Kristine B. Walhovd
Oslo University Hospital
Developmental psychologyNeuropsychologyMagnetic resonance imagingHippocampal formationDiffusion MRIPsychologyNeuroscienceCognitionYoung adultCortex (anatomy)DiseaseCerebral cortexHippocampusAtrophyWhite matterAudiologyNeuroimagingMedicineBiologyEpisodic memoryFractional anisotropy
Publications 244
#1Donatas Sederevicius (University of Oslo)H-Index: 7
#2Didac Vidal-Piñeiro (University of Oslo)H-Index: 16
view all 12 authors...
Abstract Accurate and reliable whole-brain segmentation is critical to longitudinal neuroimaging studies. We undertake a comparative analysis of two subcortical segmentation methods, Automatic Segmentation (ASEG) and Sequence Adaptive Multimodal Segmentation (SAMSEG), recently provided in the open-source neuroimaging package FreeSurfer 7.1, with regard to reliability, bias, sensitivity to detect longitudinal change, and diagnostic sensitivity to Alzheimer's disease. First, we assess intra- and i...
#1Anders M. Fjell (University of Oslo)H-Index: 76
#2Håkon Grydeland (University of Oslo)H-Index: 28
Last. Asta HåbergH-Index: 43
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Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 lo...
#1Øystein SørensenH-Index: 9
#2Anders M. FjellH-Index: 76
Last. Kristine B. WalhovdH-Index: 75
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We present generalized additive latent and mixed models (GALAMMs) for analysis of clustered data with latent and observed variables depending smoothly on observed variables. A profile likelihood algorithm is proposed, and we derive asymptotic standard errors of both smooth and parametric terms. The work was motivated by applications in cognitive neuroscience, and we show how GALAMMs can successfully model the complex lifespan trajectory of latent episodic memory, along with a discrepant trajecto...
#1Lars NybergH-Index: 105
#2Fredrik Magnussen (University of Oslo)H-Index: 3
Last. Anders M. Fjell (University of Oslo)H-Index: 76
view all 24 authors...
Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Ou...
1 CitationsSource
#1René Westerhausen (University of Oslo)H-Index: 39
#2Anders M. Fjell (University of Oslo)H-Index: 76
Last. William D. Hopkins (University of Texas MD Anderson Cancer Center)H-Index: 89
view all 7 authors...
The human corpus callosum exhibits substantial atrophy in old age, which is stronger than what would be predicted from parallel changes in overall brain anatomy. To date, however, it has not been conclusively established whether this accentuated decline represents a common feature of brain aging across species, or whether it is a specific characteristic of the aging human brain. In the present cross-sectional study, we address this question by comparing age-related difference in corpus callosum ...
2 CitationsSource
#1J. BinnewiesH-Index: 1
#2Laura NawijnH-Index: 18
Last. Brenda W.J.H. PenninxH-Index: 182
view all 5 authors...
#1Håkon Grydeland (University of Oslo)H-Index: 28
#2Donatas Sederevicius (University of Oslo)H-Index: 7
Last. Anders M. Fjell (University of Oslo)H-Index: 76
view all 16 authors...
STUDY OBJECTIVES A critical role linking sleep with memory decay and β-amyloid (Aβ) accumulation, two markers of Alzheimer's disease (AD) pathology, may be played by hippocampal integrity. We tested the hypotheses that worse self-reported sleep relates to decline in memory and intra-hippocampal microstructure, including in the presence of Aβ. METHODS Two-hundred and forty-three cognitively healthy participants, aged 19-81 years, completed the Pittsburgh Sleep Quality Index once, and 2 diffusion ...
#1Anders M. FjellH-Index: 76
#2Øystein SørensenH-Index: 9
Last. Kristine B. WalhovdH-Index: 75
view all 32 authors...
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and...
#1Bråthen Acs. (University of Oslo)H-Index: 1
#1Anne Cecilie Sjøli Bråthen (University of Oslo)H-Index: 6
Last. Kristine B. Walhovd (University of Oslo)H-Index: 75
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Risk and protective factors for cognitive function in aging may affect how much individuals benefit from their environment or life experiences by preserving or improving cognitive abilities. We inv...
1 CitationsSource
#1Lia Ferschmann (University of Oslo)H-Index: 6
#2Nandita Vijayakumar (Deakin University)H-Index: 21
Last. Christian K. Tamnes (University of Oslo)H-Index: 42
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Abstract Emotional disorders commonly emerge in adolescence, a period characterized by changes in emotion-related processes. Thus, the ability to regulate emotions is crucial for well-being and adaptive social functioning during this period. Concurrently, the brain undergoes large structural and functional changes. We investigated relations between tendencies to use two emotion regulation strategies, cognitive reappraisal and expressive suppression, and structural development of the cerebral cor...