Jong Hyun Lee
Kyung Hee University
PhosphorylationSTAT proteinKinaseChemistryApoptosisSurvivinSTAT3Stat3 Signaling PathwayCancer researchp38 mitogen-activated protein kinasesCarcinogenesisMAPK/ERK pathwayCell growthProtein kinase BProtein tyrosine phosphataseTranscription factorPI3K/AKT/mTOR pathwayBiologyCancer cellPharmacology
41Publications
21H-index
1,197Citations
Publications 37
Newest
#1Jong Hyun Lee (Kyung Hee University)H-Index: 21
#2Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 21
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 12 authors...
: Hepatocellular carcinoma (HCC) is a major malignancy that stands second in terms of global cancer-related mortality. STAT3 has been described as a latent transcription factor that promotes tumorigenesis. This study was designed to examine the effect of vitexin on STAT3 signaling and important hallmarks of cancer. HCC cells were employed to decipher the impact of vitexin on activation of STAT3 signaling using Western blotting, EMSA, immunocytochemistry, and reporter assay. The combinational apo...
13 CitationsSource
#1Jong Hyun Lee (Kyung Hee University)H-Index: 21
#2Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 21
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 15 authors...
Abstract Epithelial-mesenchymal transition (EMT) is a process of transdifferentiation where epithelial cells attain mesenchymal phenotype to gain invasive properties and thus, can contribute to metastasis of tumor cells. Here, we investigated the antimetastatic and antitumor efficacy of brusatol (BT) in a hepatocellular carcinoma (HCC) model. BT reduced the growth and invasive potential of HCC cells. We evaluated the action of BT on EMT-related proteins and found that BT restored the expression ...
21 CitationsSource
#1Shanaya Ramchandani (University of Melbourne)H-Index: 2
#2Irum Naz (Higher Education Commission of Pakistan)H-Index: 7
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 5 authors...
Cancer persists as one of the leading causes of deaths worldwide, contributing to approximately 9.6 million deaths per annum in recent years. Despite the numerous advancements in cancer treatment, there is still abundant scope to mitigate recurrence, adverse side effects and toxicities caused by existing pharmaceutical drugs. To achieve this, many phytochemicals from plants and natural products have been tested against cancer cell lines in vivo and in vitro. Likewise, casticin, a flavonoid extra...
7 CitationsSource
#1Jong Hyun Lee (Kyung Hee University)H-Index: 21
#2Arunachalam Chinnathambi (KSU: King Saud University)H-Index: 22
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 6 authors...
Abstract Epithelial mesenchymal transition (EMT) refers to a phenomenon through which epithelial cells develop the metastatic and invasive potential, which are closely related to carcinogenesis. Farnesol (FOH) obtained from the oils of diverse plants can exhibit significant therapeutic actions against obesity, diabetes, inflammatory conditions and cancers. Here, we evaluated the potential effects of FOH on growth and metastasis and it was observed that FOH significantly abrogated cell proliferat...
40 CitationsSource
#1Soo Dong Kim (Kyung Hee University)H-Index: 1
#2Jong Hyun Lee (Kyung Hee University)H-Index: 21
Last. Boyoung Y. Park (Kyung Hee University)H-Index: 3
view all 4 authors...
5 CitationsSource
#1Chulwon Kim (Kyung Hee University)H-Index: 27
#2Jun Ji (Hallym University)H-Index: 1
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 9 authors...
AbstractContext: Citrus unshiu Markovich (Rutaceae) peel is known to contain high concentrations of flavonoids and exerts pharmacological effects on antioxidant, anti-inflammation, allergies, diabe...
5 CitationsSource
#1Jong Hyun Lee (Kyung Hee University)H-Index: 21
#2Chulwon Kim (Kyung Hee University)H-Index: 27
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 12 authors...
: Casticin (CTC), one of the major components of Vitex rotundifolia L., has been reported to exert significant beneficial pharmacological activities and can function as an antiprolactin, anticancer, anti-inflammatory, neuroprotective, analgesic, and immunomodulatory agent. This study aimed at investigating whether the proapoptotic effects of CTC may be mediated through the abrogation of signal transducers and activators of transcription-3 (STAT3) signaling pathway in a variety of human tumor cel...
16 CitationsSource
#1Sun Tae Hwang (Kyung Hee University)H-Index: 4
#2Chulwon Kim (Kyung Hee University)H-Index: 27
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 8 authors...
Abstract Background Cycloastragenol (CAG), a triterpene aglycone is commonly prescribed for treating hypertension, cardiovascular disease, diabetic nephropathy, viral hepatitis, and various inflammatory-linked diseases. Hypothesis We investigated CAG for its action on signal transducer and activator of transcription 3 (STAT3) activation cascades, and its potential to sensitize gastric cancer cells to paclitaxel-induced apoptosis. Methods The effect of CAG on STAT3 phosphorylation and other hallm...
20 CitationsSource
#1Min Hee Yang (Kyung Hee University)H-Index: 6
#2Jong Hyun Lee (Kyung Hee University)H-Index: 21
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 6 authors...
The epithelial–mesenchymal transition (EMT) is a phenomenon that facilitates epithelial cells to acquire invasive potential to induce the initiation the metastatic spread of tumor cells. Here, we determined if brassinin (BSN) can affect the EMT process and deciphered its anti-cancer effects. BSN attenuated the levels of EMT linked genes and suppressed transforming growth factor beta (TGF-β)-mediated regulation of diverse mesenchymal markers. Additionally, BSN did increase the expression of vario...
24 CitationsSource
#1Jong Hyun Lee (Kyung Hee University)H-Index: 21
#2Chulwon Kim (Kyung Hee University)H-Index: 27
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 6 authors...
Abstract Background Arctiin is a main component from the fruits of Arctium lappa L., that can be prescribed for cold or flu in East Asian countries; it has also been found to exert chemopreventive actions against various tumor cells. Hypothesis In view of this evidence, we examined arctiin for its ability to trigger apoptosis and inhibit the activation of signal transducer and activator of transcription 3 (STAT3) in human multiple myeloma (MM) cells. Methods We evaluated the effect of arctiin on...
21 CitationsSource