Alessandro Mangogna
University of Trieste
Complement systemCancerInternal medicinePathologyOncologyClassical complement pathwayTumor necrosis factor alphaChemistryImmunologyImmunohistochemistryTumor microenvironmentLung cancerInflammationHyaluronic acidLungKi-67AdenocarcinomaCancer researchMedicineCell adhesionBiologyImmune systemGastroenterology
51Publications
10H-index
178Citations
Publications 57
Newest
#1Chiara AgostinisH-Index: 21
#2Alessandro MangognaH-Index: 10
Last. Roberta Bulla (UniTS: University of Trieste)H-Index: 27
view all 7 authors...
COVID-19 is characterized by viral-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system via its cross-talk with contact and coagulation systems contributes significantly to the severity and pathological consequences due to SARS-CoV-2 infection. These immunopathological mechanisms overlap in COVID-19 and pre-eclampsia (PE). Thus, mothers contracting SARS-CoV-2 infe...
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#1Chiara AgostinisH-Index: 21
#2Mariagiulia Spazzapan (UniTS: University of Trieste)
Last. Roberta Bulla (UniTS: University of Trieste)H-Index: 27
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The loss of skin integrity has always represented a major challenge for clinicians dealing with dermal defects, such as ulcers (diabetic, vascular and chronic), postoncologic resections (i.e., radical vulvectomy) or dermatologic disorders. The introduction in recent decades of acellular dermal matrices (ADMs) supporting the repair and restoration of skin functionality represented a significant step toward achieving clean wound repair before performing skin grafts. Hard-to-heal ulcers generally d...
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#1Chiara AgostinisH-Index: 21
#2Sonia Zorzet (UniTS: University of Trieste)H-Index: 30
Last. Gaia Morello (University of Palermo)H-Index: 2
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The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic prope...
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#1Paolo Macor (UniTS: University of Trieste)H-Index: 24
#2Paolo DuriguttoH-Index: 19
Last. Francesco TedescoH-Index: 67
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Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on complement involvement at the tissue level. The mechanisms and pathways of local complement activation remain unclear. The aim of this study was to investigate the deposition of complement components in the lungs, kidneys, and liver in patients with COVID-19 patients and to determine the pathway/s of complement activation. We performed immunofluores...
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#1Antonino BelfioreH-Index: 57
#2Giovanni CentonzeH-Index: 12
Last. Massimo MilioneH-Index: 33
view all 9 authors...
Background: On December 2019, an outbreak of atypical pneumonia, known as COVID-19, was identified in Wuhan, China. This disease, characterized by the rapid human-to-human transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly in more than 200 countries. Northern Italy’s regions have been hit hard in terms of deaths. Here, we report the experience of the Pathology Department of the Fondazione IRCCS Istituto Nazionale Tumori (INT) in Milan, the first ...
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#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Patrick Maisonneuve (IEO: European Institute of Oncology)H-Index: 136
Last. Stefano Di DomenicoH-Index: 10
view all 15 authors...
Updates in classification of gastro-entero-pancreatic neuroendocrine neoplasms better reflect the biological characteristics of these tumours. In the present study, we analysed the characteristics of neuroendocrine tumours that could aid in a more precise stratification of risk groups. In addition, we have highlighted the importance of grade (re)assessment based on investigation of secondary tumour lesions. Two hundred and sixty-four cases of neuroendocrine tumours of gastro-entero-pancreatic or...
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#2Alessandro Mangogna (UniTS: University of Trieste)H-Index: 10
Last. Luca Reggiani BonettiH-Index: 20
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Abstract null null Background null Poorly differentiated clusters (PDCs) have gained a significant prognostic role in colorectal carcinomas (CRCs) being associated to high risk of lymph node metastasis, shorter survival time and poor prognosis. The knowledge in PDC biology is not completely clear. null null null Materials and methods null We assessed Ki-67 LI in 45 CRCs showing ≥10 PDCs. We distinguished PDCs at the periphery of the tumor masses (pPDCs) from those within the tumor masses (cPDCs)...
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#5Walter Arancio (AG: Analysis Group)H-Index: 1
Due to the high expression of P-selectin glycoprotein ligand-1 (PSGL-1) in lymphoproliferative disorders and in multiple myeloma, it has been considered as a potential target for humoral immunotherapy, as well as an immune checkpoint inhibitor in T-cells. By investigating the expression of SELPLG in 678 T- and B-cell samples by gene expression profiling (GEP), further supported by tissue microarray and immunohistochemical analysis, we identified anaplastic large T-cell lymphoma (ALCL) as constit...
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#1Paola Zacchi (UniTS: University of Trieste)H-Index: 16
#2Beatrice Belmonte (University of Palermo)H-Index: 11
Last. Violetta Borelli (UniTS: University of Trieste)H-Index: 12
view all 7 authors...
Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to cellular iron homeostasis by favouring its export. Down-regulation of HEPH expression, possibly by stimulating cell proliferation due to an increase in iron availability, has shown to correlate with poor survival in breast cancer. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tension present, however, HEPH distribution in lung cancer and its influence on prognosis ...
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#1Massimo MilioneH-Index: 33
#2Patrick MaisonneuveH-Index: 136
Last. Carlo CapellaH-Index: 86
view all 27 authors...
BACKGROUND: Little information is available concerning prognostic factors of bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical and molecular approach could be used for their prognostic evaluation. METHODS: Morphological (including combined features), proliferative (mitotic count/Ki-67 index), immunohistochemical (napsin A, p-40, TTF-1, CD44, OTP, SSTR...
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