Ye-Ting Zou
Nanjing University of Chinese Medicine
Dissociation (chemistry)AnalyteGlycomicsMetabolomeIonGlycomeMass spectrometryChemical structureOrganic chemistryChemistryMetabolic pathwayElectrosprayMetabolomicsAdrenal fatigueDysbiosisIleumMetabolitePathogenic bacteriaGinsengXanthineTriterpeneLinoleic acidSpleenHypoxanthineMoutan cortexRehmanniae RadixIridoid GlycosidesTransplantationSoftware toolMass spectrometricUplc qtof msUplc esi qtof msSulfur containingUntargeted metabolomicsMetabolomics dataMultivariate statisticalTandem mass spectrometryQuadrupoleChromatographySulfurGut floraComputational biologySelected reaction monitoringLinearityPharmacology
6Publications
3H-index
35Citations
Publications 6
Newest
#1Ye-Ting Zou (Nanjing University of Chinese Medicine)H-Index: 3
#2Jing Zhou (Nanjing University of Chinese Medicine)H-Index: 8
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 5
view all 9 authors...
Abstract Ethnopharmacological relevance Poria cocos (Schw.) Wolf (Poria) is a well-known traditional medicinal fungus. It has been considered to possess spleen-invigorating (Jianpi) effects in traditional Chinese medicine, and is used clinically to treat spleen deficiency (Pixu) with symptoms of intestinal disorders such as diarrhea, indigestion, mucositis and weight loss. The aim of this study To investigate the protective effects of Poria and its three component fractions (Water-soluble polysa...
1 CitationsSource
#1Ye-Ting Zou (Nanjing University of Chinese Medicine)H-Index: 3
#2Fang Long (Nanjing University of Chinese Medicine)H-Index: 3
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 8 authors...
INTRODUCTION: Triterpene acids from the dried sclerotia of Poria cocos (Schw.) Wolf (poria) were recently found to possess anti-cancer activities. Identification of more triterpene acid analogues in poria is worthwhile for high throughput screening in anti-cancer drug discovery. OBJECTIVE: To establish an efficient dereplication strategy for identifying triterpene acid analogues in poria based on ultra-performance liquid chromatography with electrospray ionisation quadrupole time-of-flight tande...
1 CitationsSource
#1Li Zhou (Nanjing University of Chinese Medicine)H-Index: 4
#2Jin-Di Xu (Hong Kong Baptist University)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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Abstract In metabolomics studies, metabolic pathway recognition (MPR) is performed by software tools to screen out the significant pathways disturbed by diseases or reinstated by drugs. To achieve MPR, the significantly changed metabolites determined in different biospecimens ( e.g. plasma and urine) are analyzed either independently (metabolites from each biospecimen as a dataset) or integratively (metabolites from all biospecimens as a dataset). However, whether the choice of these two process...
2 CitationsSource
#1Xiu-Yang Li (Nanjing University of Chinese Medicine)H-Index: 6
#2Jin-Di Xu (Nanjing University of Chinese Medicine)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 11 authors...
Abstract In this study, a time segment scanning-based quasi -multiple reaction monitoring ( quasi -MRM) mode was proposed to improve the quantitative performance of UPLC-QTOF-MS/MS. To achieve the quasi -MRM mode, a strategy to select the ion pair (precursor and product ions) of each analyte was adopted as follows. First, a stable and abundant ion by quadrupole was set as precursor ion in MS scan mode. Second, the fragment ions of the precursor ion formed via collision-induced dissociation were ...
4 CitationsSource
#1Li Zhang (Nanjing University of Chinese Medicine)H-Index: 22
#2Hong Shen (Nanjing University of Chinese Medicine)H-Index: 14
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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Abstract In this study, a novel ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-QTOF-MS/MS)-guidance strategy was proposed for preparation of sulfur-containing derivatives in sulfur-fumigated edible herbs. Being versatile in both chromatographic separation and mass spectrometric detection, UPLC-QTOF-MS/MS was inducted into each experimental step for multifaceted purposes including finding, tracking, purity determination and structural elucid...
11 CitationsSource
#1Li Zhou (Nanjing University of Chinese Medicine)H-Index: 4
#2Jin-Di Xu (Nanjing University of Chinese Medicine)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 10 authors...
Abstract Exploring processing chemistry, in particular the chemical transformation mechanisms involved, is a key step to elucidate the scientific basis in traditional processing of herbal medicines. Previously, taking Rehmanniae Radix (RR) as a case study, the holistic chemome (secondary metabolome and glycome) difference between raw and processed RR was revealed by integrating hyphenated chromatographic techniques-based targeted glycomics and untargeted metabolomics. Nevertheless, the complex c...
14 CitationsSource