authors...
Abstract Breast cancer is a prominent type of malignancy among women with a high rate of mortality. A number of previous studies have demonstrated the anticancer potential of brucein D (BD), a quassinoid extracted from Brucea javanica, against the cancers of the pancreas, bone, and liver. We investigated the impact of BD on apoptotic as well on mitogen-activated protein kinase (MAPK) signaling cascades against breast cancer cells. The effect of BD on p38 MAPK and JNK signaling pathways and its d...
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#2Young Yun Jung (Kyung Hee University)H-Index: 6
Last. Dongwoo NamH-Index: 24
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The in vitro anti-inflammatory and skin moisturizing activities of Pilea martini (Levl.) Hand.-Mazz. were investigated on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and human immortal...
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#1Jong Hyun Lee (Kyung Hee University)H-Index: 21
#2Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 21
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 15 authors...
Abstract Epithelial-mesenchymal transition (EMT) is a process of transdifferentiation where epithelial cells attain mesenchymal phenotype to gain invasive properties and thus, can contribute to metastasis of tumor cells. Here, we investigated the antimetastatic and antitumor efficacy of brusatol (BT) in a hepatocellular carcinoma (HCC) model. BT reduced the growth and invasive potential of HCC cells. We evaluated the action of BT on EMT-related proteins and found that BT restored the expression ...
21 CitationsSource
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Jae-Young Um (Kyung Hee University)H-Index: 30
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 7 authors...
Matrine, a quinolizidine alkaloid, is commonly employed for treating various viral and inflammatory disorders. Here, we have evaluated matrine for its activity on C-X-C chemokine receptor type 4 (CXCR4) and matrix metalloproteinases (MMP-9/2) expression, and its potential to affect tumor metastasis and invasion. The effects of matrine on CXCR4, MMP-9/2, and nuclear factor κB (NF-κB) activation in lung (A549), prostate (DU145), and pancreas (MIA PaCa-2) cells were investigated by diverse techniqu...
2 CitationsSource
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Muthu K. Shanmugam (NUS: National University of Singapore)H-Index: 47
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 8 authors...
Fangchinoline (FCN) derived from Stephaniae tetrandrine S. Moore can be employed to treat fever, inflammation, rheumatism arthralgia, edema, dysuria, athlete’s foot, and swollen wet sores. FCN can exhibit a plethora of anti-neoplastic effects although its precise mode of action still remains to be deciphered. Nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) can closely regulate carcinogenesis and thus we analyzed the possible action of FCN may have on these two signaling cascades in tumo...
16 CitationsSource
#1Myriam Merarchi (University of Paris)H-Index: 3
#2Young Yun Jung (Kyung Hee University)H-Index: 6
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 5 authors...
For the last couple of decades, natural products, either applied singly or in conjunction with other cancer therapies including chemotherapy and radiotherapy, have allowed us to combat different types of human cancers through the inhibition of their initiation and progression. The principal sources of these useful compounds are isolated from plants that were described in traditional medicines for their curative potential. Leelamine, derived from the bark of pine trees, was previously reported as...
3 CitationsSource