Xun Hu
Sichuan University
CytotoxicityTargeted drug deliveryChemistryTraditional Chinese medicineIn vitroIn vivoInflammationCelastrolDerivative (chemistry)Drug deliveryKidneySpleenAcute Renal InjuryToxicityDisease progressionMedicinePharmacology
Publications 2
#1Qing Lin (University of Cambridge)H-Index: 2
#2Mengke Qu (Sichuan University)H-Index: 8
Last. Zhirong Zhang (Sichuan University)H-Index: 67
view all 13 authors...
Abstract Ethnopharmacological relevance Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in anti-tumor therapies. Imperialine is one of the most favored ...
#1Xun Hu (Sichuan University)H-Index: 2
#2Mengdi Jia (Sichuan University)H-Index: 5
Last. Qing Lin (Sichuan University)H-Index: 12
view all 6 authors...
: This study aimed to novelly design and synthesize an amide derivative as a potential substitute of celastrol (CLT). We constituted the compound celastrol-glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to celastrol (CLT) and confirmed its chemical structure by 1H NMR, 13C NMR, and LC-MS/MS. Then, the potential efficacy of the CLG was investigated on renal ischemia-reperfusion injury animal models. The results demonstrated that the decorated compound CLG could completely revers...
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