Nélida Simona Marin Huachaca
State University of Santa Cruz
PoloxamerMatrix (chemical analysis)CytotoxicityMicelleCircular dichroismDynamic light scatteringSolubilityBioavailabilityProteasesAqueous solutionChemistryIn vitroCombinatorial chemistryHybrid materialProteaseCarbon paste electrodeCyclic voltammetryPeptideDrug deliveryDifferential scanning calorimetryChemical engineeringCarbonCancer researchCarbon nanotubeElectrochemistryViability assayRedoxAmphiphileZeta potentialElectrophoretic light scattering
Publications 4
Saponins are bioactive compounds belonging to the secondary metabolism of plants widely used for their beneficial actions to human health. In this work the association of the saponin from Glycyrrhiza glabra with a matrix of multi-walled carbon nanotubes was promoted to obtain a composite material with improved functional characteristics. For this investigation, chemically modified electrodes (CME) based on carbon paste were developed. Firstly, a carbon paste electrode (CPE) modified with the add...
#1Natielle Cachoeira Dotivo (UCSC: University of California, Santa Cruz)H-Index: 2
#2Rachel Passos Rezende (UCSC: University of California, Santa Cruz)H-Index: 16
Last. João Carlos Teixeira Dias (UCSC: University of California, Santa Cruz)H-Index: 14
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Traditional therapy for malignant neoplasms involving surgical procedures, radiotherapy and chemotherapy aims to kill neoplastic cells, but also affects normal cells. Therefore, exogenous proteases are the target of studies in cancer therapy, as they have been shown to be effective in suppressing tumors and reducing metastases. Pluronic F127 (F127) is a copolymer of amphiphilic blocks that has shown significant potential for drug administration, as it is capable of incorporating hydrophobic drug...
#1Rosemaire S. S. de Oliveira (UCSC: University of California, Santa Cruz)H-Index: 1
#2Nélida Simona Marin Huachaca (UCSC: University of California, Santa Cruz)H-Index: 2
Last. Luiz C. Salay (UCSC: University of California, Santa Cruz)H-Index: 9
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Nanotechnology is important for the development of new materials capable to improve the development of novel drug delivery systems. Such systems may result in more efficient therapeutic effects with reduced toxicity and extended time in the organism and increase in bioavailability, biocompatibility, and solubility of drugs. Here it was investigated the interaction between the triblock copolymer Pluronic F127 (F127) and a natural bioactive amphiphilic saponin (SAP), extracted from Glycyrrhiza gla...
4 CitationsSource
#1Luiz C. Salay (UCSC: University of California, Santa Cruz)H-Index: 9
#2Elielma A. Prazeres (UCSC: University of California, Santa Cruz)H-Index: 1
Last. Eloi Feitosa (UNESP: Sao Paulo State University)H-Index: 24
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Triblock copolymers, such as Pluronic F127 (F127), are pharmaceutically important amphiphilic compounds that self-assemble in aqueous solution either as discrete or entangled micelles, depending on their concentration and temperature, which may function as drug delivery vehicle. Herein, we have synthesized the antimicrobial peptide tritrpticin (TRP3), a tryptophan (Trp)- and arginine (Arg)-rich peptide, sequence VRRFPWWWPFLRR, with a broad spectrum of action against bacteria and fungi, to invest...
2 CitationsSource