Sheema Khan
University of Texas at Austin
CancerTargeted drug deliveryKinaseChemistryApoptosisIn vitroTumor microenvironmentProtein kinase D1PaclitaxelGlucose uptakePancreatic tumorPancaMetastasisProstate cancerPancreatic cancerDocetaxelCancer researchCarcinogenesisCell growthMedicineCell cultureBiologyCancer cellmTORC1
16Publications
4H-index
31Citations
Publications 15
Newest
#1Andrew E. Massey (NIH: National Institutes of Health)H-Index: 5
#1Andrew E. Massey (NIH: National Institutes of Health)
Last. Bilal Bin Hafeez (University of Texas at Austin)H-Index: 29
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Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implication...
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#1Ananya Dutta (U of M: University of Memphis)H-Index: 1
#2Bonny Banerjee (U of M: University of Memphis)H-Index: 11
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
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Background: Pancreatic cancer (PC) is a disease with poor prognosis and survival rate. There is a pertinent need to identify the risk factors of this disease. The purpose of this study is to use machine learning methods to identify a subset of factors (a.k.a. features) from the PLCO dataset as predictors of PC. The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer dataset is collected by the National Cancer Institute from 155,000 participants (49.5% male). Each participant responded to three ...
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#1Yoo-Duk Choi (Chonnam National University)H-Index: 16
#2Ji-Yeon Jung (Chonnam National University)H-Index: 15
Last. Mihwa Kim (University of Texas at Austin)H-Index: 6
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Pancreatic cancer is the worst exocrine gastrointestinal cancer leading to the highest mortality. Recent studies reported that aberrant expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is involved in uncontrolled cell growth. However, the molecular mechanism of APE1 biological role remains unrevealed in pancreatic cancer progression. Here, we demonstrate that APE1 accelerates pancreatic cancer cell proliferation through glial cell line-derived neurotrophic factor (GDNF)/glial f...
3 CitationsSource
#1Sonam Kumari (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#2Sheema Khan (University of Texas at Austin)H-Index: 4
Last. Meena Jaggi (University of Texas at Austin)H-Index: 1
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Protein kinase D1 (PKD1) is a serine–threonine kinase that regulates various functions within the cell. Herein, we report the significance of PKD1 expression in glucose metabolism resulting in pancreatic cancer (PanCa) progression and chemo-resistance. PKD1 expression in PanCa was investigated by using immunohistochemistry. Functional and metabolic assays were utilised to analyse the effect of PKD1 expression/knockdown on associated cellular/molecular changes. PKD1 expression was detected in hum...
3 CitationsSource
#1Andrew E. Massey (UT: University of Tennessee)H-Index: 5
#2Mohammed Sikander (UT: University of Tennessee)H-Index: 7
Last. Subhash C. Chauhan (UT: University of Tennessee)H-Index: 49
view all 13 authors...
Abstract Pancreatic cancer (PanCa) is a major cause of cancer-related death due to limited therapeutic options. As pancreatic tumors are highly desmoplastic, they prevent appropriate uptake of therapeutic payloads. Thus, our objective is to develop a next-generation nanoparticle system for treating PanCa. We generated a multi-layered Pluronic F127 and polyvinyl alcohol stabilized and poly-L-lysine coated paclitaxel loaded poly(lactic-co-glycolic acid) nanoparticle formulation (PPNPs). This formu...
4 CitationsSource
#1Mohammed SikanderH-Index: 7
#2Shabnam MalikH-Index: 8
Last. Meena Jaggi (UT: University of Tennessee)H-Index: 36
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Background: Cervical cancer (CxC) is a leading cause of mortality and morbidity among women worldwide. Current chemotherapeutic agents for CxC have shown systemic toxicity in CxC patients. Ormeloxifene (ORM) is a non-toxic and non-steroidal drug with well-defined pharmacokinetic and pharmacodynamic properties in humans. Studies have shown its anti-cancer potential in various pre-clinical mouse models. Here, we have synthesized and characterized a novel analogue of ormeloxifene, Bromo-ormeloxifen...
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#1Sonam KumariH-Index: 8
#2Sheema Khan (UT: University of Tennessee)H-Index: 4
Last. Meena JaggiH-Index: 36
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Objective: Pancreatic cancer (PanCa) is the third most common cause of cancer-related deaths in the US. Protein Kinase D1 (PKD1) is a kinase molecule which is involved in various important cellular signaling processes. While PKD1 has been reported to play a role in PanCa progression, the molecular mechanisms involved have not been adequately studied. Herein, we investigate the underlying mechanisms which enable PKD1 in enhancing glucose metabolism and further contribute to PanCa aggressiveness. ...
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#1Prashanth K.B. Nagesh (UT: University of Tennessee)H-Index: 10
#1Prashanth Kumar Bhusetty Nagesh (UT: University of Tennessee)H-Index: 1
Last. Murali M. Yallapu (UT: University of Tennessee)H-Index: 34
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Purpose: Prostate cancer (PrCa) is one of the leading causes of cancer-related deaths among men in the United States. Chemotherapy with docetaxel holds great promise and important therapeutic option for PrCa treatment. However, chemotherapy is often associated with incomplete cell death and leads to persistent senescent phenotype. Such phenotypic cancer cells survive and promotes tumor development, recurrence, and drug resistance. Altogether, targeting these cells can enhance chemotherapy outcom...
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#1Mohammed Sikander (UT: University of Tennessee)H-Index: 7
#2Shabnam Malik (UT: University of Tennessee)H-Index: 8
Last. Subhash C. ChauhanH-Index: 49
view all 12 authors...
Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastasis. Herein, we report that cucurbitacin D (Cuc D) effectively inhibits glucose uptake and lactate production in metastatic PrCa cells via modulating glucose metabolism. This metabolic shift by...
13 CitationsSource
#1Pallabita Chowdhury (UT: University of Tennessee)H-Index: 1
#2Sumeet S. ChauhanH-Index: 2
Last. Murali M. Yallapu (UT: University of Tennessee)H-Index: 34
view all 8 authors...
Objectives: Paclitaxel (Ptxl) is currently the most common first-line therapeutic option for breast cancer (BrCa). However, adverse side effects and problems associated with chemo-resistance, limits its use in clinical settings. Nanoparticle mediated delivery can improve Ptxl delivery and its activity at the tumor site, and considered to be an attractive strategy for BrCa therapy. Therefore, we aim to generate a novel Ptx medical nanoparticle formulation (PMNPs) using a polyphenol as a carrier, ...
4 CitationsSource