Giulia Carli
Vita-Salute San Raffaele University
DopaminergicNeuropsychologyPsychologyNeuroscienceCognitionVulnerabilityPediatricsPositron emission tomographyREM sleep behavior disorderNeurodegenerationSynucleinopathiesDementia with Lewy bodiesFrontotemporal dementiaLewy bodyDiseaseDementiaParkinson's diseaseNeuropathologyParasomniaCognitive declineAlzheimer's diseaseClinical trialNeuropsychological assessmentNeuroimagingCognitive reserveMedicineBiomarker (medicine)
14Publications
4H-index
65Citations
Publications 17
Newest
#1Andrea Galbiati (UniSR: Vita-Salute San Raffaele University)H-Index: 14
#2Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
Last. Luigi Ferini-Strambi (UniSR: Vita-Salute San Raffaele University)H-Index: 86
view all 8 authors...
Underlying neural mechanisms and cognitive implications of non-Rapid Eye Movement (NREM) sleep in isolated Rapid Eye Movement (REM) sleep behavior disorder (iRBD) are not yet fully elucidated. This study aims to evaluate brain metabolic connectivity of the anterior default mode network (ADMN) underlying a waveform that is an hallmark of NREM sleep, namely K-complex (KC) and their implication for neuropsychological functioning in iRBD patients. Combining polysomnographic and multivariate molecula...
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#1Silvia Paola Caminiti (UniSR: Vita-Salute San Raffaele University)H-Index: 14
#2Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
Last. Daniela Perani (UniSR: Vita-Salute San Raffaele University)H-Index: 98
view all 5 authors...
Background null Glucosylceramidase (GBA) mutations are considered the most common genetic risk factors for developing Parkinson's disease (PD). null Objectives null We aimed to assess, at different time points, the integrity of brain striatal and extra-striatal dopamine pathways and clinical phenotype of a group of PD subjects bearing heterozygous GBA mutations (GBA-PD), compared with a group of idiopathic PD patients (iPD) stratified by age at disease onset. A longitudinal approach was adopted ...
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#1Luca Beretta (UniSR: Vita-Salute San Raffaele University)H-Index: 3
#2Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
Last. Daniela Perani (UniSR: Vita-Salute San Raffaele University)H-Index: 98
view all 4 authors...
Visuo-constructive abilities are a multicomponential process that can be impaired in several neurodegenerative dementias. Among visuo-constructive tasks, the Rey-Osterrieth Complex Figure-copy (ROCF-c) is the most commonly used and it seems influenced by different skills mediated by specific brain regions. This task complexity allows exploring differential mechanisms of impairment in different neurodegenerative disorders. In this study we examined the neuroanatomical substrates of ROCF-c perform...
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#8Andrea Chincarini (INFN: Istituto Nazionale di Fisica Nucleare)H-Index: 112
Several radiotracers have been employed to bind amyloid plaques in the brain for the differential diagnosis of neurodegenerative disease, open the possibility to measure in vivo pathogenic processes implicated in Alzheimer disease (AD) and have the potential to detect disease processes at the earliest stages with a potential role in clinical trials’ longitudinal assessment. Visual reading is clinically adequate in clearly positive or negative cases but the adoption of validated and standardized ...
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#1Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
#2Cecilia Boccalini (UniSR: Vita-Salute San Raffaele University)H-Index: 3
Last. Daniela Perani (UniSR: Vita-Salute San Raffaele University)H-Index: 98
view all 7 authors...
Cognitive reserve (CR) delays cognitive decline due to neurodegeneration. Heterogeneous evidence suggests that education may act as CR in Dementia with Lewy Bodies (DLB). No data, however, are currently available on the role of occupation as proxy of CR in this neuropathology. Thirty-three patients with probable DLB were retrospectively included. We performed regression analyses models (TFCE p < 0.05) and seed-based interregional correlation analyses (p = 0.001, FWE-corrected at cluster-level) w...
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#1Giacomo Tondo (UniSR: Vita-Salute San Raffaele University)H-Index: 7
#2Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
view all 11 authors...
BACKGROUND The amnestic presentation of mild cognitive impairment (aMCI) represents the most common prodromal stage of Alzheimer's disease (AD) dementia. There is, however, some evidence of aMCI with typical amnestic syndrome but showing long-term clinical stability. The ability to predict stability or progression to dementia in the aMCI condition is important, particularly for the selection of candidates in clinical trials. We aimed to establish the role of in vivo biomarkers, as assessed by ce...
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#1Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
#2Giacomo Tondo (UniSR: Vita-Salute San Raffaele University)H-Index: 7
Last. Daniela Perani (UniSR: Vita-Salute San Raffaele University)H-Index: 98
view all 4 authors...
Positron emission tomography (PET) allows for the in vivo assessment of early brain functional and molecular changes in neurodegenerative conditions, representing a unique tool in the diagnostic workup. The increased use of multivariate PET imaging analysis approaches has provided the chance to investigate regional molecular processes and long-distance brain circuit functional interactions in the last decade. PET metabolic and neurotransmission connectome can reveal brain region interactions. Th...
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#1Cecilia Boccalini (UniSR: Vita-Salute San Raffaele University)H-Index: 3
#2Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
Last. Daniela Perani (UniSR: Vita-Salute San Raffaele University)H-Index: 98
view all 5 authors...
Background: In Parkinson’s disease (PD), neurodegeneration of dopaminergic systems leads to motor and non-motor abnormalities. Sex might influence the clinical PD phenotypes and progression. Previo...
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#1Daniela Perani (UniSR: Vita-Salute San Raffaele University)H-Index: 98
#2Silvia Paola Caminiti (UniSR: Vita-Salute San Raffaele University)H-Index: 14
Last. Giacomo Tondo (UniSR: Vita-Salute San Raffaele University)H-Index: 7
view all 4 authors...
In neurodegenerative diseases, several studies have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice versa, that similar clinical phenotypes can be triggered by different underlying neuropathologies. This evidence called for the adoption of a pathology spectrum-based approach. Conditions belonging to the same or different spectrum of diseases share brain deposition of abnormal protein aggregates, which lead to aberrant biochemical, metaboli...
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#1Giacomo Tondo (UniSR: Vita-Salute San Raffaele University)H-Index: 7
#2Giulia Carli (UniSR: Vita-Salute San Raffaele University)H-Index: 4
Last. Daniela PeraniH-Index: 98
view all 10 authors...
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