Errol P. Prens
Erasmus University Medical Center
Internal medicineSurgeryPathologyMolecular biologyDermatologyRandomized controlled trialTumor necrosis factor alphaImmunologyHidradenitis suppurativaInflammationCytokineDiseaseMEDLINEAdalimumabPsoriasisPathogenesisSeverity of illnessMedicineBiologyImmune system
Publications 245
#1Christos C. ZouboulisH-Index: 100
#2John W. Frew (Liverpool Hospital)H-Index: 17
Last. Errol P. PrensH-Index: 54
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The registration of the tumour necrosis factor-α inhibitor adalimumab in 2015 was a major step forward in the treatment of hidradenitis suppurativa/acne inversa (HS). However, it soon became evident that the effectiveness of adalimumab in daily practice was highly variable. A significant unmet medical need of HS patients remained, and the search for novel therapeutic targets was intensified. During the 10th European Hidradenitis Suppurativa Foundation (EHSF) e.V. Conference, reknown internationa...
1 CitationsSource
The reported incidence of COVID-19 among cohorts of patients with inflammatory bowel and skin diseases under treatment with biologicals is low. Treatment may further modify disease severity as some biological modifiers, such as anakinra, are also proposed for the management of COVID-19 patients potentially providing HS patients with an advantage. The above preliminary evidence suggests that hidradenitis suppurativa (HS) does probably not provide an increased susceptibility for COVID-19 and that ...
#1Kelsey R. van Straalen (Erasmus University Medical Center)H-Index: 6
#1K R van Straalen (Erasmus University Medical Center)H-Index: 5
Last. Barbara Horváth (UMCG: University Medical Center Groningen)H-Index: 29
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1 CitationsSource
#1Matthew Patrick (UM: University of Michigan)H-Index: 11
#2H. Zhang (UM: University of Michigan)H-Index: 1
Last. Lam C. Tsoi (UM: University of Michigan)H-Index: 28
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Abstract Background COVID-19 is commonly associated with skin manifestations, and may also exacerbate existing skin diseases, yet the relationship between COVID-19 and skin diseases remains unclear. Objective By investigating this relationship through a multi-omics approach, we sought to ascertain whether patients with skin conditions are more susceptible to COVID-19. Methods We conducted an epidemiological study and then compared gene expression across nine different inflammatory skin condition...
1 CitationsSource
#1L.M. Prens (UMCG: University Medical Center Groningen)H-Index: 1
#2K. Bouwman (UMCG: University Medical Center Groningen)
Last. Errol P. Prens (EUR: Erasmus University Rotterdam)H-Index: 54
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BACKGROUND Biologics are often required for treatment of hidradenitis suppurativa (HS). However, data on the drug survival of biologics in daily practice are currently lacking. OBJECTIVES To assess the drug survival of anti-TNF biologics in a daily practice cohort of HS patients and to identify predictors for drug survival. METHODS A retrospective multicenter study was performed in two academic dermatology centers in The Netherlands. Adult HS patients using biologics between 2008 and 2020 were i...
#1C B Ardon (EUR: Erasmus University Rotterdam)H-Index: 4
#2C. Wang (Erasmus University Medical Center)H-Index: 1
Last. K R van Straalen (EUR: Erasmus University Rotterdam)H-Index: 5
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Most of the currently available cytokine and antimicrobial peptide (AMP) expression data from Hidradenitis suppurativa (HS) lesions have been obtained through painful, invasive sampling techniques such as biopsies.1 In contrast, a Transdermal Analysis Patch (TAP, FibroTx, Tallinn, Estonia) captures and measures biomarkers at the skin surface and as such represents a novel, non-invasive, and patient-friendly diagnostic tool for skin biomarker detection. The aim of this study was to measure the le...
1 CitationsSource
#1Suk Yee Lam (Erasmus University Medical Center)H-Index: 1
#2Djawad Radjabzadeh (Erasmus University Medical Center)H-Index: 1
Last. Maikel P. Peppelenbosch (Erasmus University Medical Center)H-Index: 86
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#1Christos C. ZouboulisH-Index: 100
#2Farida Benhadou (ULB: Université libre de Bruxelles)H-Index: 9
Last. Hessel H. van der Zee (EUR: Erasmus University Rotterdam)H-Index: 12
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The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to d...
4 CitationsSource
#1K R van Straalen (EUR: Erasmus University Rotterdam)H-Index: 5
#2Sylke Schneider-Burrus (Charité)H-Index: 12
Last. Errol P. Prens (EUR: Erasmus University Rotterdam)H-Index: 54
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: This scholarly review on the current and future treatment of hidradenitis suppurativa (HS) focuses on medical and surgical treatment options, while novel pipeline drugs are also discussed. Treatment goals are to limit the incidence and duration of flares, reducing inflammation and suppuration, achieving local cure after surgery and, most importantly, to improve the quality of life of patients with HS. The type of medication and/or surgery should be chosen based on the stage of the disease and ...
7 CitationsSource
#1Kelsey R. van Straalen (EUR: Erasmus University Rotterdam)H-Index: 6
#2Errol P. Prens (EUR: Erasmus University Rotterdam)H-Index: 54
Last. H.H. van der Zee (EUR: Erasmus University Rotterdam)H-Index: 17
view all 5 authors...
Importance Hidradenitis suppurativa is a chronic, inflammatory skin disease in which genetic factors are considered to play a role, with up to 38% of patients reporting a family history. Variations in the γ-secretase genes are found mainly in familial cases with an autosomal dominant pattern of inheritance. These variations are rare in the general population with hidradenitis suppurativa, even in patients who report a family history of the disease. Objective To assess the heritability of hidrade...
1 CitationsSource