Yiren Yang
Shenyang Pharmaceutical University
TriterpenoidCytotoxicityBiological activityRhizomeGenusAcid hydrolysisEnzymeChemistryGlycosidePhytochemicalIn vitroIn vivoAbsolute configurationPhenylpropanoidLeptopusHeLaAntioxidantXanthocerasEuphorbiaceaeMedicinal plantsOleananeAglyconeAnti-inflammatoryHemolysisAtractylodes lanceaTriterpenoid saponinHydrolysateXanthocerasideDoxorubicin HydrochlorideSaussurea involucrata16-deoxybarringtogenol CCaesalpinia cucullataAnti tumourAnti inflammationCarbohydrate chainsNitric oxideBiochemistryTraditional medicineHuskPharmacology
7Publications
4H-index
35Citations
Publications 7
Newest
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 8 authors...
2 CitationsSource
#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Ting Liu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 10 authors...
Abstract Most of Euphorbiaceae plants are considered as folk medicinal plants because of their various pharmacological effects. However, there are eight Leptopus genus plants which belong to Euphorbiaceae have never be investigated. Thus, four Leptopus genus plants were collected to study their chemical constituents and pharmacological activities. In the present work, the cytotoxicities of the extracts of four Leptopus genus plants were evaluated before phytochemical experiments. And nine new ph...
1 CitationsSource
#1Liping Long (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Lushan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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AbstractSix sesquiterpenoids and four lignans (1–10) were isolated from the n-BuOH extract of the rhizomes of Atractylodes lancea. Among them, the new sesquiterpenoid glycoside named (4 R, 5S, 7R)-hinesolone-11-O-β-ᴅ-glucopyranoside (1), along with three known compounds (2–4) were first obtained from this genus. All the isolates were elucidated by spectroscopic analyses and chemical methods, and the absolute configurations were assigned by electronic circular dichroism spectroscopy technique. In...
5 CitationsSource
#1Shizhou Qi (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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AbstractSaussurea involucrata, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1R, 5R, 6R, 7...
4 CitationsSource
#1Yiren Yang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Liping Long (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Luping Sha (SPU: Shenyang Pharmaceutical University)H-Index: 2
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Barrigenol-like triterpenoids (BATs) showed promising anti-tumor, anti-inflammatory and anti-Alzheimer's activities, while, the inhibitory strength was usually affected by their states with aglycones or glycosides. In order to find more BATs as new anti-tumor agents with much more efficiency, the chemical and pharmaceutical studies were carried out on the acid hydrolysate product (AHP) of Semen Aesculi crude extract. Thirteen BATs, including three new aglycones (1–3), two new glycosides (4, 5) a...
1 CitationsSource
#1Xinxin Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Song Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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Abstract Barrigenol-like triterpenoids (BATs), which contain an unusual oleanane substituted by many hydroxyl groups as the skeleton, are subdivided into five subtypes: barrigenol A 1 , barrigenol A 2 , barrigenol R 1 , barringtogenol C, and 16-deoxybarringtogenol C. The variations in acyl derivatives, hydroxyl groups, and carbohydrate chains in their structures have enhanced the diversity of BATs. Moreover, the stable polyhydroxy-replaced pentacyclic skeleton provides an ideal platform for stru...
19 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Bin Yu (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
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AbstractThe Xanthoceras sorbifolia Bunge husks were known for their abundant triterpenoids resource, which contributed to many bioactivities, such as antitumor, antiinflammatory and neuroprotection. The present study has led to the purification of a new triterpenoid saponin, 21β-O-acetyl-xanthohuskiside A (1), together with six known barrigenol derivatives (2–7), whose structures were authenticated on the basis of NMR, HR-MS, IR spectrum and acid hydrolysis experiment. Compound 7 showed more not...
7 CitationsSource