Zena Werb
University of California, San Francisco
Matrix metalloproteinaseCancerInternal medicineEndocrinologyPathologyMolecular biologyStromal cellChemistryExtracellular matrixImmunologyMammary glandMetastasisAngiogenesisMorphogenesisCancer researchBreast cancerBiochemistryMedicineBiologyCell biology
549Publications
179H-index
109kCitations
Publications 528
Newest
#1Payam Shahi (UCSF: University of California, San Francisco)H-Index: 12
#2Chih Yang Wang (UCSF: University of California, San Francisco)H-Index: 16
Last. Zena Werb (UCSF: University of California, San Francisco)H-Index: 179
view all 9 authors...
Effect of elevated Zpo2 levels on Zpo1-, GATA3-, and EMT-associated genes. (A) qRT-PCR analysis indicating GATA3 levels in EpH4.9 cells overexpressing Zpo1 and Zpo2. (B) qRT-PCR analysis indicating that shRNA-mediated down-regulation of Zpo2 increases Gata3 levels. (C) Western blot analysis in EpH4.9 mammary epithelial cell extracts. Zpo2 overexpression lowers GATA3 levels. Zpo1 overexpression does not alter GATA3 levels. Down-regulation of Zpo2 elevates GATA3 levels. (D) qRT-PCR analysis of Gat...
12 CitationsSource
#1Daniel L Cooke (UCSF: University of California, San Francisco)H-Index: 17
#2Van V. Halbach (UCSF: University of California, San Francisco)H-Index: 86
Last. Zhengda Sun (UCSF: University of California, San Francisco)H-Index: 9
view all 14 authors...
Introduction: Cerebral aneurysms affect 1-6% of the population and their rupture carries significant mortality and morbidity. The paucity of data related to histopathological features of aneurysms stems largely from the risks associated with aneurysm tissue collection. We set out to establish a feasible technique to isolate viable endothelial cells (EC) and to characterize the differences in genetic expression (GE) between iliac arterial cells vs. aneurysm cells and non-ruptured vs. ruptured ane...
#1Chih Yang Wang (UCSF: University of California, San Francisco)H-Index: 16
#2Payam Shahi (UCSF: University of California, San Francisco)H-Index: 12
Last. Zena Werb (UCSF: University of California, San Francisco)H-Index: 179
view all 8 authors...
Author(s): Wang, CY; Shahi, P; Huang, JTW; Phan, NN; Sun, Z; Lin, YC; Lai, MD; Werb, Z | Abstract: i?½ 2017, Spandidos Publications. All rights reserved. The achaete-scute complex-like (ASCL) family, also referred to as ‘achaete-scute complex homolog’ or ‘achaete-scute family basic helix-loop-helix transcription factor’, is critical for proper development of the nervous system and deregulation of ASCL plays a key role in psychiatric and neurological disorders. The ASCL family consists of five me...
8 CitationsSource
#1Claire-Sophie Devignes (University of Paris)H-Index: 3
#2Audrey Brenot (UCSF: University of California, San Francisco)H-Index: 16
Last. Sylvain Provot (University of Paris)H-Index: 16
view all 10 authors...
Source
#1Dai HoriuchiH-Index: 13
#2Roman Camarda (UCSF: University of California, San Francisco)H-Index: 9
Last. Andrei Goga (UCSF: University of California, San Francisco)H-Index: 43
view all 20 authors...
In triple-negative breast cancer, the PIM1 kinase is highly expressed, acts to promote tumor cell survival and growth, and increases MYC transcriptional activity.
86 CitationsSource
#1Ken Takai (UCSF: University of California, San Francisco)H-Index: 12
#2Annie Le (St. George's University)H-Index: 2
Last. Zena Werb (UCSF: University of California, San Francisco)H-Index: 179
view all 4 authors...
// Ken Takai 1, 3 , Annie Le 1, 4 , Valerie M. Weaver 2 , Zena Werb 1 1 Department of Anatomy, University of California, San Francisco, CA, USA 2 Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, CA, USA 3 Present address: Division of Breast Oncology, Saitama Cancer Center, Saitama, Japan 4 Present address: St. George’s University School of Medicine, Grenada Correspondence to: Zena Werb, email: zena.werb@ucsf.edu Keywords: pirfe...
69 CitationsSource
#1Roni Allaoui (Lund University)H-Index: 6
#2Caroline Bergenfelz (Lund University)H-Index: 12
Last. Karin LeanderssonH-Index: 24
view all 15 authors...
A reactive tumour stroma is associated with poor prognosis. Here, the authors show that in patients with triple negative breast cancer resident monocytes activate cancer-associated fibroblasts and induce production of CXCL16, which acts as a monocyte chemoattractant, resulting in an amplificatory feedback loop.
60 CitationsSource
#1Alpa Trivedi (UCSF: University of California, San Francisco)H-Index: 14
#2Haoqian Zhang (UCSF: University of California, San Francisco)H-Index: 10
Last. Linda J. Noble-Haeusslein (UCSF: University of California, San Francisco)H-Index: 38
view all 7 authors...
Abstract Angiogenesis plays a critical role in wound healing after spinal cord injury. Therefore, understanding the events that regulate angiogenesis has considerable relevance from a therapeutic standpoint. We evaluated the contribution of matrix metalloproteinase (MMP)-2 to angiogenesis and vascular stability in spinal cord injured MMP-2 knockout and wildtype (WT) littermates. While MMP-2 deficiency resulted in reduced endothelial cell division within the lesioned epicenter, there were no geno...
9 CitationsSource
#1Zuzana Koledova (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 11
#2Xiaohong Zhang (Wellcome Trust Centre for Cell-Matrix Research)H-Index: 4
Last. Pengfei Lu (ShanghaiTech University)H-Index: 13
view all 7 authors...
The role of the local microenvironment in influencing cell behavior is central to both normal development and cancer formation. Here, we show that sprouty 1 (SPRY1) modulates the microenvironment to enable proper mammary branching morphogenesis. This process occurs through negative regulation of epidermal growth factor receptor (EGFR) signaling in mammary stroma. Loss of SPRY1 resulted in up-regulation of EGFR-extracellular signal-regulated kinase (ERK) signaling in response to amphiregulin and ...
26 CitationsSource
#1Lining Cao (UCSF: University of California, San Francisco)
#2Zhenjie Xu (Stanford University)
Last. Zena Werb (UCSF: University of California, San Francisco)H-Index: 179
view all 9 authors...