Heyuan Wang
Jilin University
Composite numberAdipogenesisInternal medicinePeroxisomeDielectricEndocrinologyInnate immune systemLipolysisLipogenesisElectrospinningTransmission electron microscopyLuminescenceWhite adipose tissueMolecular biologyComposite materialGranule (cell biology)ReceptorIntegrin alpha MAzurophilic granuleChemistryMaterials scienceAutophagyCubic crystal systemScanning electron microscopeOxidative stressSteatosisPINK1Nonalcoholic fatty liver diseaseInflammasomeFerroceneInsulin resistanceParkinFatty liverMitophagySteatohepatitisNEFAPalmitic acidCoatingMitochondrionMembraneChemical engineeringLipotoxicityLipid metabolismFatty acid synthaseReactive oxygen speciesCD18Oxidative phosphorylationCD11aMetabolismCalcinationPhotoluminescenceNanofiberCell biologyProtein kinase APharmacology
Publications 4
#1Xinwei Li (JLU: Jilin University)H-Index: 34
#2Zhen Shi (JLU: Jilin University)H-Index: 10
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 15 authors...
BACKGROUND AND PURPOSE: Identifying safe and effective compounds that target to mitophagy to eliminate impaired mitochondria may be an attractive therapeutic strategy for NAFLD. Here, we investigated the effects of cyanidin-3-O-glucoside (C3G) on NAFLD and the underlying mechanism. EXPERIMENTAL APPROACH: NAFLD was induced by a high-fat diet (HFD) for 16 weeks. C3G was administered during the last 4 weeks. In vivo, recombinant adenoviruses and AAV8 were used for overexpression and knockdown of PT...
#1Xudong Sun (JLU: Jilin University)H-Index: 8
#2Xiaobing Li (JLU: Jilin University)H-Index: 23
Last. Xinwei Li (JLU: Jilin University)H-Index: 34
view all 11 authors...
Aims: Nuclear factor E2-related factor 2 (Nrf2) is a regulator of cellular oxidative stress and is also involved in lipid metabolism in adipocytes. However, it remains unknown whether Nrf2 is the l...
#1Xiliang Du (JLU: Jilin University)H-Index: 15
#2Taiyu Shen (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 34
view all 16 authors...
ABSTRACT The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation of the hepatic metabolism to overcome metabolic stress. Fatty liver is one of the main health disorders after parturition. Therefore, to investigate changes in hepatic lipid metabolic status and mitochondria in dairy cows with mild fatty liver, liver and blood samples were collected from healthy cows (n = 15) and cows with mild fatty liver (n = 15). To determine the effects of palm...
#1Wenwen Gao (JLU: Jilin University)H-Index: 5
#2Xiliang Du (JLU: Jilin University)H-Index: 15
Last. Xinwei Li (JLU: Jilin University)H-Index: 34
view all 9 authors...
: The aim of this study was to investigate the changes in hepatic oxidative phosphorylation (OXPHOS) complexes (COs) in patients and cows with non-alcoholic steatohepatitis (NASH) and to investigate the mechanism that links mitochondrial dysfunction and hepatic insulin resistance induced by non-esterified fatty acids (NEFAs). Patients and cows with NASH displayed high blood NEFAs, TNF-α and IL-6 concentrations, mitochondrial dysfunction and insulin resistance. The protein levels of peroxisome pr...
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