Mariana de Almeida
Universidade Estadual de Maringá
PharmacokineticsNuclear chemistryAbsorption (skin)NanoparticleOrganic chemistryAqueous solutionChemistryMyeloperoxidaseIn vivoCurcuminoidCurcuminCarnauba waxPolyvinylpyrrolidoneEdemaPaw edemaDifferential scanning calorimetryNitric oxide
Publications 2
#2Cristhian Rafael Lopes Francisco (UTFPR: Federal University of Technology - Paraná)H-Index: 7
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Abstract The pharmacokinetic of curcumin has posed a challenge to its therapeutic efficacy. Drug encapsulation systems, particularly microparticles, are promising due to their ability to protect compounds against both physical and chemical degradation and to improve their bioactivity. The aim of the present study was to prepare curcumin loaded solid lipid microparticles from carnauba wax and evaluate its antiinflammatory efficacy. Microparticles were obtained by hot homogenization technique and ...
Curcumin is the main curcuminoid found in turmeric rhizomes and is a strong candidate to formulate foodstuff with specific properties. Among various bioactive properties of curcumin, its antiinflammatory activity is remarkable; on the other hand, its low water solubility leads to low absorption. Thus, new formulations need to be developed to improve its efficacy, and encapsulation is a promising alternative strategy in this regard. The objective of the present study was to obtain curcumin-loaded...
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