Timothy A. Joseph
Mayo Clinic
PathophysiologyInternal medicineRadiologySurgeryPerfusionCardiologyRetrospective cohort studyHemodynamicsClosure (topology)Predictive value of testsHaemodynamic responseStress testingCompliance (physiology)ArteryCardiac catheterizationAppropriate Use CriteriaMitral valveFractional flow reserveHeart failureCoronary artery diseaseRestenosisStentProsthesisCardiac surgeryArtifact (error)Degeneration (medical)MEDLINEValve replacementSingle CenterRegurgitation (circulation)AngioplastyPercutaneous coronary interventionExcimer laserAortic valvePercutaneousCatheterAortic valve stenosisPopulationIntracardiac pressurePercutaneous techniquesCoronary atherectomySEVERE DYSFUNCTIONElective Surgical ProcedurePhysiologic measurementPulse frequencyBioprosthetic valveMitral regurgitationProsthetic valveMechanical valveCoronary revascularizationTarget lesion revascularizationIn patientParavalvular leakTranscatheter aorticCoronary angiographyValve in valveLong term outcomesValve in ringBalloon expandable stentIncidence (epidemiology)Conventional PCIDiastoleMedicine
12Publications
3H-index
17Citations
Publications 12
Newest
#1John Nan (Mayo Clinic)H-Index: 1
#2Timothy A. JosephH-Index: 3
Last. Rajiv GulatiH-Index: 45
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AIMS Excimer Laser Coronary Angioplasty with adjunctive contrast (ELCA-con) is described as one potential option to facilitate intra-coronary stent expansion; however, the benefits and risks of this technology remain incompletely understood. We performed a retrospective single center study to evaluate procedural success, risks, and clinical outcomes of ELCA-con assisted percutaneous coronary intervention (PCI) for stent under-expansion. METHODS AND RESULTS Twenty-six consecutive patients underwe...
1 CitationsSource
#1Timothy A. JosephH-Index: 3
#2Mackram F. EleidH-Index: 33
Abstract: Mitral valve disease is the most prevalent cardiac valvular disorder, with many patients requiring repeat procedures for failing prosthetic valves or severe dysfunction after the surgical annuloplasty ring. Traditional surgical approaches are associated with increased morbidity and mortality in this aging and increasingly frail population. Recent advances in percutaneous techniques have allowed for minimally invasive valve-in-valve and valve-in-ring procedures to avoid major cardiac su...
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#1Timothy A. Joseph (Mayo Clinic)H-Index: 3
#2C. Charles Jain (Mayo Clinic)H-Index: 4
Last. Rick A. Nishimura (Mayo Clinic)H-Index: 128
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#1Timothy A. Joseph (Mayo Clinic)H-Index: 3
#2Park P. Zheng (Mayo Clinic)H-Index: 1
Last. Mackram F. Eleid (Mayo Clinic)H-Index: 33
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Paravalvular leak (PVL) is associated with worse outcomes following transcatheter aortic valve replacement (TAVR), rates of PVL have decreased over time with new valve designs, however less is known about the differences in PVL by valve size and how degree of over/under sizing may effect PVL.
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#1James W. Lloyd (Mayo Clinic)H-Index: 3
#2Timothy A. Joseph (Mayo Clinic)H-Index: 3
Last. Mackram F. Eleid (Mayo Clinic)H-Index: 33
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OBJECTIVE: To understand the clinical and hemodynamic response of patients with stenotic versus regurgitant prosthetic mitral valve degeneration to transseptal transcatheter mitral valve-in-ring/-valve replacement (TMVR). BACKGROUND: Patients with prosthetic mitral valve repair/replacement failure frequently present high-risk surgical challenges. TMVR has been employed as an alternative to surgery. METHODS: Forty-four patients with stenotic/regurgitant degeneration of prior prosthetic mitral ann...
5 CitationsSource
#1Timothy A. Joseph (Mayo Clinic)H-Index: 3
#2Mackram F. Eleid (Mayo Clinic)H-Index: 33
Last. Charanjit S. Rihal (Mayo Clinic)H-Index: 96
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OBJECTIVES: This study reports long-term outcomes percutaneous Melody valve (Medtronic, Minneapolis, Minnesota) valve-in-valve therapy in patients with prosthetic valve dysfunction. BACKGROUND: Repeat valve surgery is associated with high morbidity and mortality. Transcatheter mitral valve-in-valve is a promising alternative in patients at high-risk for cardiac surgery. METHODS: We conducted a retrospective cohort analysis of 13 patients who underwent Melody valve-in-valve for bioprosthetic dysf...
2 CitationsSource
Excimer laser (EL) has re-emerged as a tool for complex coronary intervention in two scenarios. First, for treatment of stent under expansion, where EL coupled with contrast is used to ablate tissue external to the stent as demonstrated in small case series and secondly, for the modification of
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#1Bradley Kay (UM: University of Michigan)
#2Timothy A. Joseph (Mayo Clinic)H-Index: 3
Last. Brahmajee K. Nallamothu (UM: University of Michigan)H-Index: 94
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Abstract Fractional flow reserve (FFR) is a physiologic measurement of coronary artery perfusion. Studies have demonstrated its benefit in lowering cost and improving outcomes in patients undergoing elective coronary angiography, though follow-up surveys have demonstrated low usage nationwide. We sought to investigate the actual usage in elderly patients undergoing elective coronary angiography. Overall utilization of FFR for elective coronary angiography was 6.3%. Age, sex, race, prior stress t...
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#1Timothy A. Joseph (Mayo Clinic)H-Index: 3
#2Colleen E. Lane (Mayo Clinic)H-Index: 2
Last. Charanjit S. Rihal (Mayo Clinic)H-Index: 96
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ABSTRACTIntroduction: Significant paravalvular leak (PVL) complicates between 6% and 15% of valve replacements and can result in heart failure and hemolysis. Paravalvular leak can be effectively treated with repeat surgery; however, these procedures are associated with significant operative morbidity. Percutaneous PVL closure is increasingly being utilized as the first line therapy for symptomatic patients, but efficacy may be limited by the lack of dedicated closure devices.Areas covered: This ...
5 CitationsSource
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