Zhibo Guan
Shenyang Pharmaceutical University
Blood lipidsMass spectrometryFourier transform ion cyclotron resonanceCarbohydrate metabolismChemistryDecoctionMetabolic pathwayRadixMetabolomicsFormic acidCholesterolHyperlipidemiaGinsengMitomycin CContext (language use)NiacinTriterpeneSpleenChromatographyMicronucleus testLipid metabolismAmino acidPharmacology
Publications 3
#1Yi CaiH-Index: 2
#2Min ZhaoH-Index: 8
Last. Chunjie ZhaoH-Index: 6
view all 6 authors...
: Semen descurainiae oil (SDO) is an important traditional Chinese medicine that was recently discovered to have the function of reducing blood lipids. Metabolomics analyses of plasma, liver and kidney in rats were performed using 1 H-NMR and LC-MS to illuminate the lower blood lipid concentration effect of SDO, and niacin was considered as the active control. The measure of total cholesterol (TC) and low-density-lipoprotein cholesterol (LDL-C) in plasma showed that SDO treatment decreased signi...
1 CitationsSource
#1Zhibo Guan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Abstract Sijunzi decoction, a renowned Chinese prescription has long been utilized to treat gastrointestinal problems. In the context of this research work, the use of Ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry was made to separate and characterize the components of Sijunzi decoction. The performance of Liquid chromatography was carried out on a C8 column (150 mm × 2.1 mm, 1.8 μm); moreover, the mobile phase were consist...
10 CitationsSource
#1Zhibo Guan (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Juan Wu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Abstract Ethnopharmacological relevance Sijunzi decoction (SJZD) is a well known traditional Chinese prescription used for the treatment of gastrointestinal disorders and immunity enhancement. It has been found to indeed improve life quality of chemotherapy patients and extensive used in clinical conbined with chemotherapeutics for the treatment of cancer. Aim of the study The aim of this study was to investigate the preventive effect of the immunotoxicity of SJZD on mitomycin C (MMC) and the me...
13 CitationsSource