Dinesh Kumar
National Institute of Science Education and Research
Gentamicin protection assayCancerPhenotypeElongation factorRegulation of gene expressionApoptosisDNA methylationImmunohistochemistryTranscriptional regulationProstateWestern blotEEF1A2MetastasisBrain tumorIQGAP1Triple-negative breast cancerProstate cancerEEF2Lymph nodeEEF1B2OncogeneTranslation factorEukaryotic translationCancer researchp38 mitogen-activated protein kinasesColorectal cancerBreast cancerCarcinogenesisMAPK/ERK pathwaySignal transductionMedicineEukaryotic translation elongation factor 1 alpha 1Estrogen receptorPI3K/AKT/mTOR pathwayBiologyEctopic expression
6Publications
2H-index
58Citations
Publications 7
Newest
#1Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
#2Saket Awadheshbhai Patel (NISER: National Institute of Science Education and Research)
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 6 authors...
Anti-angiogenesis cancer therapies are facing setbacks due to side effects and resistance. Parallel targeting of multiple pathways can help in the development of more effective therapies. This requires the discovery of new molecules which can regulate multiple cellular processes. Our study has recently established the association of reduced IQGAP2 expression in breast cancer with EMT and poor prognosis of the patient. Existing literature indirectly suggests the role of IQGAP2 in angiogenesis whi...
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#1Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
#2Saket Awadesbhai Patel (NISER: National Institute of Science Education and Research)H-Index: 1
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 6 authors...
IQGAP2, a member of the IQGAP family, functions as a tumor suppressor in most of the cancers. Unlike IQGAP1 and IQGAP3, which function as oncogenes in breast cancer, the role of IQGAP2 is still unexplored. Here we report a reduced expression of IQGAP2, which was associated with lymph node positivity, lymphovascular invasion, and higher age in breast cancer patients. We found an inverse correlation of IQGAP2 expression levels with oncogenic properties of breast cancer cell lines in estrogen recep...
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#1Md. Khurshidul Hassan (NISER: National Institute of Science Education and Research)H-Index: 3
#2Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 4 authors...
Abstract Aims Ever since EEF1A2's identification as a putative oncogene in breast cancer, it has stimulated curiosity due to its contrasting role in predicting the prognostic values in breast cancer patients. Contradicting reports suggest it to be playing a pro-survival as well as a negative role in the survival of patients. This prompted us to find the association of this protein with molecular subtypes in breast cancer and its effect on EMT in representative cell lines. Main methods Data-minin...
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#1Md. Khurshidul Hassan (NISER: National Institute of Science Education and Research)H-Index: 3
#2Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 6 authors...
Abstract Aims Glioblastomas are highly aggressive brain tumors with a very poor survival rate. EEF1A2, the proto-oncogenic isoform of the EEF1A translation factor family, has been found to be overexpressed and promoting tumorigenesis in multiple cancers. Interestingly, recent studies reported reduced expression of this protein in brain tumors, drawing our attention to find the functional role and mechanism of this protein in brain tumor progression. Main methods Using representative cell line as...
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#1Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
#2Md. Khurshidul Hassan (NISER: National Institute of Science Education and Research)H-Index: 3
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 5 authors...
IQGAP2 is a member of IQGAPs scaffolding protein family. It has been reported as a tumor suppressor in various cancers, as well as, an oncogene in some cancers, suggesting organ specific role. Need to identify therapeutic targets which function in ER/PR independent way, prompted us to explore role of IQGAP2 in molecular mechanism in breast cancer, which was completely unknown. In vitro studies in estrogen receptor positive breast cancer cell line (MCF7) showed that low IQGAP2 expression results ...
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#1Md. Khurshidul Hassan (NISER: National Institute of Science Education and Research)H-Index: 3
#2Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 4 authors...
Eukaryotic translation factors, especially initiation factors have garnered much attention with regards to their role in the onset and progression of different cancers. However, the expression levels and prognostic significance of translation elongation factors remain poorly explored in different cancers. In this study, we have investigated the mRNA transcript levels of seven translation elongation factors in different cancer types using Oncomine and TCGA databases. Furthermore, we have identifi...
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#1Dinesh Kumar (NISER: National Institute of Science Education and Research)H-Index: 2
#2Md. Khurshidul Hassan (NISER: National Institute of Science Education and Research)H-Index: 3
Last. Manjusha Dixit (NISER: National Institute of Science Education and Research)H-Index: 15
view all 5 authors...
IQGAPs is a family of proteins which comprises three members, in humans. The expression pattern and role of IQGAP1 has been well established in many cancers, whereas those of IQGAP2 and IQGAP3, have mostly remained unexplored. We used available large datasets, to explore the pan-cancer status of these two genes in-silico. Here we have analysed their mRNA expression and correlation with survivability in eight different cancers, including lung, breast, gastric, brain, colorectal, prostate, liver a...
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