Dohgyu Hwang
Iowa State University
Self-healing hydrogelsInkwellMetamaterialLength scaleElasticity (economics)SignalSurface modificationSubstrate (chemistry)BiophysicsCleanroomFluidicsHaptotaxisWettingDeformation monitoringCell migrationDeformation (engineering)Density functional theoryChemical physicsComposite materialRigidity (electromagnetism)NanotechnologyActuatorChemistryExtracellular matrixMaterials scienceDeformation (meteorology)AcousticsDurotaxisSoft roboticsTumor microenvironmentRigidity (psychology)Hyaluronic acidBiomaterialJammingStiffnessDrug deliveryStretchable electronicsGellan gumExtracellularCell morphologyResonant sensorCytokine secretionGrapheneCo2 adsorptionFluid transportCollagen networkFractalMembraneFracture (geology)Nanoscopic scaleOptoelectronicsWirelessFracture mechanicsContact angleAdhesiveDelaminationFlexural rigidityMechanotaxisMechanical engineeringAdhesionAnisotropyCell adhesionMicrofluidicsProtein adsorptionCancer cell
12Publications
5H-index
83Citations
Publications 12
Newest
#1Shalini R. Unnikandam Veettil (Iowa State University)H-Index: 1
#2Dohgyu Hwang (Iowa State University)H-Index: 5
Last. Ian C. Schneider (Iowa State University)H-Index: 14
view all 0 authors...
Abstract null null Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness. While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery. The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is cu...
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#1Cole B. Haverkamp (Iowa State University)H-Index: 1
#2Dohgyu Hwang (VT: Virginia Tech)H-Index: 5
Last. Michael D. Bartlett (VT: Virginia Tech)H-Index: 20
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Controlling delamination across a material interface is a foundation of adhesive science and technology. This ranges from creating permanent, strong adhesives which limit crack propagation to reversible adhesives which initiate cracks for release. Methods which dynamically control cracks can lead to more robust adhesion, however specific control of crack initiation, propagation, and arresting is challenging because time scales of crack propagation are much faster than times scales of mechanisms ...
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#1Zihao Xu (Iowa State University)H-Index: 4
#2Dohgyu Hwang (Iowa State University)H-Index: 5
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
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Abstract Adhesion of macrophages to material substrates plays an essential role in many biological behaviors and biomedical procedures, including wound healing, cancer treatment and biomaterial implantation. Therefore, altering the adhesion of macrophages using biomaterial design may help control their biological function. In this work, we developed a straightforward method to render the hydrogel surface more hydrophobic and demonstrated that the adhesion of macrophages on hydrogels was enhanced...
2 CitationsSource
#2Dohgyu HwangH-Index: 5
Last. Jonathan C. ClaussenH-Index: 28
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Open microfluidics have emerged as a low-cost, pumpless alternative strategy to conventional microfluidics for delivery of fluid for a wide variety of applications including rapid biochemical analysis and medical diagnosis. However, creating open microfluidics by tuning the wettability of surfaces typically requires sophisticated cleanroom processes that are unamenable to scalable manufacturing. Herein, we present a simple approach to develop open microfluidic platforms by manipulating the surfa...
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#1Matthew D. Swift (Iowa State University)H-Index: 1
#2Cole B. Haverkamp (Iowa State University)H-Index: 1
Last. Michael D. Bartlett (Iowa State University)H-Index: 20
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2 CitationsSource
#1Dohgyu HwangH-Index: 5
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#1Zihao Xu (Iowa State University)H-Index: 4
#2Dohgyu Hwang (Iowa State University)H-Index: 5
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
view all 5 authors...
A balance of macrophage phenotypes is essential in successful implantation. Therefore, biomaterials should be carefully designed to better regulate the response of macrophages. We demonstrate macrophage adhesion and phenotypic shifts can be modulated with hydrophobically modified hydrogels. This study represents a fundamental concept in controlling cell adhesion and differentiation with substrate hydrophobicity. Gel synthesis was carried out using methacrylated gellan gum (MGG), which was polyme...
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#1Shalini R. Unnikandam Veettil (Iowa State University)H-Index: 1
#2Shawn Van Bruggen (Iowa State University)H-Index: 2
Last. Ian C. Schneider (Iowa State University)H-Index: 14
view all 5 authors...
Abstract Cancer cells have a tremendous ability to sense and respond to extracellular matrix (ECM) stiffness, modulating invasion. The magnitude of the sensed stiffness can either promote or inhibit the migration of cancer cells out of the primary tumor into surrounding tissue. Work has been done on examining the role of stiffness in tuning cancer cell migration by controlling elastic modulus in the bulk. However, a powerful and complementary approach for controlling stiffness is to leverage int...
3 CitationsSource
#1Sadaf Charkhabi (Iowa State University)H-Index: 3
#2Yee Jher Chan (Iowa State University)H-Index: 2
Last. Nigel F. Reuel (Iowa State University)H-Index: 22
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3 CitationsSource
#1Dohgyu Hwang (Iowa State University)H-Index: 5
#2Michael D. Bartlett (Iowa State University)H-Index: 20
Inspired by the art of paper cutting, kirigami provides intriguing tools to create materials with unconventional mechanical and morphological responses. This behavior is appealing in multiple applications such as stretchable electronics and soft robotics and presents a tractable platform to study structure-property relationships in material systems. However, mechanical response is typically controlled through a single or fractal cut type patterned across an entire kirigami sheet, limiting deform...
31 CitationsSource