Sheila M. Grecian
University of Edinburgh
OffspringOphthalmologyInternal medicineLogistic regressionOdds ratioFetusTortuosityPediatricsProspective cohort studySystemic inflammationLiver diseaseType 2 diabetesCirrhosisHyaluronic acidHepatocellular carcinomaRetinopathyHospital Anxiety and Depression ScaleFatty liverThyroid nodulesLow birth weightDepression (differential diagnoses)DiseaseHypothalamic–pituitary–adrenal axisDementiaDiabetic retinopathyRetinalGlucocorticoidLiver fibrosis scoreCognitive declineGeneral hospitalCortisol secretionPhysiologyIncidence (epidemiology)Risk factorThyroidMedicineCohortGastroenterology
Publications 6
#1Sheila M. Grecian (Edin.: University of Edinburgh)H-Index: 2
#2Stela McLachlan (Edin.: University of Edinburgh)H-Index: 25
Last. Mark W. J. Strachan (Western General Hospital)H-Index: 46
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#1Alistair L. Carr (Edin.: University of Edinburgh)
#2Anniek J. Sluiman (Edin.: University of Edinburgh)H-Index: 1
Last. Jackie F. Price (Edin.: University of Edinburgh)H-Index: 4
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Aims/hypothesis We aimed to determine the association of depression with dementia risk in people with type 2 diabetes, and to explore the possible mediating role of inflammation in this relationship. Methods The Edinburgh Type 2 Diabetes Study is a prospective cohort of 1066 men and women with type 2 diabetes aged 60-75 years. Cox proportional hazards regression analysis was used to investigate the association between depression, assessed at baseline, and subsequent risk of dementia over 10 year...
#1Rachel Forster (Edin.: University of Edinburgh)H-Index: 8
#2Emmanuel Sandoval Garcia (Edin.: University of Edinburgh)H-Index: 1
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AIMS/HYPOTHESIS Our aim was to determine whether a range of prespecified retinal vessel traits were associated with incident diabetic retinopathy in adults with type 2 diabetes. METHODS In the prospective observational cohort Edinburgh Type 2 Diabetes Study of 1066 adults with type 2 diabetes, aged 60-75 years at recruitment, 718 were free from diabetic retinopathy at baseline. Baseline retinal traits including vessel widths, tortuosity (curvature) and fractal dimensions (network complexity), we...
1 CitationsSource
#1Sheila M. Grecian (Edin.: University of Edinburgh)H-Index: 2
#2Stela McLachlan (Edin.: University of Edinburgh)H-Index: 14
Last. Mark W. J. Strachan (Western General Hospital)H-Index: 46
view all 14 authors...
BACKGROUND The incidence of cirrhosis and hepatocellular carcinoma (HCC) is increased in Type 2 diabetes, primarily secondary to non-alcoholic fatty liver disease (NAFLD). European guidelines recommend screening for NAFLD in Type 2 diabetes. American guidelines, while not advocating a screening protocol, suggest using non-invasive markers of fibrosis for risk-stratification and guiding onward referral. AIMS To test the ability of individual fibrosis scores and the European screening algorithm to...
2 CitationsSource
#1Sheila M. GrecianH-Index: 2
Last. Rachel M. WilliamsonH-Index: 11
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#1Thomas C. Carpenter (Edin.: University of Edinburgh)H-Index: 2
#2Sheila M. Grecian (Edin.: University of Edinburgh)H-Index: 2
Last. Rebecca M. Reynolds (Edin.: University of Edinburgh)H-Index: 64
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: Fetal glucocorticoid overexposure is a key mechanism linking early development with later-life disease. In humans, low birth weight associates with increased fasting cortisol, hypothalamic-pituitary-adrenal (HPA) axis reactivity, and with cardiovascular risk and cognitive decline. As there are sex differences in these adult diseases, we hypothesized that there may be sex differences in programming of the HPA axis in response to prenatal stressors. We conducted a systematic review following Met...
86 CitationsSource