Faisal Alsufyani
King Fahad Specialist Hospital
Molecular biologyCytotoxic T cellCD8ChemistryT-cell receptorMajor histocompatibility complexT cellBovine coronavirusRed pulpFollicular B cellMemory T cellB cellHemagglutinin (influenza)Marginal zoneSialic acidMarginal zone B-cellCytokinesisMedicineImmune systemCell biology
9Publications
2H-index
13Citations
Publications 8
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#2Faisal AlsufyaniH-Index: 2
Last. Shiv PillaiH-Index: 50
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Although fibrotic disorders are frequently assumed to be linked to TH2 cells, quantitative tissue interrogation studies have rarely been performed to establish this link and certainly many fibrotic diseases do not fall within the type 2/allergic disease spectrum. We have previously linked two human autoimmune fibrotic diseases, IgG4-related disease and systemic sclerosis, to the clonal expansion and lesional accumulation of CD4+CTLs. In both these diseases TH2 cell accumulation was found to be s...
1 CitationsSource
#1Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 50
#2Faisal Alsufyani (Ragon Institute of MGH, MIT and Harvard)H-Index: 2
The accumulation of B cells and tertiary lymphoid organs in metastatic melanoma patients receiving checkpoint blockade therapy was associated with long-term survival.
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#1Vinay S. Mahajan (Ragon Institute of MGH, MIT and Harvard)H-Index: 23
#2Ezana Demissie (Ragon Institute of MGH, MIT and Harvard)H-Index: 2
Last. Shiv PillaiH-Index: 50
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The control of cytoskeletal dynamics by dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified in patients with a recessive form of combined immunodeficiency with defects in T, B, and NK cell activation. Surprisingly, we show in this study that certain immune functions of CD8(+) T cells are enhanced in the absence of DOCK2. Dock2-deficient mice have a pr...
1 CitationsSource
#1Faisal Alsufyani (MIT: Massachusetts Institute of Technology)H-Index: 2
#2Shiv Pillai (MIT: Massachusetts Institute of Technology)H-Index: 50
T cells that target β-synuclein induce damage to the gray matter of the brain in multiple sclerosis and contribute to neurodegeneration.
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#1Ezana Demissie (Ragon Institute of MGH, MIT and Harvard)H-Index: 2
#2Vinay S. Mahajan (Ragon Institute of MGH, MIT and Harvard)H-Index: 23
Last. Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 50
view all 10 authors...
Abstract The control of cytoskeletal dynamics by Dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified in patients with a recessive form of combined immunodeficiency with defects in T, B and NK cell activation. Surprisingly, we show here that certain immune functions of CD8+ T cells are enhanced in the absence of DOCK2. Dock2-deficient mice have a prono...
1 CitationsSource
#1Vinay S. Mahajan (Brigham and Women's Hospital)H-Index: 23
#2Faisal Alsufyani (Ragon Institute of MGH, MIT and Harvard)H-Index: 2
Last. Shiv Pillai (Harvard University)H-Index: 50
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: We used Casd1-deficient mice to confirm that this enzyme is responsible for 9-O-acetylation of sialic acids in vivo. We observed a complete loss of 9-O-acetylation of sialic acid on the surface of myeloid, erythroid and CD4+ T cells in Casd1-deficient mice. Although 9-O-acetylation of sialic acids on multiple hematopoietic lineages was lost, there were no obvious defects in hematopoiesis. Interestingly, erythrocytes from Casd1-deficient mice also lost reactivity to TER-119, a rat monoclonal an...
4 CitationsSource
#1Faisal Alsufyani (Ragon Institute of MGH, MIT and Harvard)H-Index: 2
#2Hamid Mattoo (Ragon Institute of MGH, MIT and Harvard)H-Index: 21
Last. Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 50
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The Mst1 and 2 cytosolic serine/threonine protein kinases are the mammalian orthologs of the Drosophila Hippo protein. Mst1 has been shown previously to participate in T-cell and B-cell trafficking and the migration of lymphocytes into secondary lymphoid organs in a cell-intrinsic manner. We show here that the absence of Mst1 alone only modestly impacts B cell homing to lymph nodes. The absence of both Mst1 and 2 in hematopoietic cells results in relatively normal B cell development in the bone ...
6 CitationsSource
#1Faisal Alsufyani (Ragon Institute of MGH, MIT and Harvard)H-Index: 2
#2Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 50
A two-cell type CRISPR screen has identified genes and pathways that mediate resistance to cancer immunotherapy.
1 CitationsSource
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