Paolo Zunino

Polytechnic University of Milan

Porous mediumBiot numberPhysicsMathematical optimizationMicrocirculationMathematical analysisFinite element methodBiomedical engineeringPoromechanicsMaterials scienceApplied mathematicsDrug releaseMathematicsFlow (mathematics)Computer scienceComputer simulationMechanicsMedicineDiscretizationPartial differential equation

151Publications

28H-index

1,970Citations

Publications 148

A computational model for microcirculation including Fahraeus-Lindqvist effect, plasma skimming and fluid exchange with the tissue interstitium.

#1Luca Possenti (Polytechnic University of Milan)H-Index: 4

#2Simone Di Gregorio (Polytechnic University of Milan)H-Index: 3

Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28

view all 7 authors...

: We present a two-phase model for microcirculation that describes the interaction of plasma with red blood cells. The model takes into account of typical effects characterizing the microcirculation, such as the Fahraeus-Lindqvist effect and plasma skimming. Besides these features, the model describes the interaction of capillaries with the surrounding tissue. More precisely, the model accounts for the interaction of capillary transmural flow with the surrounding interstitial pressure. Furthermo...

#1Rana Zakerzadeh (University of Texas at Austin)H-Index: 6

#2Paolo Zunino (Polytechnic University of Milan)H-Index: 28

We study the effect of poroelasticity on fluid–structure interaction. More precisely, we analyze the role of fluid flow through a deformable porous matrix in the energy dissipation behavior of a poroelastic structure. For this purpose, we develop and use a nonlinear poroelastic computational model and apply it to the fluid–structure interaction simulations. We discretize the problem by means of the finite element method for the spatial approximation and using finite differences in time. The nume...

#1Daniele CerroniH-Index: 3

#2Florin Adrian RaduH-Index: 24

Last. Paolo ZuninoH-Index: 28

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#1Luca PossentiH-Index: 4

#2Giustina CasagrandeH-Index: 7

Last. Paolo ZuninoH-Index: 28

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#1Federica LaurinoH-Index: 2

Last. Paolo ZuninoH-Index: 28

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A mixed finite element method for modeling the fluid exchange between microcirculation and tissue interstitium

#1Daniele Cerroni (Polytechnic University of Milan)H-Index: 3

#2Federica Laurino (Polytechnic University of Milan)H-Index: 2

Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28

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Thanks to dimensional (or topological) model reduction techniques, small inclusions in a three-dimensional (3D) continuum can be described as one-dimensional (1D) concentrated sources, in order to reduce the computational cost of simulations. However, concentrated sources lead to singular solutions that still require computationally expensive graded meshes to guarantee accurate approximation. The main computational barrier consists in the ill-posedness of restriction operators (such as the trace...

Correction to: Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis.

#1Derek A. NicholsH-Index: 1

#1Derek A. NicholsH-Index: 1

Last. Riccardo Gottardi (University of Pittsburgh)H-Index: 17

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Mathematical modelling, analysis and numerical approximation of second order elliptic problems with inclusions

#1Tobias Köppl (University of Stuttgart)H-Index: 8

#2Ettore Vidotto (TUM: Technische Universität München)H-Index: 4

Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28

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Many biological and geological systems can be modeled as porous media with small inclusions. Vascularized tissue, roots embedded in soil or fractured rocks are examples of such systems. In these ap...

#1Ilona Ambartsumyan (University of Pittsburgh)H-Index: 6

#2Eldar Khattatov (University of Pittsburgh)H-Index: 5

Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28

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We study a finite element computational model for solving the coupled problem arising in the interaction between a free fluid and a fluid in a poroelastic medium. The free fluid is governed by the Stokes equations, while the flow in the poroelastic medium is modeled using the Biot poroelasticity system. Equilibrium and kinematic conditions are imposed on the interface. A mixed Darcy formulation is employed, resulting in continuity of flux condition of essential type. A Lagrange multiplier method...

Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis

#1Derek A. NicholsH-Index: 1

#1Derek A. NicholsH-Index: 1

Last. Riccardo Gottardi (University of Pittsburgh)H-Index: 17

view all 5 authors...

Bioreactors are systems that can be used to monitor the response of tissues and cells to candidate drugs. Building on the experience developed in the creation of an osteochondral bioreactor, we have designed a new 3D printed system, which allows optical access to the cells throughout testing for in line monitoring. Because of the use of 3D printing, the fluidics could be developed in the third dimension, thus maintaining the footprint of a single well of a typical 96 well plate. This new design ...

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