Valérie Fonteyne
Ghent University
CancerInternal medicineRadiologyUrologySurgeryOncologyProspective cohort studyBiochemical recurrenceNocturiaAndrogen deprivation therapyMetastasisProstatectomyProstate cancerBladder cancerLymph nodeToxicityStereotactic body radiotherapyIn patientPost prostatectomyRadiation therapyGeneral surgeryMedicineCohortNODAL
Publications 24
#1Elke Rammant (UGent: Ghent University)H-Index: 6
#2Benedicte Deforche (Vrije Universiteit Brussel)H-Index: 10
Last. Valérie Fonteyne (UGent: Ghent University)H-Index: 5
view all 11 authors...
Introduction Uptake of sufficient physical activity before and after radical cystectomy is important to improve physical and psychosocial outcomes in bladder cancer (BC) patients. Methods In this paper, we describe the development of an evidence-based and theory-informed intervention, guided by the steps of the Intervention Mapping approach, to promote physical activity before and after radical cystectomy in patients with BC. Results The intervention is a home-based physical activity program. Th...
1 CitationsSource
#1Renée Bultijnck (UGent: Ghent University)H-Index: 8
#2Benedicte Deforche (Vrije Universiteit Brussel)H-Index: 60
Last. Piet Ost (UGent: Ghent University)H-Index: 41
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To determine the start exercise prescription dose in metastatic castrate-resistant prostate cancer (mCRPC) patients receiving second-line hormone treatment and recommended phase II exercise prescription. Patients were enrolled in a 3 + 3 dose escalation phase I trial of aerobic, resistance, and flexibility exercises to evaluate dose-limiting tolerance and safety. Tolerance was defined as Borg score ≤ 16 and safety (pain) as a visual analogue scale score (VAS) ≤ 3 and CTCAE grade 3 during resista...
2 CitationsSource
#1Michela Carlotta Massi (Polytechnic University of Milan)H-Index: 2
#2Francesca Gasperoni (Medical Research Council)
Last. Tiziana RancatiH-Index: 27
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Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this project was to analyse a cohort of patients recruited into REQUITE using a deep learning algorithm to identify patient-specific features associated with the development of toxicity, and test the approach by attempting to validate previously published genetic risk factors....
2 CitationsSource
#1Lauren Villeirs (UGent: Ghent University)H-Index: 1
#2Thomas Tailly (UGent: Ghent University)H-Index: 13
Last. Nicolaas Lumen (UGent: Ghent University)H-Index: 29
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The present study assessed the efficacy of hyperbaric oxygen therapy in reducing symptoms of radiation cystitis, a specific type of iatrogenic injury to the bladder, by systematic review of recent literature. The MEDLINE, Embase and Web of Science databases were searched using combinations of the terms "radiation," "cystitis" and "hyperbaric oxygen" to identify articles evaluating patients with radiation cystitis, treated with hyperbaric oxygen therapy. Only recent (
3 CitationsSource
#1Elise De Bleser (Ghent University Hospital)H-Index: 6
#2Ruben Willems (UGent: Ghent University)H-Index: 4
Last. Renée BultijnckH-Index: 8
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The optimal management of patients with oligorecurrent prostate cancer (PCa) is unknown. There is growing interest in metastasis-directed therapy (MDT) for this population. The objective was to assess cost-utility from a Belgian healthcare payer’s perspective of MDT and delayed androgen deprivation therapy (ADT) in comparison with surveillance and delayed ADT, and with immediate ADT. A Markov decision-analytic trial-based model was developed, projecting the results over a 5-year time horizon wit...
2 CitationsSource
#1Petra Seibold (DKFZ: German Cancer Research Center)H-Index: 27
#2A Webb (University of Leicester)H-Index: 9
Last. William Li (The Queen's Medical Center)H-Index: 1
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Abstract Purpose REQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data. Methods An international, prospective cohort study recruited cancer patients in 26 hospitals in eight countries between April 2014 and March 2017. Target recruitment was 5300 patients. Eligible patients had breast, prostate or lung cancer and planned potentially ...
15 CitationsSource
#1Nora Sundahl (Ghent University Hospital)H-Index: 12
#2Gillian Vandekerkhove (UBC: University of British Columbia)H-Index: 11
Last. Piet Ost (Ghent University Hospital)H-Index: 41
view all 17 authors...
Abstract Preclinical data indicate that radiotherapy works synergistically with pembrolizumab, but the effect and toxicity of this combination may depend on radiotherapy timing. We conducted a randomized phase 1 trial combining pembrolizumab with either sequential (A) or concomitant (B) stereotactic body radiotherapy (SBRT) in metastatic urothelial carcinoma (mUC). No dose-limiting toxicity occurred. Treatment-related adverse events (trAEs; Common Terminology Criteria for Adverse Events v4.0) of...
26 CitationsSource
#1Aurélie De Bruycker (UGent: Ghent University)H-Index: 6
#2Elise De Bleser (Ghent University Hospital)H-Index: 6
Last. Piet Ost (UGent: Ghent University)H-Index: 41
view all 10 authors...
Abstract Background Patients with biochemical recurrence following primary prostate cancer (PCa) treatment often experience relapse in the lymph nodes (LNs). Both salvage LN dissection (sLND) and elective nodal radiotherapy (ENRT) are potential treatment options. Objective To describe anatomic patterns of nodal oligorecurrent PCa in relation to different surgical and radiotherapy templates. Design, setting, and participants Patients with biochemical recurrence following primary PCa treatment wer...
24 CitationsSource
#1Valérie Fonteyne (UGent: Ghent University)H-Index: 5
#1Valérie Fonteyne (UGent: Ghent University)H-Index: 5
Last. Karel Decaestecker (Ghent University Hospital)H-Index: 22
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Abstract Introduction There is a gap between optimal and actual use of radiotherapy (RT) in muscle-invasive bladder cancer (MIBC). We investigated the opinions of radiation-oncologists, urologists, and medical oncologists on use of RT in different cases. Barriers and facilitators for applying guidelines were examined. Material and Methods A web-based survey was developed at Ghent University Hospital and conducted from November 18, 2016 to July 17, 2017. The place of primary, adjuvant, and pallia...
4 CitationsSource
#1Nora Sundahl (UGent: Ghent University)H-Index: 12
#2Gillian Vandekerkhove (UBC: University of British Columbia)H-Index: 11
Last. Jo Van Dorpe (Ghent University Hospital)H-Index: 18
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Background: Preclinical data indicates that stereotactic body radiotherapy (SBRT) works synergistically with pembrolizumab, but the effect and potential toxicity might depend on the timing of SBRT. The current study assessed the safety of two different SBRT schedules in combination with pembrolizumab for metastatic urothelial carcinoma (mUC), and explored correlative biomarkers including circulating tumor DNA (ctDNA). Methods: An open-label phase 1 trial was conducted at Ghent University Hospita...