Taiyu Shen
Jilin University
Messenger RNAInternal medicinePeroxisomeEndocrinologyPyrin domainUnfolded protein responseLipolysisGene expressionWhite adipose tissueEndoplasmic reticulumProinflammatory cytokineAdipose tissueHepatic stellate cellTumor necrosis factor alphaKinaseChemistryAutophagyHaptoglobinLipid dropletGrowth factorOxidative stressAdipocyteSteatosisLactationKetosisPINK1InflammationBECN1Glutamate dehydrogenaseInflammasomeParkinMetabolic disorderCytokineFatty liverTriglycerideATF6MitophagyPalmitic acidPropionateDry matterATG12ATG5Hormone-sensitive lipaseMitochondrionLiver functionBlood chemistryCellular homeostasisJanus kinase 2LipotoxicityLipid metabolismFatty acid synthaseViability assaySerum amyloid AOxidative phosphorylationMetabolismInterleukin 18IntracellularBiologyPharmacology
9Publications
5H-index
122Citations
Publications 9
Newest
#1Wenwen Gao (JLU: Jilin University)H-Index: 5
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Xiliang Du (JLU: Jilin University)H-Index: 12
view all 17 authors...
Negative energy balance-induced high blood concentrations of free fatty acids during the early postpartum period in dairy cows is a major cause of liver injury. Cows in severe negative energy balance often have suboptimal intakes of feed, which contributes to shortfalls in production of ruminal propionate and circulating glucose. Although increasing propionate production by the rumen through feed additives such as propylene glycol is effective in helping cows alleviate the shortfall in dietary e...
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#1Fan Minghe (JLU: Jilin University)
#2Xiliang Du (JLU: Jilin University)H-Index: 12
Last. Wenwen Gao (JLU: Jilin University)H-Index: 5
view all 16 authors...
ABSTRACT Dairy cows with ketosis exhibit signs of pronounced adipose tissue lipolysis and systemic inflammation, both of which exacerbate this metabolic disorder. In nonruminants, CIDEC plays a pivotal role in the formation of large unilocular lipid droplets. The present study aimed to ascertain the role of CIDEC in the lipolytic and inflammatory response of white adipose tissue (WAT) in vivo and in vitro. Subcutaneous adipose tissue and blood samples were collected from 15 healthy cows (blood β...
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#1Taiyu Shen (JLU: Jilin University)H-Index: 5
#2Feng Xu (JLU: Jilin University)H-Index: 1
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 17 authors...
ABSTRACT Severe negative energy balance around parturition is an important contributor to ketosis, a metabolic disorder that occurs most frequently in the peripartal period. Autophagy and mitophagy are important processes responsible for breaking down useless or toxic cellular material, and in particular damaged mitochondria. However, the role of autophagy and mitophagy during the occurrence and development of ketosis is unclear. The objective of this study was to investigate autophagy and mitop...
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#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Zhen Shi (JLU: Jilin University)H-Index: 10
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 15 authors...
BACKGROUND AND PURPOSE: Identifying safe and effective compounds that target to mitophagy to eliminate impaired mitochondria may be an attractive therapeutic strategy for NAFLD. Here, we investigated the effects of cyanidin-3-O-glucoside (C3G) on NAFLD and the underlying mechanism. EXPERIMENTAL APPROACH: NAFLD was induced by a high-fat diet (HFD) for 16 weeks. C3G was administered during the last 4 weeks. In vivo, recombinant adenoviruses and AAV8 were used for overexpression and knockdown of PT...
6 CitationsSource
#1Meng Chen (JLU: Jilin University)H-Index: 1
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
ABSTRACT During the transition period, dairy cows are challenged by increased energy demands and decreased dry matter intake, which can induce a variety of metabolic disorders, especially fatty liver. Dairy cows suffering from mild or moderate fatty liver in this period show no distinct clinical symptoms, indicating the occurrence of adaptive processes. The process of autophagy (an adaptive response) leads to degradation of intracellular components to generate energy and maintains cellular homeo...
1 CitationsSource
#1Taiyu Shen (JLU: Jilin University)H-Index: 5
#2Xinwei Li (JLU: Jilin University)H-Index: 23
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 11 authors...
ABSTRACT Ketosis is an important metabolic disease that can negatively affect the production efficiency of dairy cows. Earlier studies have revealed metabolic and inflammatory alterations in the blood associated with ketosis; however, a link between ketosis and hepatic inflammation has not been well documented. The objective of this study was to investigate whether the nuclear factor kappa B (NF-κB) signaling pathway and NLR family pyrin domain containing 3 (NLRP3) inflammasome were activated in...
10 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Taiyu Shen (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
ABSTRACT The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation of the hepatic metabolism to overcome metabolic stress. Fatty liver is one of the main health disorders after parturition. Therefore, to investigate changes in hepatic lipid metabolic status and mitochondria in dairy cows with mild fatty liver, liver and blood samples were collected from healthy cows (n = 15) and cows with mild fatty liver (n = 15). To determine the effects of palm...
34 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Yiwei Zhu (JLU: Jilin University)H-Index: 9
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 14 authors...
ABSTRACT The hepatic growth hormone (GH)–insulin-like growth factor (IGF)-I axis is essential for regulating intrahepatic lipid metabolism. Ketotic cows are characterized by high blood concentrations of fatty acids and β-hydroxybutyrate (BHB), which display lipotoxicity. The aim of this study was to investigate changes in the hepatic GH–IGF-I axis in ketotic cows and to determine the effects of fatty acids and BHB on the GH–IGF-I axis in calf hepatocytes. Liver and blood samples were collected f...
49 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 17 authors...
ABSTRACT The ability of liver to respond to changes in nutrient availability is essential for the maintenance of metabolic homeostasis. Autophagy encompasses mechanisms of cell survival, including capturing, degrading, and recycling of intracellular proteins and organelles in lysosomes. During negative nutrient status, autophagy provides substrates to sustain cellular metabolism and hence, tissue function. Severe negative energy balance in dairy cows is associated with fatty liver. The aim of th...
11 CitationsSource