M. S. Lar’kina
Tomsk Polytechnic University
Systematic errorQuality assuranceNISTAnalytical chemistryDetection limitGas chromatographyElectron capture detectorHorticultureIonRepeatabilityRadionuclideIsotopeRadiochemistryOrganic chemistryNucleophileHigh-performance liquid chromatographyChemical modificationChemistryChelationIn vitroGlutamate carboxypeptidase IIGas chromatography–mass spectrometryIn vivoCombinatorial chemistryPositron emission tomographyRutinChlorobenzeneSomatostatinHER2/neuDARPinHeptaneAntioxidantCentaureaSulfur hexafluorideFlavonoidNeuroendocrine tumorsMedicinal plantsDerivative (chemistry)AsteraceaeProstate cancerCyclohexanoneSolventFluorideOctreotideAdenocarcinomaCentaurea scabiosaIntralaboratoryNuclear medicineRadionuclide imagingPlant compositionAbove groundQuantitative determinationTumor growthDiagnostic methodsModified methodHer 2 neuPharmacology toxicologyAnalytical hplcHigh effectivenessMoleculeMass spectrumChromatographyCancer researchYield (chemistry)BotanyMedicineRandom errorPhotochemistryCell cultureBiologyQuantitative analysis (chemistry)Phosphate buffered saline
14Publications
3H-index
42Citations
Publications 13
Newest
#1M. S. Lar’kina (Tomsk Polytechnic University)H-Index: 3
Last. Mekhman S. YusubovH-Index: 19
view all 7 authors...
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#1O. Bragina (Research Medical Center)H-Index: 2
#2Anzhelika Vorobyeva (Uppsala University)H-Index: 11
Last. R. Zel'chan (Research Medical Center)H-Index: 2
view all 11 authors...
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#1M. S. Lar’kina (Siberian State Medical University)H-Index: 3
#2S. V. Krivoshchekov (Tomsk Polytechnic University)H-Index: 3
Last. Mekhman S. Yusubov (Tomsk Polytechnic University)H-Index: 15
view all 9 authors...
Preclinical studies of a new octreotide derivative with a chelate (DPAH-octreotide) that binds 99mTc for radiological diagnosis of neuroendocrine tumors are currently in progress. A method for preparing DPAH-octreotide is based on forming an amide bond between the amine of D-phenylalanine and the bifunctional chelate succinimid-1-yl 6-[bis(pyridin-2-ylmethyl)amino]hexanoate. An HPLC method for determining the identity, impurities, and quantitative content is proposed for DPAH-octreotide quality ...
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#2M. S. Lar’kina (Siberian State Medical University)H-Index: 3
Last. S. V. Krivoshchekov (Siberian State Medical University)H-Index: 2
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A GC method for quantitative determination of cyclohexanone by oxidative cleavage was proposed. The research was aimed at the development of a simple, rapid, and effective GC method for quantitative analysis of cyclohexanone in a reaction mixture. Chlorobenzene was used as an internal standard. Qualitative analysis compared mass spectra obtained for each component with mass spectra from the National Institute of Standards and Technology (NIST) database. The method was validated for specificity, ...
Source
#2Anzhelika VorobyevaH-Index: 11
#3V. M. TolmachevH-Index: 1
Last. A.A. MedvedevaH-Index: 1
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#3M. S. Lar’kinaH-Index: 3
#5I.G. SinilkinH-Index: 4
Last. A.A. MedvedevaH-Index: 1
view all 6 authors...
Source
#1M. S. Lar’kinaH-Index: 3
Last. Sergey M. DeyevH-Index: 29
view all 10 authors...
The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodo-aliphatic carboxylic acids and their esters ...
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#1O.D. BraginaH-Index: 4
#2M. S. Lar’kinaH-Index: 3
Last. M. BuldakovH-Index: 1
view all 11 authors...
It is still necessary to search for new informative diagnostic methods to detect malignant tumors with overexpression of Her-2/neu, which are characterized by the aggressive course of the disease, rapid rate of tumor growth and low rates of relapse-free and overall survival. In recent years, the radioisotope techniques for detection of specific tumor targets have been developing actively. Purpose: to develop a chemically stable radiochemical compound for the targeted imaging of cells overexpress...
Source
#1S. V. Krivoshchekov (Tomsk Polytechnic University)H-Index: 3
#2M. S. Lar’kinaH-Index: 3
Last. Mekhman S. Yusubov (Tomsk Polytechnic University)H-Index: 19
view all 7 authors...
Amethod for assaying sulfur hexafluoride in a new contrast agent by gas chromatography is described. Detection was with an electron capture detector (ECD). Sulfur hexafluoride was extracted from samples using heptane as the solvent. The method was validated in terms of the following parameters: specificity, linearity, correctness, stability, and inter- and intralaboratory precision.
Source
#1ЧерновH-Index: 1
#2V. I. ChernovH-Index: 5
Last. V. S. SkuridinH-Index: 6
view all 18 authors...
Source
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