Mark Owyong
University of California, San Francisco
GeneDyscrasiaCancerPhenotypeSoft tissuePathologyCellGene expressionCytotoxic T cellStromal cellNeuroscienceExtracellular matrixTissue microarrayAcquired immune systemMesenchymal stem cellIn vitroImmunologyMMP9Tumor microenvironmentSplenectomyMelanomaBrain metastasisAnemiaSarcomaTumor initiationMetastasisImmunosenescenceDiseaseTumor progressionSurgical oncologyPrimary tumorCancer immunotherapyLymph nodeDuctal carcinomaSpleenLesionTargeted therapyPopulationKaposiform HemangioendotheliomaChimeric antigen receptorCancer researchRadiation therapyBreast cancerCarcinogenesisCirculating tumor cellSignal transductionMedicineBiomarker (medicine)BiologyImmune systemCancer cell
8Publications
5H-index
78Citations
Publications 8
Newest
#1Aamna J. AbbasiH-Index: 1
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#1Catharina Hagerling (UCSF: University of California, San Francisco)H-Index: 8
#2Mark Owyong (UCSF: University of California, San Francisco)H-Index: 5
Last. Vicki Plaks (UCSF: University of California, San Francisco)H-Index: 20
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Novel biomarkers are required to discern between breast tumors that should be targeted for treatment from those that would never become clinically apparent and/or life threatening for patients. Moreover, therapeutics that specifically target breast cancer (BC) cells with tumor-initiating capacity to prevent recurrence are an unmet need. We investigated the clinical importance of LGR5 in BC and ductal carcinoma in situ (DCIS) to explore LGR5 as a biomarker and a therapeutic target. We stained BC ...
1 CitationsSource
#1Mark Owyong (UCSF: University of California, San Francisco)H-Index: 5
#2Jonathan Chou (UCSF: University of California, San Francisco)H-Index: 20
Last. Vicki Plaks (UCSF: University of California, San Francisco)H-Index: 20
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Metastasis, the main cause of cancer-related death, has traditionally been viewed as a late-occurring process during cancer progression. Using the MMTV-PyMT luminal B breast cancer model, we demonstrate that the lung metastatic niche is established early during tumorigenesis. We found that matrix metalloproteinase 9 (MMP9) is an important component of the metastatic niche early in tumorigenesis and promotes circulating tumor cells to colonize the lungs. Blocking active MMP9, using a monoclonal a...
6 CitationsSource
#1Mark Owyong (UCSF: University of California, San Francisco)H-Index: 5
#2Gizem Efe (UCSF: University of California, San Francisco)H-Index: 3
Last. Vicki Plaks (UCSF: University of California, San Francisco)H-Index: 20
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There is a growing list of cancer immunotherapeutics approved for use in a population with an increasing number of aged individuals. Cancer immunotherapy (CIT) mediates tumor destruction by activating anti-tumor immune responses that have been silenced through the oncogenic process. However, in an aging individual, immune deregulation is positively correlated with age. In this context, it is vital to examine the age-related changes in the tumor microenvironment (TME) and specifically, those dire...
12 CitationsSource
#1Zhengda Sun (UCSF: University of California, San Francisco)H-Index: 9
#2Chih Yang Wang (NCKU: National Cheng Kung University)H-Index: 16
Last. Daniel L Cooke (UCSF: University of California, San Francisco)H-Index: 17
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// Zhengda Sun 1, * , Chih-Yang Wang 2, 5, * , Devon A. Lawson 3 , Serena Kwek 4 , Hugo Gonzalez Velozo 2 , Mark Owyong 2 , Ming-Derg Lai 5 , Lawrence Fong 4 , Mark Wilson 1 , Hua Su 6 , Zena Werb 2 and Daniel L. Cooke 1 1 Division of Neurointerventional Radiology, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA 2 Department of Anatomy, University of California, San Francisco, CA 94143, USA 3 Department of Physiology and Biophysics, Universi...
21 CitationsSource
#1Mark Owyong (UCSF: University of California, San Francisco)H-Index: 5
#2Niloufar Hosseini-Nassab (Stanford University)H-Index: 7
Last. Bryan Ronain Smith (Stanford University)H-Index: 20
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The advent of cancer immunotherapy (CIT) and its success in treating primary and metastatic cancer may offer substantially improved outcomes for patients. Despite recent advancements, many malignancies remain resistant to CIT, among which are brain metastases, a particularly virulent disease with no apparent cure. The immunologically unique niche of the brain has prompted compelling new questions in immuno-oncology such as the effects of tissue-specific differences in immune response, heterogene...
11 CitationsSource
#1Hongwei Shao (UM: University of Miami)H-Index: 2
#2Long Cai (UM: University of Miami)H-Index: 2
Last. Zhao-Jun Liu (UM: University of Miami)H-Index: 23
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// Hongwei Shao 1, * , Long Cai 1, 2, * , Mecker Moller 1 , Biju Issac 3 , Leiming Zhang 1, 4 , Mark Owyong 1 , Anna Elizabeth Moscowitz 1 , Roberto Vazquez-Padron 1 , Freddy Radtke 5 , Zhao-Jun Liu 1, 3 1 Department of Surgery, University of Miami School of Medicine, Miami, USA 2 Hangzhou Red-Cross Hospital, Zhejiang, China 3 Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA 4 Yantai University, School of Pharmacy, Shandong, China 5 Ecole Polytechnique Federale de Lausa...
12 CitationsSource
#1Samuel A. Shabtaie (UM: University of Miami)H-Index: 3
#2Bo Wang (UM: University of Miami)H-Index: 5
Last. Anthony R. Hogan (UM: University of Miami)H-Index: 13
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Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor that usually manifests during early childhood. Typically the lesion presents with skin, soft tissue and bone involvement and is characterized histologically by ill-defined nodularity and the presence of spindle cells with resemblance to Kaposi's sarcoma. We report a rare neonatal case of a splenic kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon that was diagnosed with radiographic imaging. Bec...
3 CitationsSource