Carlos F. Aylwin
Oregon National Primate Research Center
PromoterGeneEnhancerExcitatory postsynaptic potentialJuvenileGene silencingInternal medicineEndocrinologyGene expressionNeuroscienceInhibitory postsynaptic potentialPsychological repressionArc (protein)Transcriptional regulationKisspeptinHypothalamusLuteinizing hormoneDemethylaseEpigeneticsEndocrine systemPeriod (gene)HistoneGene regulatory networkHormonePremovement neuronal activityChromatinBiologyMechanism (biology)Cell biology
14Publications
5H-index
96Citations
Publications 15
Newest
#1Silvia León (Harvard University)H-Index: 4
#2Rajae Talbi (Brigham and Women's Hospital)H-Index: 6
Last. Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
view all 12 authors...
Hypothalamic Kiss1 neurons control gonadotropin-releasing hormone (GnRH) release through the secretion of kisspeptin. Kiss1 neurons serve as a nodal center that conveys essential regulatory cues for the attainment and maintenance of reproductive function. Despite this critical role, the mechanisms that control kisspeptin synthesis and release remain largely unknown. Using Drop-Seq data from the arcuate nucleus of adult mice and in situ hybridization, we identified Nescient Helix-Loop-Helix 2 (Nh...
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#1Silvia León (Harvard University)H-Index: 4
#2Rajae Talbi (Harvard University)H-Index: 6
Last. Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
view all 12 authors...
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#1David Lopez-Rodriguez (University of Liège)H-Index: 2
#2Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
Last. Ezio Tirelli (University of Liège)H-Index: 23
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BACKGROUND The effects of endocrine-disrupting chemicals (EDCs) on fertility and reproductive development represent a rising concern in modern societies. Although the neuroendocrine control of sexual maturation is a major target of EDCs, little is known about the potential role of the hypothalamus in puberty and ovulation disruption transmitted across generations. OBJECTIVES We hypothesized that developmental exposure to an environmentally relevant dose of EDC mixture could induce multi- and/or ...
1 CitationsSource
#1Carlos Farkas (UdeC: University of Concepción)H-Index: 4
#2Aracelly Quiroz (UdeC: University of Concepción)
Last. Roxana Pincheira (UdeC: University of Concepción)H-Index: 15
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The SALL2 transcription factor, an evolutionarily conserved gene through vertebrates, is involved in normal development and neuronal differentiation. In disease, SALL2 is associated with eye, kidney, and brain disorders, but mainly is related to cancer. Some studies support a tumor suppressor role and others an oncogenic role for SALL2, which seems to depend on the cancer type. An additional consideration is tissue-dependent expression of different SALL2 isoforms. Human and mouse SALL2 gene loci...
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#1Hollis Wright (Oregon National Primate Research Center)H-Index: 7
#2Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
Last. Alejandro Lomniczi (Oregon National Primate Research Center)H-Index: 30
view all 5 authors...
Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1, a puberty-activating gene, is a key target of this silencing mechanism. Using a gain-of-function approach and a systems biology strategy we now show that EED, an essential PcG component, acts in the arcuate nucleus of the hypothalamus to alter the functional organization of a gene network involved in the stimulatory control of puberty. A central node of this network is Kdm6b, which encodes an enzyme th...
2 CitationsSource
#1Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
#2Alejandro Lomniczi (Oregon National Primate Research Center)H-Index: 30
Abstract In the arcuate nucleus (ARC) of the hypothalamus reside two neuronal systems in charge of regulating feeding control and reproductive development. The melanocortin system responds to metabolic fluctuations adjusting food intake, whereas kisspeptin neurons are in charge of the excitatory control of Gonadotropin Hormone Releasing Hormone (GnRH) neurons. While it is known that the melanocortin system regulates GnRH neuronal activity, it was recently demonstrated that kisspeptin neurons not...
1 CitationsSource
#1Ana Paula Abreu (Brigham and Women's Hospital)H-Index: 18
#2Carlos A. Toro (Oregon National Primate Research Center)H-Index: 12
Last. Ursula B. Kaiser (Brigham and Women's Hospital)H-Index: 69
view all 14 authors...
: The identification of loss-of-function mutations in MKRN3 in patients with central precocious puberty (CPP) in association with the decrease in MKRN3 expression in the medial basal hypothalamus (MBH) of mice prior to the initiation of reproductive maturation suggest that MKRN3 is acting as a 'brake' on GnRH secretion during childhood. In the current study, we investigated the mechanism by which MKRN3 prevents premature manifestation of the pubertal process. We showed that, as in mice, MKRN3 ex...
18 CitationsSource
#1David Lopez Rodriguez (University of Liège)
#2Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
Last. Anne-Simone Parent (University of Liège)H-Index: 25
view all 13 authors...
Female reproductive development and maternal behavior are two intertwined phenotypes centrally controlled by the hypothalamus. Endocrine disrupting chemicals (EDC) can alter these processes especially when animals are exposed during development. We propose the concept that developmental exposure to a low environmentally relevant dose of EDC mixture induces a transgenerational alteration of female rat pubertal timing and ovarian physiology throughout epigenetic reprograming of hypothalamic Kiss1,...
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#1Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
#2Alejandro Lomniczi (Oregon National Primate Research Center)H-Index: 30
During the last few years, new genes required for the advent of puberty have been identified thanks to the use of new deep sequencing associated technologies. Evidence has emerged suggesting that these genes, organized into functional networks, are regulated by a mechanism of epigenetic control. While the Polycomb group (PcG) of transcriptional repressors is in charge of the repressive arm of this mechanism, the Trithorax Group (TrxG) of epigenetic activators counteract the PcG-mediated silencin...
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#1Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 5
#2Carlos A. Toro (Oregon National Primate Research Center)H-Index: 12
Last. Alejandro Lomniczi (Oregon National Primate Research Center)H-Index: 30
view all 4 authors...
: The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge...
22 CitationsSource