Yeran Bai
Boston University
Chemical specificitySignalTemporal resolutionPhase (waves)OpticsMicroscopyInfraredInterferometryUltrashort pulsePhotothermal therapyScatteringMaterials scienceImage resolutionPhotothermal effectCharacterization (materials science)OptoelectronicsLaserWavelengthChemical imagingMicroscopeResolution (electron density)
17Publications
5H-index
124Citations
Publications 15
Newest
#1Jiaze YinH-Index: 2
#2Lu LanH-Index: 14
Last. Ji-Xin ChengH-Index: 84
view all 8 authors...
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#5M. Selim Ünlü (BU: Boston University)H-Index: 27
Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal the specimen's size and shape information, the chemical composition is inaccessible in interferometric measurements. Infrared spectroscopic imaging provides chemical specificity based on inherent chemical bond vibrations of specimens but lacks the ability to i...
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#1Yeran Bai (BU: Boston University)H-Index: 5
#2Jiaze Yin (BU: Boston University)H-Index: 2
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 3 authors...
Mid-infrared (IR) spectroscopic imaging using inherent vibrational contrast has been broadly used as a powerful analytical tool for sample identification and characterization. However, the low spatial resolution and large water absorption associated with the long IR wavelengths hinder its applications to study subcellular features in living systems. Recently developed mid-infrared photothermal (MIP) microscopy overcomes these limitations by probing the IR absorption-induced photothermal effect u...
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#4Meng Zhang (BU: Boston University)H-Index: 15
#5M. Selim Ünlü (BU: Boston University)H-Index: 27
Mid-infrared photothermal (MIP) microscopy has been a promising label-free chemical imaging technique for functional characterization of specimens owing to its enhanced spatial resolution and high specificity. Recently developed wide-field MIP imaging modalities have drastically improved speed and enabled high-throughput imaging of micron-scale subjects. However, the weakly scattered signal from sub-wavelength particles becomes indistinguishable from the shot-noise as a consequence of the strong...
#4Meng Zhang (BU: Boston University)H-Index: 15
Mid-infrared photothermal microscopy (MIP) has been a promising chemical imaging technique for functionality characterization of biological and pharmaceutical specimens owing to its enhanced resolution and high-specificity. Recently developed wide-field MIP modalities drastically improved the imaging speed and thus enabled high-throughput imaging. However, the sensitivity of the wide-field MIP technique has been limited by shot-noise of background photons. Here, we demonstrate a dark-field MIP m...
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#1Yeran Bai (BU: Boston University)H-Index: 5
#3Ji-Xin Cheng (BU: Boston University)H-Index: 84
We developed a versatile mid-infrared photothermal (MIP) modality that enabled study of metabolic activities in living cells coupled with stable isotope probing. Performance of laser and light emitting diode were compared and system detection limit was demonstrated for different stable isotope probes. We treated the cancer and bacteria cells with deuterium, 13C and 15N labelled nutrients, and acquired the multi-spectral images with the MIP microscope. We observed the red shift in the infrared sp...
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#1Jiaze Yin (BU: Boston University)H-Index: 2
#2Lu Lan (BU: Boston University)H-Index: 14
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 6 authors...
Mid-infrared photothermal (MIP) microscopy overcomes the resolution and huge water background limits in conventional mid-infrared imaging by probing the mid-infrared absorption induced photothermal effect. However, to detect the subtle MIP signal, large probe power and lock-in detection are needed, which limit the imaging speed of current MIP systems. To overcome this limitation, we develop a single-pixel pump-probe camera that leverages the large well-depth capacity of photodiode to achieve hig...
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#1Cheng Zong (BU: Boston University)H-Index: 19
#2Chi Zhang (BU: Boston University)H-Index: 22
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 8 authors...
Traditional electrochemical measurements based on either current or potential responses only present the average contribution of an entire electrode's surface. Here, we present an electrochemical photothermal reflectance microscope (EPRM) in which a potential-dependent nonlinear photothermal signal is exploited to map an electrochemical process with sub-micron spatial resolution. By using EPRM, we are able to monitor the photothermal signal of a Pt electrode during the electrochemical reaction a...
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#2Haonan Zong (BU: Boston University)H-Index: 2
Last. Ji-Xin ChengH-Index: 84
view all 5 authors...
Chemical characterization of biological specimens in the mid-infrared (IR) window plays a central role in the analysis of their functionalities. Although recent advances in mid-IR microscopy have demonstrated detection of the sample’s chemical contrast at a sub-micron resolution using a visible probe beam, they have limited sensitivity at high-throughput. To overcome this limit, we employ wide-field interferometric microscopy to detect the minute change in the optical path induced by mid-IR abso...
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#1Delong Zhang (ZJU: Zhejiang University)H-Index: 22
#2Lu Lan (BU: Boston University)H-Index: 14
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 84
view all 7 authors...
Phase-contrast microscopy converts the phase shift of light passing through a transparent specimen, e.g., a biological cell, into brightness variations in an image. This ability to observe structures without destructive fixation or staining has been widely utilized for applications in materials and life sciences. Despite these advantages, phase-contrast microscopy lacks the ability to reveal molecular information. To address this gap, we developed a bond-selective transient phase (BSTP) imaging ...
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