Paolo Zunino
Polytechnic University of Milan
Porous mediumBiot numberPhysicsMathematical optimizationMicrocirculationMathematical analysisFinite element methodBiomedical engineeringPoromechanicsMaterials scienceApplied mathematicsDrug releaseMathematicsFlow (mathematics)Computer scienceComputer simulationMechanicsMedicineDiscretizationPartial differential equation
151Publications
28H-index
1,970Citations
Publications 148
Newest
#1Luca PossentiH-Index: 4
Last. Maria Laura CostantinoH-Index: 14
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#1Alberto GuadagniniH-Index: 40
#2L. GuadagniniH-Index: 2
Last. Paolo Ruffo (Eni)H-Index: 7
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#1Davide Carlo Ambrosi (Polytechnic University of Milan)H-Index: 31
#2Pasquale Ciarletta (Polytechnic University of Milan)H-Index: 26
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
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Nanomedicine is the emerging medical research branch which employs nanotechnological devices to improve clinical diagnosis and to design more effective therapeutic methodologies. In particular, functionalized nanoparticles have proved their clinical usefulness for cancer therapy, either as vectors for targeted drug delivery or for hyperthermia treatment. The effectiveness of such novel therapeutic strategies in nanomedicine exploits the capability of the nanoparticles to penetrate into the livin...
Source
#1Bianca Giovanardi (Polytechnic University of Milan)H-Index: 4
#2Luca Formaggia (Polytechnic University of Milan)H-Index: 32
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
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We propose a mathematical model and a discretization strategy for the simulation of pressurized fractures in porous media accounting for the poroelastic effects due to the interaction of pressure and flow with rock deformations. The aim of the work is to develop a numerical scheme suitable to model the interplay among several fractures subject to fluid injection in different geometric configurations, in view of the application of this technique to hydraulic fracturing. The eXtended Finite Elemen...
8 CitationsSource
#1Luca PossentiH-Index: 4
Last. Paolo ZuninoH-Index: 28
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#1Luca PossentiH-Index: 4
Last. Paolo ZuninoH-Index: 28
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#1Martina Bukac (ND: University of Notre Dame)H-Index: 11
#2Ivan Yotov (University of Pittsburgh)H-Index: 33
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
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We study the interaction between a poroelastic medium and a fracture filled with fluid. The flow in the fracture is described by the Brinkman equations for an incompressible fluid and the poroelastic medium by the quasi-static Biot model. The two models are fully coupled via the kinematic and dynamic conditions. The Brinkman equations are then averaged over the cross-sections, giving rise to a reduced flow model on the fracture midline. We derive suitable interface and closure conditions between...
17 CitationsSource
#1Laura Iannetti (Polytechnic University of Milan)H-Index: 1
#2Giovanna D'Urso (Polytechnic University of Milan)H-Index: 1
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
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Next generation bioreactors are being developed to generate multiple human cell-based tissue analogs within the same fluidic system, to better recapitulate the complexity and interconnection of human physiology [1, 2]. The effective development of these devices requires a solid understanding of their interconnected fluidics, to predict the transport of nutrients and waste through the constructs and improve the design accordingly. In this work, we focus on a specific model of bioreactor, with mul...
11 CitationsSource
#1Mahdi Nabil (PSU: Pennsylvania State University)H-Index: 6
#2Paolo Zunino (Polytechnic University of Milan)H-Index: 28
The application of hyperthermia to cancer treatment is studied using a novel model arising from the fundamental principles of flow, mass and heat transport in biological tissues. The model is defined at the scale of the tumour microenvironment and an advanced computational scheme called the embedded multiscale method is adopted to solve the governing equations. More precisely, this approach involves modelling capillaries as one-dimensional channels carrying flow, and special mathematical operato...
29 CitationsSource