Jonathan D. Lynn
Wayne State University
AnatomyDopaminergicMagnetic resonance imagingNeuroscienceCaliberIn vivoNeurochemicalSpleniumCorpus callosumMyelinCheckerboardStem-cell therapyAxonParkinson's diseaseMiddle ageDorsolateral prefrontal cortexWhite matterPrefrontal cortexFinger tappingFiber densityMyelin water fractionSingle sessionT2 relaxationMathematicsGeometric meanReliability (statistics)MicrodialysisDopamineAudiologyNeuroimagingGlutamate receptorResting state fMRIMedicineBiologySteady state (electronics)Sensory system
Publications 4
#1Jonathan D. Lynn (WSU: Wayne State University)H-Index: 2
#2Chaitali Anand (WSU: Wayne State University)H-Index: 4
Last. Jeffrey A. Stanley (WSU: Wayne State University)H-Index: 35
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The myeloarchitecture of the corpus callosum (CC) is characterized as a mosaic of distinct differences in fiber density of small- and large-diameter axons along the anterior-posterior axis; however, regional and age differences across the lifespan are not fully understood. Using multiecho T2 magnetic resonance imaging combined with multi-T2 fitting, the myelin water fraction (MWF) and geometric-mean of the intra-/extracellular water T2 (geomT2IEW) in 395 individuals (7-85 years; 41% males) were ...
4 CitationsSource
#1Chaitali Anand (WSU: Wayne State University)H-Index: 4
#2Andreas M. Brandmaier (MPG: Max Planck Society)H-Index: 17
Last. Naftali Raz (MPG: Max Planck Society)H-Index: 78
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We investigated test–retest reliability of two MRI-derived indices of white-matter microstructural properties in the human corpus callosum (CC): myelin water fraction (MWF) and geometric mean T2 relaxation time of intra/extracellular water (geomT2IEW), using a 3D gradient and multi spin-echo sequence in 20 healthy adults (aged 24–69 years, 10 men). For each person, we acquired two back-to-back acquisitions in a single session, and the third after a break and repositioning the participant in the ...
2 CitationsSource
#1Parnit K. Bhupal (CMU: Central Michigan University)
#2Kevin A. Anderson (CMU: Central Michigan University)
Last. Michael I. Sandstrom (CMU: Central Michigan University)H-Index: 10
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Abstract Background Putative treatments derived from in vivo stem cell transplant-derived dopamine (DA) in hemiparkinsonian rats have been assessed via DA-agonist-induced rotations involving imbalanced intra-hemispheric striatal DA receptor stimulation. However, such tests obscure the natural responses of grafts to sensory stimuli, and drug-induced plasticity can modify the circuit being tested. Thus, we propose an alternative testing strategy using a novel water tank swimming apparatus. New met...
#1Jonathan D. Lynn (WSU: Wayne State University)H-Index: 2
#2Eric A. Woodcock (Yale University)H-Index: 12
Last. Jeffrey A. Stanley (WSU: Wayne State University)H-Index: 35
view all 5 authors...
Abstract Proton functional magnetic resonance spectroscopy (1H fMRS) is a noninvasive neuroimaging technique capable of detecting dynamic changes in glutamate related to task-related demands at a temporal resolution under 1 min. Several recent 1H fMRS studies demonstrated elevated steady-state levels of glutamate of 2% or greater during different ‘task-active’ conditions, relative to a ‘non-task-active’ control condition. However, the ‘control’ condition from these studies does vary with respect...
9 CitationsSource