Fatima Crispi
University of Barcelona
Citrate synthaseInternal medicineObstetricsEndocrinologySurgeryUltrasoundLikelihood ratios in diagnostic testingLogistic regressionParity (mathematics)Odds ratioCardiologyAndrologyReceptorFetusChemistryProspective cohort studyBeta-2 microglobulinHemopexinPlacental insufficiencyPlacentaFatty acid metabolismFetal echocardiographyPreeclampsiaFetal diseaseGestational hypertensionEvans BlueFluoresceinDyslipidemiaAnimal modelCholesterolLipid profileGestational ageIntrauterine growth restrictionHemoglobinSoluble fms-like tyrosine kinase-1PregnancyLipoproteinSpecific riskHypertension in PregnancyLipid peroxidationCord bloodSmall for gestational ageLesionEclampsiaMitochondrionPopulationNeurogenic Locus Notch Homolog Protein 1Fetal growthUltrasound guidedMitochondrial respiratory chainAnesthesiaPhysiologyIncidence (epidemiology)ProteomicsGestationLipid metabolismProportional hazards modelObesityDiabetes mellitusLipidomicsBirth weightQuartileMedicineComplicationVery low-density lipoproteinBiology
16Publications
5H-index
71Citations
Publications 16
Newest
#1Rebeca Santano (University of Barcelona)H-Index: 9
#2Diana Barrios (University of Barcelona)H-Index: 12
Last. Carlota Dobaño (University of Barcelona)H-Index: 34
view all 10 authors...
AO_SCPLOWBSTRACTC_SCPLOWSerological diagnostic of the severe respiratory distress syndrome coronavirus 2 (SARS-CoV-2) is a valuable tool for the determination of immunity and surveillance of exposure to the virus. In the context of an ongoing pandemic, it is essential to externally validate widely used tests to assure correct diagnostics and epidemiological estimations. We evaluated the performance of the COVID-19 ELISA IgG and IgM/A (Vircell, S.L.) against a highly specific and sensitive in-hou...
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OBJECTIVE To assess in women with early-onset severe preeclampsia whether longitudinal changes in angiogenic factors improve the prediction of adverse outcome. DESIGN Prospective cohort study. SETTING Maternity units in two Spanish hospitals. POPULATION Women with diagnosis of early-onset severe preeclampsia. METHODS Levels of placental growth factor [PlGF], soluble fms-like tyrosine kinase [sFlt-1] and sFlt-1/PlGF ratio were measured at admission and before delivery; and average daily change wa...
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#1Cristina Paules (University of Barcelona)H-Index: 8
#2Lina Youssef (University of Barcelona)H-Index: 4
Last. Eduard Gratacós (University of Barcelona)H-Index: 88
view all 8 authors...
Fetal growth restriction defined as the failure to achieve the fetal genetic growth potential is a major cause of perinatal morbidity and mortality. The role of maternal adaptations to placental insufficiency in this disorder is still not fully understood. We aimed to investigate the biological processes and protein-protein interactions involved in late-onset fetal growth restriction in particular. We applied 2D nano LC-MS/MS proteomics analysis on maternal blood samples collected at the time of...
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#1L. Youssef (Lund University)H-Index: 1
#2Lena Erlandsson (Lund University)H-Index: 13
Last. Stefan R. Hansson (Lund University)H-Index: 39
view all 9 authors...
Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n =...
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#1Lina Youssef (University of Barcelona)H-Index: 4
#2Fatima Crispi (University of Barcelona)H-Index: 5
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#1Lina Youssef (University of Barcelona)H-Index: 4
#2Jezid Miranda (University of Barcelona)H-Index: 20
Last. Fatima Crispi (University of Barcelona)H-Index: 5
view all 11 authors...
Abstract Background Preeclampsia and fetal growth restriction share some pathophysiological features and are both associated with placental insufficiency. Fetal cardiac remodeling has extensively been described in fetal growth restriction, whereas little is known about preeclampsia with a normally grown fetus. Objective To describe fetal cardiac structure and function in pregnancies complicated by preeclampsia and/or fetal growth restriction as compared to uncomplicated pregnancies. Study design...
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#1Cristina Paules (University of Barcelona)H-Index: 8
#2Lina Youssef (University of Barcelona)H-Index: 4
Last. E. Gratacós (University of Barcelona)H-Index: 21
view all 11 authors...
OBJECTIVES: To describe placental histopathological findings in a large cohort of pregnancies complicated by pre-eclampsia (PE) and/or small-for-gestational age (SGA), and to investigate their association with fetoplacental Doppler parameters. METHODS: This was a prospective observational study of normotensive pregnancies with SGA (defined as birth weight 95th centile or MCA-PI or CPR was < 5th centile. Placental lesions were categorized as vascular (maternal or fetal side), immunoinflammatory o...
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#1Mariona Guitart-Mampel (University of Barcelona)H-Index: 9
#2Diana Luz Juárez-Flores (University of Barcelona)H-Index: 7
Last. Glòria Garrabou (University of Barcelona)H-Index: 20
view all 15 authors...
: Intrauterine growth restriction (IUGR) is an obstetric complication characterised by placental insufficiency and secondary cardiovascular remodelling that can lead to cardiomyopathy in adulthood. Despite its aetiology and potential therapeutics are poorly understood, bioenergetic deficits have been demonstrated in adverse foetal and cardiac development. We aimed to evaluate the role of mitochondria in human pregnancies with IUGR. In a single-site, cross-sectional and observational study, we in...
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#1Jezid Miranda (University of Barcelona)H-Index: 20
#2Rui V. Simões (University of Barcelona)H-Index: 15
Last. Eduard Gratacós (University of Barcelona)H-Index: 88
view all 17 authors...
Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and ...
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#1J.U. OrtizH-Index: 1
Last. Fatima CrispiH-Index: 5
view all 7 authors...
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