Wanting Niu
Brigham and Women's Hospital
Regeneration (biology)Platelet-derived growth factor receptorChemistryIn vivoGrowth factorAngiogenesisChondrocyteStem cellNeurogenesisTissue engineeringMedicineBiologyCell biology
14Publications
3H-index
31Citations
Publications 10
Newest
#1Wanting NiuH-Index: 3
#2Teck Chuan LimH-Index: 9
Last. Myron SpectorH-Index: 67
view all 7 authors...
Bone marrow mesenchymal stem cells (bMSCs) are responsible in the repair of injured tissue through differentiation into multiple cell types and secretion of paracrine factors, and thus have a broad application profile in tissue engineering/regenerative medicine, especially for the musculoskeletal system. The lesion due to injury or disease may be a closed irregular-shaped cavity deep within tissue necessitating an injectable biomaterial permissive of host (endogenous) cell migration, proliferati...
Source
#1Abdulmonem Alshihri (KSU: King Saud University)H-Index: 8
#2Wanting Niu (Brigham and Women's Hospital)H-Index: 3
Last. Myron Spector (Brigham and Women's Hospital)H-Index: 67
view all 7 authors...
The treatment of a variety of defects in bony sites could benefit from mitogenic stimulation of osteoprogenitor cells, including endogenous bone marrow-derived mesenchymal stem cells (bMSCs), and from provision of such cells with a matrix permissive of their migration, proliferation, and osteogenic differentiation. That such MSC stimulation could result from treatment with noninvasive (extracorporeal) shock waves (ESWs), and the matrix delivered by injection could enable this therapeutic approac...
2 CitationsSource
#1Su Jing Chan (Agency for Science, Technology and Research)H-Index: 11
#2Elga Esposito (Harvard University)H-Index: 16
Last. Victor Nurcombe (Agency for Science, Technology and Research)H-Index: 47
view all 11 authors...
Background and Purpose: Although VEGF165 (vascular endothelial growth factor-165) is able to enhance both angiogenesis and neurogenesis, it also increases vascular permeability through the blood-br...
3 CitationsSource
#1Ravikumar Rajappa (Brigham and Women's Hospital)H-Index: 1
#2Mark R. Nazal (Harvard University)H-Index: 3
Last. S. D. Martin (Harvard University)H-Index: 4
view all 11 authors...
The purpose of this study was to evaluate the histologic features of the caprine labrum, with emphasis on the chondrolabral junction, with the goal of informing the feasibility of the goat as an animal model. The left hip joint of six adolescent Spanish goats (Capra pyrenaica) was harvested and subjected to anatomical and histological assessments. Human acetabular and femoral head samples, collected during total hip arthroplasty, served as comparison samples. The caprine labrum was found to cons...
1 CitationsSource
#1Abdulmonem Alshihri (Harvard University)H-Index: 8
#2Peer W. Kämmerer (University of Mainz)H-Index: 1
Last. Myron Spector (Brigham and Women's Hospital)H-Index: 67
view all 6 authors...
Abstract Background This study investigated the efficacy of extracorporeal shock wave (ESW) application in stimulating dermal thickness, vascularity, and collagen synthesis of facial skin in a large animal model. Materials and methods The facial skin of the maxillary and mandibular areas of goats (n = 6 per group) was treated with ESWs of different intensities (0.15 and 0.45 mJ/mm2; 1000 pulses). After 4 d, histology and immunohistochemistry were used to evaluate the following: dermal thickness,...
1 CitationsSource
#1Su Jing Chan (Harvard University)H-Index: 11
#2Wanting Niu (VA Boston Healthcare System)H-Index: 3
Last. Eng H. Lo (Harvard University)H-Index: 89
view all 13 authors...
Biomaterials provide novel platforms to deliver stem cell and growth factor therapies for central nervous system (CNS) repair. The majority of these approaches have focused on the promotion of neural progenitor cells and neurogenesis. However, it is now increasingly recognized that glial responses are critical for recovery in the entire neurovascular unit. In this study, we investigated the cellular effects of epidermal growth factor (EGF) containing hydrogels on primary astrocyte cultures. Both...
4 CitationsSource
#1Jeayoung Park (Yale University)H-Index: 2
#2Petr Baranov (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 10
Last. Michael J. Young (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 43
view all 9 authors...
One of the current limitations of retinal transplantation of stem cells as well as other cell types is the dispersion of cells from the injection site (including loss of cells into the vitreous cha...
8 CitationsSource
#1Luiz Felipe Ambra (UNIFESP: Federal University of São Paulo)H-Index: 4
#1Luiz Felipe Ambra (UNIFESP: Federal University of São Paulo)H-Index: 4
Last. Andreas H. Gomoll (Brigham and Women's Hospital)H-Index: 35
view all 6 authors...
Purpose The objective of this study was to evaluate potential cytotoxicity of TXA on articular cartilage by assessing chondrocyte viability of osteochondral explants after exposure to different concentrations and durations of TXA.
14 CitationsSource
#1Jeayoung Park (Yale University)H-Index: 2
#2Petr Baranov (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 10
Last. Michael J. Young (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 43
view all 7 authors...
1 Citations
#1Mehdi RazaviH-Index: 24
Last. Yu Shrike ZhangH-Index: 49
view all 20 authors...