Ayman El-Seedy
Alexandria University
GeneMolecular biologyMinigeneAndrologyAlleleHuman genomeCystic fibrosisCystic fibrosis transmembrane conductance regulatorPopulationCftr geneApical membraneExonMutationGeneticsRNA splicingMedicineMissense mutationGene duplicationNucleic acid sequenceBiology
26Publications
5H-index
59Citations
Publications 24
Newest
#1Khaled A. Osman (Alexandria University)H-Index: 9
#2Eslam M. Ezz El-Din (Alexandria University)H-Index: 1
Last. Ayman El-Seedy (Alexandria University)H-Index: 5
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Abstract null null The attenuating effect of 150 mg/kg of N-acetylcysteine (NAC) against the oral administration of 7.88 and 202.07 mg/kg/day for 14 days of either chlropyrifos-ethyl (CPE-E) or chlropyrifos-methyl (CPF-M), respectively, in male rat was investigated using biochemical and genetic markers. Biomarkers such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), paraoxonase (PON), adenosine 5′-triphosphatase (ATP-ase), glutathione-S-transferase (GST), catalase (CAT), glutathio...
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#1Eiman I. Zaki (Alexandria University)H-Index: 2
#2Ahmed R. El-Mahdy (Alexandria University)H-Index: 13
Last. Ayman El-Seedy (Alexandria University)H-Index: 5
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Sulphur dioxide (SO2) is used as a preservative in food to prevent its discolouration, and to inhibit the growth of bacteria. Little data is available concerning its in vivo hazardous impact.The present study is therefore designed to examine the cyto-genotoxic potential and the testicular histological alterations in adult mice, induced by SO2 present in the dried apricot leather used to prepare the oriental drink Qamar Al-Deen. Two different forms of drinks were tested; cold and boiled drinks. A...
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#1Nehal Sallam (Alexandria University)H-Index: 1
#2Mounir Moussa (Alexandria University)H-Index: 4
Last. Ayman El-Seedy (Alexandria University)H-Index: 5
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Plants employ DNA methylation to maintain genomic plasticity that allows rapid adaptation to environmental stresses without alteration nucleotide sequence of DNA. The present investigation was carried out to detect DNA methylation changes induced by drought stress in inbred line W22 by using amplified methylation-polymorphism technique. The maize inbred line W22 encountered extensive DNA methylation variations, including hypo- and hypermethylation as a response to drought stress. Differential me...
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#2Khaled A. OsmanH-Index: 9
Last. Ayman El-SeedyH-Index: 5
view all 4 authors...
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#1K.S. El-Gendy (Alexandria University)H-Index: 11
#2Khaled A. Osman (Alexandria University)H-Index: 9
Last. Ayman El-Seedy (Alexandria University)H-Index: 5
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Abstract This work aimed to study the risk assessment procedures of a combination of single and repeated dose of the widely used pesticide, ethoprophos (Etho) and heavy metal cadmium (Cd), on the hematological, biochemical, reproduction and cytogenetic parameters in male mice. The results revealed that the sub-lethal dose (1/50 LD50) of the tested toxic substances (Etho and/or Cd) reduced the body and organ weights, the most hematological profile and the activity of acetylcholine esterase (AChE)...
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#1Eiman I. Zaki (Alexandria University)H-Index: 2
#2Ayman El-Seedy (Alexandria University)H-Index: 5
Last. Heba S. Ramadan (Alexandria University)H-Index: 5
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The present study aimed to disclose the histological alterations and cyto-genotoxic potential induced by citrate- and chitosan-capped AuNPs on liver of adult Swiss albino mice. Animals were randomly divided into 8 groups. The first two groups were intraperitoneally (i.p) injected with physiological saline once and left for 10 days and every other day for 21 days, respectively, and kept as negative control groups. While the third and fourth groups were injected i.p with a single dose of 2 mg/kg o...
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Seriphidium herba-album (syn. Artemisia herba-alba) is a medicinal, aromatic, greenish-silver herb. It is used widely in folk medicine for treatment of diarrhea, abdominal cramps and in the healing of external wounds. It's also used for the treatment of diabetes mellitus, neurological disorders as epilepsy, Alzheimer’s disease, depression and jaundice. In this study we assessed the protocol for callus induction, maturation of somatic embryogenesis, frequency of germination and conversion into pl...
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#1Raí«d Farhat (University of Poitiers)
#2Ayman El-Seedy (University of Poitiers)H-Index: 5
Last. Véronique Ladeveze (University of Poitiers)H-Index: 12
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Cystic Fibrosis is the most common recessive autosomal rare disease found in Caucasian. It is caused by mutations on the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) that encodes for a protein located on the apical membrane of epithelial cells. c.3909C>G (p.Asn1303Lys) is one of the most common worldwide mutations located in nucleotide binding domain 2. The effect of the p.Asn1303Lys mutation on misprocessing was studied by immunofluorescence and western blotting analysis in p...
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#1Hanaa Shafiek (Alexandria University)H-Index: 6
Last. Yehia Khalil (Alexandria University)H-Index: 2
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Objectives: We aimed to investigate the association between P2X7 receptor 1513 A/C genetic polymorphisms and susceptibility to different clinical forms of active tuberculosis in Egyptian population. Methods: A case-control study enrolled 50 patients newly diagnosed as TB −25 with pulmonary TB diagnosed by positive sputum for acid fast bacilli or positive culture and 25 with extrapulmonary TB diagnosed by pathological/bacteriological/immunological studies according to the disease site− and 25 hea...
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#1Raed Farhat (University of Poitiers)H-Index: 2
#2Ayman El-Seedy (University of Poitiers)H-Index: 5
Last. Véronique Ladeveze (University of Poitiers)H-Index: 12
view all 8 authors...
Abstract Cystic fibrosis is caused by mutations on the Cystic Fibrosis Transmembrane conductance Regulator gene ( CFTR ). Exonic mutations may have variable effect on the CFTR protein and may alter the normal localization of CFTR on the apical membrane of epithelial cells or/and its function as a chloride channel. Identifying the effect of a missense mutation can be a first step in helping the medical counseling and the therapeutic strategies. In this study, the effect of the c.965T > C exon 8 m...
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