Liping Zhou
Hong Kong Polytechnic University
EndocrinologyBone remodelingChemistryIn vitroIn vivoOxidative stressSalvia miltiorrhizaOsteoporosisEstrogenDrugIcariinDoxorubicinG-Protein Coupled Estrogen Receptor 1Saturated fatSignal transductionMedicineOvariectomized ratEstrogen receptorProtein kinase APharmacology
16Publications
5H-index
94Citations
Publications 15
Newest
#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 7 authors...
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#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Ka-Ying Wong (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 8 authors...
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#1Xiao-Li Dong (PolyU: Hong Kong Polytechnic University)H-Index: 11
#2Wen Xuan Yu (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 5 authors...
Oxidative stress (OS) is the common mechanism for age-related diseases. The co-occurrence of osteoporosis (OP) and cardiovascular disease (CVD) in postmenopausal women makes it warranted to find a holistic approach for treatment of multiple diseases or conditions. The rhizome of Ligusticum chuanxiong Hort. (CX), which has high anti-oxidant properties and is widely used for CVD treatment in China, might be the potential candidate. In the present study, CX ethanol extract (CXE) was applied to H2O2...
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#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Christina Chui-Wa Poon (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 9 authors...
Icariin, a flavonoid phytoestrogen derived from Herba epimedii, has been reported to exert estrogenic effects in bone and activate phosphorylation of estrogen receptor (ER) alpha in osteoblastic cells. However, it is unclear whether icariin selectively exerts estrogenic activities in bone without inducing undesirable effects in other estrogen-sensitive tissues. The present study aimed to investigate the tissue-selective estrogenic activities of icariin in estrogen-sensitive tissues in vivo and i...
2 CitationsSource
#1Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
#2Chui Wa Christina Poon (PolyU: Hong Kong Polytechnic University)
Last. Hui-Hui Xiao (PolyU: Hong Kong Polytechnic University)H-Index: 4
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Demands for natural products, in the form of botanicals, dietary supplements, and herbal medicine, for management of chronic diseases are increasing globally. Natural products might be an alternative for the management of bone health to meet the demands of a growing aging population. Different types of natural products, including Chinese herbal medicine decoctions, herbs, and isolated phytochemicals, have been demonstrated to exert bone protective effects. The most common types of bone protectiv...
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#1Quan Gui Gao (PolyU: Hong Kong Polytechnic University)H-Index: 6
#2Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 6 authors...
Abstract Background Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway. Our study aimed to delineate the mechanisms by which Rg1 activates the rapid ER signaling pathways. Methods ER-positive human breast cancer MCF-7 cells and ER-negative human embryonic kidney HEK293 cells were treated with Rg1 (10−12M, 10−8M), 17s-estradiol (10−8M), or vehicle. Immunoprecipitation was conducted to investigate the int...
1 CitationsSource
#1Heting Hou (PolyU: Hong Kong Polytechnic University)H-Index: 1
#2Dong Zhang (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Yi Wang (PolyU: Hong Kong Polytechnic University)H-Index: 16
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Conventional chemotherapy, because of the high dose to keep the drug above the minimum effective concentration, possesses severe side effects and brings extra pain to patients. A controlled release drug delivery system, which is a bilayer self-assembled nanoparticle (NP) in this study, can solve this problem. Zein, a biodegradable natural protein from corn, was selected for the first layer of the drug encapsulation. The second layer was formed via the reversible ionic hydrogen bonds between zein...
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#1Sisi Cao (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Xue-Lian Tian (PolyU: Hong Kong Polytechnic University)H-Index: 1
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
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Oleanolic acid (OA) and ursolic acid (UA) are the major chemical constituents in Fructus Ligustri Lucidi (FLL), a kidney-tonifying Chinese herb that is previously shown to improve bone properties and enhance calcium balance in aged female rats. The present study was designed to study if OA and UA act as the active ingredients in FLL to exert the positive effects on bone and mineral metabolism in aged rats. Aged (13-month-old) Sprague Dawley female rats were randomly assigned to four groups with ...
5 CitationsSource
#1Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
#2Ka-Ying Wong (PolyU: Hong Kong Polytechnic University)H-Index: 2
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 35
view all 8 authors...
Danggui Buxue Tang (DBT), a traditional Chinese Medicine decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), is commonly prescribed for women in China as a remedy for menopausal symptoms. Previous study indicated that DBT stimulated cell growth and differentiation of human osteosarcoma MG-63 cells and exhibited estrogenic properties via estrogen receptors (ERs). The present study aimed to study the bone protective effects of DBT and its potential interactions with Selec...
8 CitationsSource
#1Yan Zhang (SHU: Shanghai University)H-Index: 26
#2Liping Zhou (PolyU: Hong Kong Polytechnic University)H-Index: 5
Last. Man Sau WongH-Index: 35
view all 11 authors...
// Yan Zhang 1, 2, 3 , Li-Ping Zhou 4 , Xiao-Li Li 5 , Yong-Jian Zhao 1, 3 , Ming-Xian Ho 4 , Zuo-Cheng Qiu 6 , Dong-Feng Zhao 1, 3 , Daniel Kam-Wah Mok 4 , Qi Shi 1, 3 , Yong-Jun Wang 1, 3, 7 and Man-Sau Wong 2, 4 1 Spine Research Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PRC 2 State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, PRC 3 Key La...
5 CitationsSource
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