Jean Addington
Allen Institute for Brain Science
StatisticsPsychiatryInternal medicineMental healthNoisePsychologyRandomized controlled trialYoung adultPsychological interventionLongitudinal studyDepression (differential diagnoses)MEDLINEPsychosisProdromeIntervention (counseling)Speech recognitionPopulationFirst episodeSchizophrenia spectrumClinical researchAnxietyClinical psychologyMedicineSchizophreniaRelative riskMeta-analysisSpurious relationship
14Publications
8H-index
84Citations
Publications 26
Newest
#1Wisteria DengH-Index: 1
#2Jean AddingtonH-Index: 8
Last. Ming T. TsuangH-Index: 3
view all 14 authors...
Objectives While co‐morbid depression is associated with poor functional outcome among patients with schizophrenia, whether depression similarly predicts poorer outcomes in individuals at clinical ...
Source
#1Michelle Worthington (Yale University)H-Index: 5
#2Jean Addington (Allen Institute for Brain Science)H-Index: 8
Last. Tyrone D. Cannon (Yale University)H-Index: 117
view all 14 authors...
The clinical high-risk period before a first episode of psychosis (CHR-P) has been widely studied with the goal of understanding the development of psychosis; however, less attention has been paid to the 75%-80% of CHR-P individuals who do not transition to psychosis. It is an open question whether multivariable models could be developed to predict remission outcomes at the same level of performance and generalizability as those that predict conversion to psychosis. Participants were drawn from ...
Source
#1Olga Santesteban-Echarri (Centre for Mental Health)H-Index: 12
#2Lu Liu (Centre for Mental Health)H-Index: 23
Last. Larry J. Seidman (Harvard University)H-Index: 140
view all 0 authors...
Source
#1Mohammed K. Shakeel (Allen Institute for Brain Science)H-Index: 3
#2Stefanie Hassel (Allen Institute for Brain Science)H-Index: 4
Last. Geoffrey B. HallH-Index: 33
view all 22 authors...
Abstract Identifying biomarkers of serious mental illness, such as altered white matter microstructure, can aid in early diagnosis and treatment. White matter microstructure was assessed using constrained spherical deconvolution of diffusion imaging data in a sample of 219 youth (age 12-25 years, 64.84% female) across 8 sites. Participants were classified as healthy controls (HC; n=47), familial risk for serious mental illness (n=31), mild-symptoms (n=37), attenuated syndromes (n=66), or discret...
Source
#1Michelle Worthington (Yale University)H-Index: 5
#2David J. Miklowitz (UCLA: University of California, Los Angeles)H-Index: 83
Last. Tyrone D. CannonH-Index: 117
view all 15 authors...
AIM: Recent findings suggest that family-focused therapy (FFT) is effective for individuals at clinical high-risk for psychosis (CHR-P). As outcomes of CHR-P individuals are quite varied, certain psychosocial interventions may be differentially effective in subgroups. The present study examined change in positive symptoms for CHR-P individuals at different levels of predicted risk for conversion to psychosis who received either FFT, a brief form of family education termed enhanced care (EC) or t...
Source
#1Loes M. Olde Loohuis (Semel Institute for Neuroscience and Human Behavior)H-Index: 22
#2Eva Mennigen (Semel Institute for Neuroscience and Human Behavior)H-Index: 14
Last. Roel A. Ophoff (Semel Institute for Neuroscience and Human Behavior)H-Index: 95
view all 21 authors...
Psychotic symptoms are not only an important feature of severe neuropsychiatric disorders, but are also common in the general population, especially in youth. The genetic etiology of psychosis symptoms in youth remains poorly understood. To characterize genetic risk for psychosis spectrum symptoms (PS), we leverage a community-based multiethnic sample of children and adolescents aged 8-22 years, the Philadelphia Neurodevelopmental Cohort (n = 7225, 20% PS). Using an elastic net regression model,...
Source
#1Michelle Worthington (Yale University)H-Index: 5
#2Elaine F. Walker (Emory University)H-Index: 77
Last. Tyrone D. Cannon (Yale University)H-Index: 117
view all 13 authors...
Abstract Background Risk calculators are useful tools that can help clinicians and researchers better understand an individual's risk of conversion to psychosis. The North American Prodrome Longitudinal Study (NAPLS2) Individualized Risk Calculator has good predictive accuracy but could be potentially improved by the inclusion of a biomarker. Baseline cortisol, a measure of hypothalamic-pituitary-adrenal (HPA) axis functioning that is impacted by biological vulnerability to stress and exposure t...
Source
#1Olga Santesteban-Echarri (Centre for Mental Health)H-Index: 12
#2Preston Haffey (U of C: University of Calgary)H-Index: 1
Last. Jean Addington (Centre for Mental Health)H-Index: 8
view all 5 authors...
Source
#1Daniel J. Devoe (U of C: University of Calgary)H-Index: 11
#2Megan S. Farris (U of C: University of Calgary)H-Index: 13
Last. Jean Addington (Centre for Mental Health)H-Index: 8
view all 4 authors...
OBJECTIVE: The primary objective of this systematic review and meta-analyses was to summarize the impact of all reported treatments on transition to psychosis in high-risk samples. DATA SOURCES: PsycINFO, Embase, CINAHL, EBM, and MEDLINE online databases were searched from inception to May 2017 using the keywords psychosis, risk, and treatment with no geographical, date, or language restrictions. STUDY SELECTION: A total of 38 independent studies met the inclusion criteria: conducted a treatment...
Source
#1Megan S. Farris (Centre for Mental Health)H-Index: 1
#2Mohammed K. Shakeel (Centre for Mental Health)H-Index: 1
Last. Jean Addington (Centre for Mental Health)H-Index: 8
view all 3 authors...
Purpose The objectives of this review were to understand the prevalence of cannabis use and how cannabis is associated with transition to psychosis, symptoms, cognition, trauma and family history in clinical high risk (CHR) for psychosis individuals.
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.