Gang Wei
Guangzhou University
NeuriteEndocrinologymicroRNAHippocampal formationCREBRegulation of gene expressionPresenilinGene expression profilingAutophagyLong-term potentiationNeuroprotectionSynaptophysinOncogeneHippocampusCa2+/calmodulin-dependent protein kinaseAlzheimer's diseaseStrokeSignal transductionMicroarray analysis techniquesBiology
4Publications
3H-index
86Citations
Publications 4
Newest
#1Yuqing Liu (GU: Guangzhou University)H-Index: 2
#1Yuqing Liu (GU: Guangzhou University)H-Index: 1
Last. Dong-Feng Chen (GU: Guangzhou University)H-Index: 6
view all 10 authors...
: Ischemic strokes carry a significant risk of mortality and recurrent vascular events. Recent studies suggest that changes in microRNAs (miRNAs or miRs) may affect the development of the stroke. However, few studies have investigated the role of miRNAs in behavioral disorder in early stroke. In the present study, animal models of middle cerebral artery occlusion (MCAO) are used, as well as a cell model of neurite outgrowth to further investigate the role of miRNAs in targeting synapse-associate...
3 CitationsSource
#1Fei Li (GU: Guangzhou University)H-Index: 6
#1Fei Li (GU: Guangzhou University)H-Index: 1
Last. Dong-Feng Chen (GU: Guangzhou University)H-Index: 6
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Abstract Alzheimer׳s disease (AD) is the most common form of dementia in the elderly. The recent evidence in AD research suggests that alterations in the microRNA (miRNA) could contribute to risk for the disease. However, little is understood about the roles of miRNAs in cognitive impairment of early Alzheimer׳s disease (AD). Here, we used 5-month-old APP/PS1 mice, which mimic many of the salient features of the early stage of AD pathological process, to further investigate the roles of miRNAs i...
19 CitationsSource
#1Yunbo Chen (GU: Guangzhou University)H-Index: 3
#2Gang Wei (GU: Guangzhou University)H-Index: 3
Last. Dong-Feng Chen (GU: Guangzhou University)H-Index: 6
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Abstract β-Asarone is an active component of the Acori graminei rhizome that is a traditional Chinese medicine clinically used in treating dementia in China. However, the cognitive effect of β-asarone and its mechanism has remained elusive. Here, we used asenescence-accelerated prone 8 (SAMP8) mice, which mimic many of the salient features of Alzheimer׳s disease (AD), to further investigate whether modulation of the ROCK signaling pathway and/or autophagy, synaptic loss is involved in the effect...
24 CitationsSource
#1Gang Wei (GU: Guangzhou University)H-Index: 3
#2Yunbo Chen (GU: Guangzhou University)H-Index: 3
Last. Hui Nie (GU: Guangzhou University)H-Index: 2
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Abstract β-Asarone, an active component of the Acori graminei rhizome that has been used as traditional Chinese herb, has been reported to be capable of inhibiting neuronal apoptosis. However, the signaling mechanism underlying the inhibitory effect of β-asarone has remained elusive. This study was aimed to investigate whether the CaMKII signaling pathway is involved in the β-asarone mediated neuroprotection. Using PC12 cells and primary cultures of cortical neurons treated with amyloid-β (Aβ)(1...
38 CitationsSource