Manil Subesinghe
St Thomas' Hospital
Internal medicineRadiologyPET-CTSurgeryMagnetic resonance imagingOncologyMedical physicsPositron emission tomographyBiopsyHead and neck squamous-cell carcinomaCarcinomaMalignancyContext (language use)Prostate cancerPositron Emission Tomography-Computed TomographyNuclear medicineFdg pet ctRadiation therapyClinical trialComputed tomographyMedicine
Publications 37
#2Georgios Krokos (St Thomas' Hospital)
Last. Barbara M. Fischer (St Thomas' Hospital)H-Index: 23
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Lung cancer is the leading cause of cancer related death around the world although early diagnosis remains vital to enabling access to curative treatment options. This article briefly describes the current role of imaging, in particular 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET/CT, in lung cancer and specifically the role of artificial intelligence with CT followed by a detailed review of the published studies applying artificial intelligence (ie, machine learning and deep learning), on FDG PET ...
#1K. Fatania (Leeds Teaching Hospitals NHS Trust)
#2P.J. Brown (Leeds Teaching Hospitals NHS Trust)H-Index: 2
Last. Andrew Scarsbrook (University of Leeds)H-Index: 29
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AIM To compare the interobserver reliability and diagnostic accuracy of the British Thoracic Society (BTS) scale and other visual assessment criteria in the context of 2-[18F]-fluoro-2-deoxy- d- glucose (FDG) positron-emission tomography (PET)-computed tomography (CT) evaluation of solid pulmonary nodules (SPNs). MATERIALS AND METHODS Fifty patients who underwent FDG PET-CT for assessment of a SPN were identified. Seven reporters with varied experience at four centres graded FDG uptake visually ...
#1Manil Subesinghe ('KCL': King's College London)H-Index: 12
#2Meghana Kulkarni ('KCL': King's College London)H-Index: 2
Last. Gary Cook ('KCL': King's College London)H-Index: 62
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Prostate cancer is the commonest malignancy to affect men in the United Kingdom. Extraprostatic disease detection at staging and in the setting of biochemical recurrence is essential in determining treatment strategy. Conventional imaging including computed tomography and bone scintigraphy are limited in their ability to detect sites of loco-regional nodal and metastatic bone disease, particularly at clinically relevant low prostate-specific antigen levels. The use of positron emission tomograph...
#1Stephen Liddy (UCD: University College Dublin)H-Index: 1
#2Andrew Mallia (Mater Dei Hospital)H-Index: 1
Last. David Murphy (UCD: University College Dublin)H-Index: 5
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Since its introduction into clinical practice, 2-deoxy-2-[18F]flu-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) has become firmly established in the field of oncological...
#1Yik Long Man (St Thomas' Hospital)
#2Manil Subesinghe (St Thomas' Hospital)H-Index: 12
Last. Sujith Subesinghe (St Thomas' Hospital)
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#1D.j. Murphy ('KCL': King's College London)H-Index: 2
#2L. Royle (Guy's and St Thomas' NHS Foundation Trust)H-Index: 1
Last. Manil Subesinghe ('KCL': King's College London)H-Index: 12
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Abstract Purpose British Thoracic Society (BTS) guidelines advocate using FDG PET-CT with the Herder model to estimate malignancy risk in solitary pulmonary nodules (SPNs). Qualitative and semi-quantitative assessment of SPN uptake is based upon analysis of Ordered Subset Expected Maximisation (OSEM) PET images. Our aim was to assess the effect of a Bayesian Penalised Likelihood (BPL) PET reconstruction on the assessment of SPN FDG uptake and estimation of malignancy risk (Herder score). Methods...
3 CitationsSource
#1Faye Sharpley (University of Oxford)H-Index: 9
#1Faye A. Sharpley (University of Oxford)H-Index: 3
Last. Karthik Ramasamy (University of Oxford)H-Index: 17
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Background The risk of recurrence of solitary plasmacytoma (SP)/progression to MM is well established, but patient, imaging and treatment factors influencing risk of progression require further evaluation. Methods This is a retrospective analysis of 66 SP patients (23 UK, 43 Brazil) diagnosed 1989–2016. Patient baseline characteristics were recorded. The incidence of progression to MM was calculated, including biochemical and imaging findings and the treatment modality received. Survival estimat...
3 CitationsSource
#1Jacqueline Dinnes (University of Birmingham)H-Index: 26
#2Lavinia Ferrante di Ruffano (University of Birmingham)H-Index: 12
Last. Hywel C. Williams (University of Nottingham)H-Index: 111
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Background Melanoma is one of the most aggressive forms of skin cancer, with the potential to metastasise to other parts of the body via the lymphatic system and the bloodstream. Melanoma accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Various imaging tests can be used with the aim of detecting metastatic spread of disease following a primary diagnosis of melanoma (primary staging) or on clinical suspicion of disease recurrence (re-...
10 CitationsSource
#1Asim AfaqH-Index: 14
#2Fergus V. GleesonH-Index: 58
Last. Jamshed Bomanji (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 12
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The purpose of these guidelines is to assist specialists in Nuclear Medicine and Radionuclide Radiology in recommending, performing, interpreting and reporting 18F-fluciclovine PET/computed tomography. It should be recognised that adherence to the guidance in this document will not assure an accurat
2 CitationsSource