Xiao-Ling Shen
Guangzhou University of Chinese Medicine
CytotoxicityAmorphous metalEndocrinologyLipogenesisCytotoxic T cellChemistryMagnetic refrigerationAdipocyteHeLaInsulin resistanceCajanusHypericumFatty liverDiabetes mellitusTraditional medicineCell growthStereochemistryMedicineCell cultureBiology
20Publications
7H-index
117Citations
Publications 19
Newest
#1Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jia-Wen Huang (Guangzhou University of Chinese Medicine)
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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Abstract Background We had reported that cajanolactone A (CLA) from Cajanus cajan dose-dependently inhibited ovariectomy-induced obesity and liver steatosis in mice, showing potential to prevent postmenopausal obesity and fatty liver. In this study, the role of CLA in the regulation of energy and lipid homeostasis was investigated. Methods Ovariectomized mice treated with CLA or vehicle for 12 weeks were performed a 48 h monitoring for energy metabolism and food uptake. After that, hypothalami, ...
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#1Peng-Cheng Zhong (Guangzhou University of Chinese Medicine)
#2Rong Shu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Ying-Jie Hu (Guangzhou University of Chinese Medicine)H-Index: 6
view all 6 authors...
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#1Peng-Cheng Zhong (Guangzhou University of Chinese Medicine)
#2Rong Shu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Ying-Jie Hu (Guangzhou University of Chinese Medicine)H-Index: 6
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#1Xiao Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yi-Ying Lin (Guangzhou University of Chinese Medicine)
Last. Rui-Yi Yang (Guangzhou University of Chinese Medicine)H-Index: 1
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CONTEXT Lappaol F (LAF), a natural lignan from Arctium lappa Linne (Asteraceae), inhibits tumour cell growth by inducing cell cycle arrest. However, its underlying anticancer mechanism remains unclear. OBJECTIVE The effects of LAF on the Hippo-Yes-associated protein (YAP) signalling pathway, which plays an important role in cancer progression, were explored in this study. MATERIALS AND METHODS Cervical (HeLa), colorectal (SW480), breast (MDA-MB-231) and prostate (PC3) cancer cell lines were trea...
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#1Zhi-Wen Liu (Guangzhou University of Chinese Medicine)H-Index: 1
#2Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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Abstract Background Osteoporosis is a systemic skeletal disease that leads to a high risk for bone fractures. Morinda officinalis How. has been used as osteoporosis treatment in China. However, its mechanism of action as an anti-osteoporotic herb remains unknown. Methods A network pharmacology approach was applied to explore the potential mechanisms of action of M. officinalis in osteoporosis treatment. The active compounds of M. officinalis and their potential osteoporosis-related targets were ...
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#1Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
#2Zhi-Wen Liu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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ABSTRACT BACKGROUND : Visceral obesity and fatty liver are prevalent in postmenopausal women. The stilbene-rich extract of Cajanus cajan (L.) Millsp. has been reported to prevent ovariectomy-induced and diet-induced weight gain in animal models, and stilbenoids from C. cajan are thought to have the potential to prevent postmenopausal obesity and fatty liver. PURPOSE : Cajanolactone A (CLA) is the main stilbenoid from C. cajan with osteoblastogenic promoting activity. This study investigated the ...
1 CitationsSource
#1Zhao Qu (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yan Chen (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Ying-Jie Hu (Guangzhou University of Chinese Medicine)H-Index: 6
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OBJECTIVES: Neuroprotective potential of 7-methoxyflavanone (7MF) and its underlying mechanism was investigated. METHODS: Inhibitory effects of 7MF on microglial activation and neuroinflammation were evaluated by employment of lipopolysaccharide (LPS)-induced BV2 microglial cells. Changes in expression of genes and proteins of interest were investigated by RT-qPCR analysis and Western blot analysis. Inhibitory effects of 7MF on microglial overactivation were verified in LPS-treated C57BL/6J mice...
2 CitationsSource
#1Shan Liu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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Cajanolactone A (CLA) is a stilbenoid discovered by us from Cajanus cajan (L.) Millsp. In our study, CLA was found to promote osteoblast differentiation in human bone marrow mesenchymal stem cells (hBMSCs), as judged by increased cellular alkaline phosphatase activity and extracellular calcium deposits, and elevated protein expression of Runx2, collagen-1, bone morphogenetic protein-2, and osteopontin. Mechanistic studies revealed that hBMSCs undergoing osteoblast differentiation expressed upreg...
5 CitationsSource
#1Rui-Yi Yang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Lu Wang (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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: The present study investigated the effects of cajanonic acid A (CAA), extracted from the leaves of Cajanus cajan (L.) Millsp with a purity of 98.22%, on the regulatory mechanisms of glucose and lipid metabolism. HepG2 cells transfected with a protein‑tyrosine phosphatase 1B (PTP1B) overexpression plasmid were established. The cells, induced with insulin resistance by dexamethasone (Dex) treatment, together with type 2 diabetes mellitus (T2DM) model rats and ob/ob mice, were used in the present...
8 CitationsSource
#1Nenling Zhang (CAS: Chinese Academy of Sciences)H-Index: 5
#2Xiangchun ShenH-Index: 2
Last. Samuel X. Qiu (CAS: Chinese Academy of Sciences)H-Index: 4
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Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluate...
3 CitationsSource