Ling Zhang
Sichuan University
CancerTargeted drug deliveryAntigenCD8NanocarriersLiposomeChemistryExtracellular matrixMaterials scienceIntegrinIn vitroMicrovesiclesIn vivoTumor microenvironmentProstateInflammationOvalbuminPaclitaxelMelanomaBlood–brain barrierBlockadeInsulinParkinson's diseaseDrug deliveryDrugAutoimmunityProstate cancerSubstantia nigraTargeted therapyExosomeDoxorubicinToxicityErythrocyte membraneInsulin deliveryIntravenous glucoseCancer researchDopamineDiabetes mellitusMedicineImmune systemCell biologyPharmacologyDistribution (pharmacology)
21Publications
9H-index
288Citations
Publications 24
Newest
#1Lang Deng (Sichuan University)H-Index: 3
#2Hanming Zhang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 8 authors...
Pancreatic carcinoma elevates quickly and thus has a high mortality rate. Therefore, early treatment is essential for treating pancreatic carcinoma. KRAS is the most frequently identified and one of the earliest mutations in pancreatic tumorigenesis. Thus, the KRAS-mutant cell is an ideal target for the treatment of pancreatic carcinoma, especially at the early stage. KRAS mutation increases macropinocytosis in pancreatic cancer cells, enhancing the internalization of exosomes. Because acquiring...
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#1Yu Fu (SWU: Southwest University)
#1Yu Fu (SWU: Southwest University)H-Index: 7
Last. Ling Zhang (Sichuan University)H-Index: 9
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Abstract null null Current clinical agents for autoimmunity disorders treatment often cause substantial adverse effects and safety concerns, owing to non-specific immune modulation. Due to the prominent contribution of effector T cells in pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and preferential location of co-stimulatory receptor-ligand pair OX40-OX40L at the inflamed sites, selectively targeting autoaggressive T cells by blockade OX40-OX40L, might represe...
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#1Shiqi Huang (Sichuan University)H-Index: 4
#2Lang Deng (Sichuan University)H-Index: 3
Last. Ling Zhang (Sichuan University)H-Index: 9
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Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung, leading to sharply reduced patients’ survival rate. Effectively treating these tumors thus could improve late stage melanoma with lung metastasis. In this study, we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu (CR(NMe)EKA) decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel (PTX) to lung melanoma tumor sites (TRAIL-[ND-PTX]C...
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#1Bingjie Zhou (Sichuan University)H-Index: 2
#2Min Li (Sichuan University)
Last. Shiqi Huang (Sichuan University)H-Index: 4
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Breast cancer was the leading cause of newly diagnosed cases of tumors in 2020, ranking as the second highest cause of female death. Chemotherapy remains the conventional treatment of choice for breast tumors in most clinical cases. However, it is often accompanied by a poor prognosis and severe side effects, resulting from an insufficient accumulation of the drug at tumor sites and an unsystematic distribution of the drug across the body. Inspired by the fact that breast tumor cells overexpress...
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#1Honglin Xiang (Sichuan University)
#2Qiang Zhang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Currently, ischemic stroke is the leading cause of disability and death worldwide, and the performance of corresponding drugs is often unsatisfactory owing to the complex pathological processes and the impediment of the blood-brain barrier (BBB). Here, we employed various tertiary amino groups, including different linear, cyclic, and bimolecular drug structures, to modify 3-n-butylphthalide (NBP), a natural product used for ischemic stroke treatment, which has poor bioavailability, to generate a...
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#1Jiading Wang (Sichuan University)H-Index: 1
#2Qingsi Wu (Sichuan University)H-Index: 1
Last. Ling Zhang (Sichuan University)H-Index: 9
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The dense extracellular matrix (ECM) in tumor tissue severely hinders the penetration and enrichment of antitumor nanomedicines, which could significantly affect their efficiency. In this study, we used pH-sensitive nanocarriers loaded with collagenase (Col) to remold the tumor microenvironment (TME). Furthermore, we combined the collagenase delivery system with a nanomedicine to improve its penetration and enrichment in the tumor, thereby improving efficacy. We synthesized acetalated dextran (A...
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#1Zhaojie Zhou (Sichuan University)
#2Ling Zhang (Sichuan University)H-Index: 9
Last. Zhenmi Liu (Sichuan University)H-Index: 12
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Abstract Photodynamic therapy (PDT) is highly effective in treating tumors located near body surface, offering strong tumor suppression and low damage to normal tissue nearby. PDT is also effective for treating a number of other conditions. PDT not only provide a precise and selective method for the treatment of various diseases by itself, it can also be used in combination with other traditional therapies. Because PDT uses light as the unique targeting mechanism, it has simpler and more direct ...
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#1Yicong Zhang (Sichuan University)H-Index: 1
#2Yuai Li (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Metastasis is a major sign of malignant tumors which plays a vital role in cancer-related death. Suppressing metastasis is an important way to improve the survival rate of cancer patients. Herein, multifunctional PEG-LAM-PPS nanoparticles (nPLPs) are fabricated as both nanocarriers and anti-metastatic agents for tumor treatment. In this system, laminarin sulfate (LAM) suppresses metastasis by reducing heparinase and protecting the extracellular matrix; the ROS-sensitive polypropylene sulfide (PP...
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#1Y.P. Hou (Sichuan University)H-Index: 6
#2Ying Wang (Sichuan University)H-Index: 4
Last. Xun Sun (Sichuan University)H-Index: 50
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Abstract Adjuvants that contain pathogen-associated molecular patterns (PAMPs) can enhance vaccination efficacy by binding to pattern recognition receptors (PRRs), thereby stimulating immune responses. Particularly effective may be the combination of multiple PAMPs that activate different PRRs, which occurs with natural pathogens. Here we hypothesized the enhanced effects would occur in two adjuvants that stimulate different PRRs: CpG oligodeoxynucleotide (CpG-ODN), which is Toll-like receptor 9...
6 CitationsSource
#1Shiqi Huang (Sichuan University)H-Index: 4
#2Yicong Zhang (Sichuan University)H-Index: 1
Last. Ling Zhang (Sichuan University)H-Index: 9
view all 11 authors...
Abstract Malignant melanoma, a highly dangerous type of skin cancer, is usually resistant to pro-apoptosis agents such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) due to low death receptor expression levels. After verifying combination of chemotherapy drug paclitaxel (PTX) and TRAIL could significantly enhance their anti-melanoma effects, we developed a liposomal melanoma target-delivery system with tumor microenvironment responsiveness (TRAIL-[Lip-PTX]C18-TR) to co-delive...
7 CitationsSource